Protein Alignment BCHE and Nlg1

DIOPT Version :10

• Sequence 1: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_731172.2
• Gene: Nlg1 / 40913
• FlyBaseID: FBgn0051146
• Length: 1354
• Species: Drosophila melanogaster
• Alignment Length: 604
• Identity: 175/604 - (28%)
• Similarity: 262/604 - (43%)
• Gaps: 106/604 - (17%)

Human    34 IATKNGKVRGM--NLTVFGG--TVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCC 94
            |..|.|::.|:  ...|..|  .|..|||:|||:.|.|..||..|.:...|..:..|......|.
  Fly   158 IQVKQGRLMGITRRFQVTSGLRQVDQFLGLPYAEAPTGNRRFMPPGAPLPWQGLKIARHLPPVCP 222

Human    95 QNIDQSFPGFHGSEMWNP-------------NTDLSEDCLYLNVWIPAPK----PKNATVLIWIY 142
            |.:....|  ||||..:.             .|: ||||||||:::|..:    ||...||::::
  Fly   223 QKLPDLSP--HGSENMSRARHKHLSRLLPYLRTE-SEDCLYLNLYVPHEEPQSTPKQYAVLVYLH 284

Human   143 GGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQ 207
            |..|:  .:|.:.|||..|:....||||::|||:|.||||....:.....|..|.||..||.|::
  Fly   285 GESFE--WNSGNPYDGSVLSSYGEVIVVTVNYRLGVLGFLRPSIDAHNIANYALLDQIAALHWIK 347

Human   208 KNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTL 272
            :||.||||:...|||.|.|.|||.|:..::||.:..||.||||.|||..:.||.::  ::...|:
  Fly   348 ENIEAFGGDNSRVTLMGHSTGAACVNYLMVSPVASGLFHRAILMSGSAMSDWAASN--QSLQLTM 410

Human   273 NLAKLTGC------SRENETEIIKCLRNKDPQEILLNEAFVVPYG-TPLSVNFGPTVDGDFLTDM 330
            .:|....|      ..|::..::.|||::..|:||     .:|.. |..|.:.||.|||..:.:.
  Fly   411 QIAHALECPLNEHVEAEDDDVLLDCLRHRRYQDIL-----HIPTALTQFSTSLGPIVDGHVIPNQ 470

Human   331 PDILL--ELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFG 393
            |..::  ....|.:..:|.|:.:.|....|...|               .:|||:       |..
  Fly   471 PYKVMGHYTEHFSRYDLLFGITESESYHTLAALA---------------LEEGLR-------ENE 513

Human   394 KESILFHYTDWVDDQRPE-----------------------NYREALGDVVGDYNFICPALEFTK 435
            ::::|..|.....|.||:                       .:|:.:.|::.|...:.|.|:...
  Fly   514 RDNLLRFYMQSRFDIRPDLALAATLKKYQDMYNNPIKATNLEHRDVVLDILSDARVVGPLLQTGM 578

Human   436 KFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER-----RDNYTKAEEILSRSI 495
            ..::.....:.|.|.|.|:..|:......:.|.|:.|:||.||..     ..|||..|::||.::
  Fly   579 FHADVNRRNYMYVFGHNSATGPFAHLPHSIMGEELAFIFGAPLAAAGPFPSGNYTVQEKLLSEAV 643

Human   496 VKRWANFAKYGNPN-------------ETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQC 547
            :..|.||.|.|||.             |.......||.|....|.||.:....| :..|.|....
  Fly   644 MAYWTNFVKTGNPKAPWKGIFINSHALEWDRYDLDWPEFNRRAQAYLNIGIPPT-VGYKYRQIYM 707

Human   548 RFWTSFFPKVLEMTGNIDE 566
            .||....|..|.....|.|
  Fly   708 NFWNKELPDELNQIAAIQE 726

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	169/586 (29%)
		AChE_tetra	565..599	CDD:430146	1/2 (50%)
Nlg1	NP_731172.2	COesterase	157..710	CDD:395084	169/586 (29%)