DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and PRSS21

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	NP_006790.1	Gene:	PRSS21 / 10942	HGNCID:	9485	Length:	314	Species:	Homo sapiens

Alignment Length:	307	Identity:	99/307 - (32%)
Similarity:	144/307 - (46%)	Gaps:	64/307 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 PAKRECAECS--CGNINTRHRIVGGQETEVHEYPWMIMLMWFGNFYCGASLVNDQYALTAAHC-- 124
            |..:|.|..|  ||......|||||::.|:..:||...|..:.:..||.||::.::|||||||
Human    21 PESQEAAPLSGPCGRRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFE 85

  Fly   125 --------------------------VNGFYHRLITVRLLEHNRQDSHVKIVDRRVSRVLIHPKY 163
                                      :..:|.|..                    ||.:.:.|:|
Human    86 TYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYF--------------------VSNIYLSPRY 130

  Fly   164 STRNFDSDIALIRFNEPVRLGIDMHPVCMPTPSENYAGQT-AVVTGWGALSEGG--PISDTLQEV 225
             ..|...||||::.:.||.....:.|:|:...:..:..:| ..|||||.:.|..  |...|||||
Human   131 -LGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEV 194

  Fly   226 EVPILSQEECRN--SNYGESK-ITDNMICAGYVEQGGKDSCQGDSGGPMHVLGSGDAYQLAGIVS 287
            :|.|::...|.:  ..|...| |..:|:|||.. |||||:|.||||||:....:|..||: |:||
Human   195 QVAIINNSMCNHLFLKYSFRKDIFGDMVCAGNA-QGGKDACFGDSGGPLACNKNGLWYQI-GVVS 257

  Fly   288 WGEGCAKPNAPGVYTRVGSFNDWIAENTRDACSCAQPEAAGEPASPM 334
            ||.||.:||.|||||.:....:|| :........:||    :|:.|:
Human   258 WGVGCGRPNRPGVYTNISHHFEWI-QKLMAQSGMSQP----DPSWPL 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	87/262 (33%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	88/264 (33%)
PRSS21	NP_006790.1	Tryp_SPc	42..283	CDD:238113	88/264 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100031
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810