DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18735 and corin

DIOPT Version :9

Sequence 1:	NP_652645.1	Gene:	CG18735 / 59137	FlyBaseID:	FBgn0042098	Length:	364	Species:	Drosophila melanogaster
Sequence 2:	XP_009295418.2	Gene:	corin / 100320926	ZFINID:	ZDB-GENE-060224-3	Length:	1036	Species:	Danio rerio

Alignment Length:	324	Identity:	95/324 - (29%)
Similarity:	145/324 - (44%)	Gaps:	43/324 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LACATPSLRSASDPEKILNNLAQLRQSSFL----DW-------IQSILGPEVPAEWSSPAKR--- 67
            :.|....|.|....:.:|:....:|:..:|    ||       :|.:|  |...:.....|:
Zfish   715 VTCTQMGLGSPLSTDAMLDVSPVVRRKRWLHVDPDWSPENMLPLQGLL--EKRGQSCQSYKKISL 777

  Fly    68 ECAECSCGN---INTRHRIVGGQETEVHEYPWMIMLMWF-GNFYCGASLVNDQYALTAAHCVNG- 127
            :|....||.   .....||:||:.:....:||...|... ....||..|:.:::|||.|||..|
Zfish   778 QCTRDECGRRPAARLVKRILGGRTSRPGRWPWQCSLQSDPSGHICGCVLIGNKWALTVAHCFEGR 842

  Fly   128 ----FYHRLITVRLLEHNRQDSHVKIVDRRVSRVLIHPKYSTRNFDSDIALIRFNEPVRLGIDMH 188
                .:..::.:..|:|    ....:..|||..:::|.:|:....|.||:::.....|.:...:.
Zfish   843 ESADVWKVVLGINNLDH----PSPYMQTRRVKSIIVHSRYNRAVVDYDISVLELESEVLVTSYVR 903

  Fly   189 PVCMP-----TPSENYAGQTAVVTGWGALSEGGPISDTLQEVEVPILSQEECRNSNYGESKITDN 248
            |||:|     ...:.|..    :||||.:....|..  |||.||.|:|..:|: |.:....||..
Zfish   904 PVCLPRHGQLPKPDKYCH----ITGWGHVGNRMPFK--LQEGEVRIISVSQCQ-SYFDMKTITSR 961

  Fly   249 MICAGYVEQGGKDSCQGDSGGPMHVLGSGDAYQLAGIVSWGEGC-AKPNAPGVYTRVGSFNDWI 311
            |:|||| |.|..|||.||||||:........:.|.|:.|||..| :|...||||..|..|.:||
Zfish   962 MLCAGY-EAGTIDSCMGDSGGPLVCEEDDGHWSLYGLTSWGSVCFSKVLGPGVYANVTHFTEWI 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18735	NP_652645.1	Tryp_SPc	82..311	CDD:214473	78/240 (33%)
CG18735	NP_652645.1	Tryp_SPc	83..314	CDD:238113	79/241 (33%)
corin	XP_009295418.2	CRD_corin_1	136..258	CDD:143554
		LDLa	268..299	CDD:238060
		LDLa	301..335	CDD:238060
		Ldl_recept_a	342..372	CDD:278486
		LDLa	382..409	CDD:238060
		CRD_corin_2	448..569	CDD:143579
		LDLa	574..608	CDD:238060
		LDLa	<620..646	CDD:238060
		LDLa	649..683	CDD:238060
		SR	689..>728	CDD:214555	3/12 (25%)
		Tryp_SPc	796..1027	CDD:238113	79/241 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910