DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RAP1B and Rala

DIOPT Version :9

Sequence 1:	NP_001010942.1	Gene:	RAP1B / 5908	HGNCID:	9857	Length:	184	Species:	Homo sapiens
Sequence 2:	NP_525063.1	Gene:	Rala / 31332	FlyBaseID:	FBgn0015286	Length:	201	Species:	Drosophila melanogaster

Alignment Length:	191	Identity:	90/191 - (47%)
Similarity:	135/191 - (70%)	Gaps:	11/191 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     4 YKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDAQQCMLEILDTAGTEQFTAMR 68
            :|::::|||||||||||:||:...|||.|:||..|||||:|.:|.::..::||||||.|.:.|:|
  Fly    12 HKVIMVGSGGVGKSALTLQFMYDEFVEDYEPTKADSYRKKVVLDGEEVQIDILDTAGQEDYAAIR 76

Human    69 DLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTDDVPMILVGNKCDLEDERVVGKEQGQN 133
            |.|.::|:||..|:|||...:|...|:.||||||||:.:.:|.:||||||||.|:|.|...:.|.
  Fly    77 DNYFRSGEGFLCVFSITDDESFQATQEFREQILRVKNDESIPFLLVGNKCDLNDKRKVPLSECQL 141

Human   134 LARQWNNCAFLESSAKSKINVNEIFYDLVRQI-NRKT----PVPGKA-----RKKSSCQLL 184
            .|:|| ...::|:|||::.||:::|:||:|:| :|||    ...|:|     :::..|.||
  Fly   142 RAQQW-AVPYVETSAKTRENVDKVFFDLMREIRSRKTEDSKATSGRAKDRCKKRRLKCTLL 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAP1B	NP_001010942.1	Rap1	3..167	CDD:133375	82/163 (50%)
		Interaction with KRIT1. /evidence=ECO:0000269\|PubMed:22577140	25..67		20/41 (49%)
		Effector region. /evidence=ECO:0000305	32..40		4/7 (57%)
Rala	NP_525063.1	RalA_RalB	12..174	CDD:206710	82/162 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810