Protein Alignment Ngly1 and Pngl

DIOPT Version :10

• Sequence 1: NP_067479.2
• Gene: Ngly1 / 59007
• MGIID: 1913276
• Length: 651
• Species: Mus musculus
• Sequence 2: NP_610192.1
• Gene: Pngl / 35527
• FlyBaseID: FBgn0033050
• Length: 631
• Species: Drosophila melanogaster
• Alignment Length: 643
• Identity: 218/643 - (33%)
• Similarity: 338/643 - (52%)
• Gaps: 87/643 - (13%)

Mouse    26 ETFLEASKLLLTYADNILRNPSDEKYRSIRIGNTAFSTRLLPVRGAVECLFEMGFEEGETHLIF- 89
            |.:|||.::||...:|||..|.:..:|:||..|.|...:||.:.|....|..:||....:...:
  Fly    30 EAYLEAVRILLVLLENILAQPENSMFRTIRQENKAIKEKLLSLPGCERLLEAIGFVRAPSSNAYT 94

Mouse    90 -PKKASVEQLQKIRDLIAIERSSRLDGSSKKVQFSQHPAAAKLPLEQSEDPAGLIRHSGNQTGQL 153
             |.:.|::|::|.||.::..|::.|:|:           .:|.|.:||
  Fly    95 LPTEVSLQQVKKYRDALSERRTAWLNGT-----------VSKSPPQQS----------------- 131

Mouse   154 PSLPSAPMVVGDS-------TILKVLQSN---IQHVQLYENPVLQEK-------ALTCIPVSELK 201
             :..:.|:.:..|       ...:||::|   :|.::||.:.|:|.:       ..|.|||.||.
  Fly   132 -TTSTTPLFIKPSVEYRHRIAFPRVLRTNNNFLQSLELYSDAVMQYEDNLLLATGRTLIPVEELT 195

Mouse   202 RKAQEKLFRAR-KLDKGTNVSDE----DFLLLELLHWFKEEFFRWVNNIVCSKCGGETRSRDEAL 261
            ..|.|||...: ::..|.....|    |.||:||::||..:||:|||||.|..||.|     |:.
  Fly   196 EMASEKLIDIQDQIASGERQEKEPCVRDLLLVELVNWFNTQFFQWVNNIPCRVCGSE-----ESR 255

Mouse   262 LPNDDELKWGAKNVENHYCDACQLSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRALGFEARY 326
            |...:  :.|...||...|  |...::|.|||:..:||.:|.|||||:|||||..||||.::||.
  Fly   256 LRRTE--REGDIRVEVTVC--CGQESKFYRYNDISQLLVSRKGRCGEYANCFTFLCRALDYDARI 316

Mouse   327 VWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYIIAFSKDEVVDVTWRYSCK 391
            |..:.|||||||||.:|.||||.|..|:|.|.||:|:.||.:.:.||:|:|:|::.||||||:..
  Fly   317 VHSHFDHVWTEVYSEAQMRWLHVDPSENVIDSPLMYQHGWKRHIDYILAYSRDDIQDVTWRYTND 381

Mouse   392 HDEVMSRRTKVKEELLRETINGLNKQRQLSLSESRRKELLQRIIVELVEFISPKTPRPGELGGRV 456
            |.:::..|....|:.:.:|::.:..:|:.:.:..|:..|.||.:.|::.....:.|...||.||.
  Fly   382 HQKILHLRKLCGEKEMVQTLDAIRAKRRQNCTADRKLFLSQRNMYEVIGLTLERKPTENELKGRS 446

Mouse   457 SGSLAWRVARGE---TGLERKEILFIPSENEKISKQFHLRYDIVRDRYIRVSDNNINIS------ 512
            ||||:||.:|||   |.:    .:|..|..|...:|.::||....|.|.|.:....:|:
  Fly   447 SGSLSWRQSRGEHTFTNI----FVFNLSATELQKRQLNVRYSCATDTYERYAKEGEHITILDSYK 507

Mouse   513 GWENGVWKMESIFRKVEKDWNMVYLARKEGSSFAYISWKFECGSAGLKVDTVSIRTSSQSFESGS 577
            .|:...:..::||||||:||.|.||||.|.:....|:|.|:.....|||.:.::...:::|..|.
  Fly   508 TWQKAQFSSKNIFRKVERDWKMAYLARLEDTDCGEIAWTFDFSKTNLKVKSYNLVFETKTFGDGK 572

Mouse   578 VRWKLRSETAQVNLLGDKNLRSYNDFSGATEVTLEAELSRGDGDVAWQHTQLFRQSLN 635
            :...:.:.....::            ..||...:.|:|:.|.||||||||||||||||
  Fly   573 ISVTVDATDGSASV------------ENATGFKIVAKLTGGKGDVAWQHTQLFRQSLN 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ngly1	NP_067479.2	PUB_PNGase	19..109	CDD:198417	27/84 (32%)
		Transglut_core	272..351	CDD:376628	42/78 (54%)
		Rad4	<335..>389	CDD:427539	30/53 (57%)
		PAW	454..648	CDD:461409	66/191 (35%)
Pngl	NP_610192.1	PUB	29..109	CDD:462790	25/78 (32%)
		Transglut_core	<278..341	CDD:376628	38/62 (61%)
		Rad4	<325..>383	CDD:427539	31/57 (54%)
		PAW	444..630	CDD:461409	66/191 (35%)