DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Zfp24 and CG31441

DIOPT Version :9

Sequence 1:	NP_001344376.1	Gene:	Zfp24 / 59057	MGIID:	1929704	Length:	368	Species:	Mus musculus
Sequence 2:	NP_731558.1	Gene:	CG31441 / 326139	FlyBaseID:	FBgn0051441	Length:	341	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	77/365 - (21%)
Similarity:	124/365 - (33%)	Gaps:	129/365 - (35%)

- Green bases have known domain annotations that are detailed below.

Mouse     6 VEEDSILIIPNPDEE---------EKILRVKLEEDPDGEEGSSISWNHLPDPEVFRQRFRQFGYQ 61
            |:.|.||...|...|         .|:||.|...|.:.::         ||.|..:|
  Fly    61 VQLDRILTFRNKCLEVHKSFMAANRKLLRKKAIVDEELDK---------PDVEKLQQ-------- 108

Mouse    62 DSPGPREAVSQLRELCRLWLRPETHTKEQILELVVLEQFVAILPKELQTWVREHHPENGEEAVAV 126
                            .||    .||.:::  .|.:.....:|        ||.|.:| |:|
  Fly   109 ----------------DLW----DHTDQEM--CVAMADTAGLL--------REDHNDN-EKA--- 139

Mouse   127 LEDLESELDDPGQPVSLRRQKREVLVEEITSQEDAQGLPSSELDAVENQLKWASWELHSLRHCDD 191
                                            :||:....:|    :||.:....:...:.||.:
  Fly   140 --------------------------------KDAEDATQNE----KNQEEQVQVQTEEVEHCQE 168

Mouse   192 DATTENGALAPKQEMASAGESHEGPGTLNIGVPQLFKYGETCFPKGRFERKRNPSRKKQHICDEC 256
            .        .....:.|.|.|...|                         ||.....|...||:|
  Fly   169 Q--------LHNMSIISKGVSARVP-------------------------KRTKRNSKSWFCDQC 200

Mouse   257 GKHFSQGSALILHQRIHSGEKPYGCVECGKAFSRSSILVQHQRVHTGEKPYKCLECGKAFSQNSG 321
            |..|...:.|.||.:.|||.||:.|..|...:...:.:.:|:.:||..:||.|..|.|.:...|.
  Fly   201 GGVFKSSTYLKLHLQRHSGHKPFACDICQAKYYTDNEMRRHRILHTDARPYACRFCSKTYRGCSS 265

Mouse   322 LINHQRIHTGEKPYECVQCGKSYSQSSNLFRHQRRHNAEK 361
            .:.|:|.||.|:|::|..|.|:::.:|...:|:..|..::
  Fly   266 KVVHERTHTNERPFQCQHCDKAFTSTSTRQKHEMLHTNQR 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Zfp24	NP_001344376.1	SCAN	48..159	CDD:128708	14/110 (13%)
		COG5048	<249..329	CDD:227381	27/79 (34%)
		Necessary and sufficient for nuclear localization. /evidence=ECO:0000250	251..301		16/49 (33%)
		C2H2 Zn finger	253..273	CDD:275368	8/19 (42%)
		C2H2 Zn finger	281..301	CDD:275368	3/19 (16%)
		COG5048	305..>358	CDD:227381	17/52 (33%)
		C2H2 Zn finger	309..329	CDD:275368	6/19 (32%)
		C2H2 Zn finger	337..357	CDD:275368	5/19 (26%)
CG31441	NP_731558.1	zf-AD	7..82	CDD:285071	6/20 (30%)
		COG5048	<174..337	CDD:227381	43/157 (27%)
		C2H2 Zn finger	197..217	CDD:275370	8/19 (42%)
		C2H2 Zn finger	225..245	CDD:275368	3/19 (16%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	268..290	CDD:290200	9/21 (43%)
		C2H2 Zn finger	281..301	CDD:275368	5/19 (26%)
		C2H2 Zn finger	309..328	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000