Protein Alignment BCHE and Nlg3

DIOPT Version :10

• Sequence 1: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_731170.2
• Gene: Nlg3 / 40912
• FlyBaseID: FBgn0083963
• Length: 1159
• Species: Drosophila melanogaster
• Alignment Length: 676
• Identity: 191/676 - (28%)
• Similarity: 290/676 - (42%)
• Gaps: 173/676 - (25%)

Human    33 IIATKNGKVRGMNLTVFG---GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCC 94
            ||.|:||.:.|:.:.:.|   ..|.|:.|||||.||:|.|||..|.|...||.:..|.:::..|.
  Fly   157 IINTRNGAISGVIVQLDGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCP 221

Human    95 QNIDQSFPGFHGSEMWNPNTDL---------------------SEDCLYLNVWIP---------- 128
            |.:    |..|     |....|                     ||||||||:::|
  Fly   222 QRL----PDIH-----NETAALERMPKGRLEYLKRLLPYLQNQSEDCLYLNIYVPIQVGSRDSSG 277

Human   129 --------------------------------APKPKNATVLIWIYGGGFQTGTSSLHVYDGKFL 161
                                            :..|....||::::|..::  .:|.:.|||..|
  Fly   278 SSSSSSAGSSSSGSGGSSSSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYE--WNSGNPYDGSVL 340

Human   162 ARVERVIVVSMNYRVGALGFLALPGN--PEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFG 224
            |...:::||::|||:|.||||....:  .:.|.|.||.|...||.|:::|||||||:|.|:||.|
  Fly   341 ASYGQILVVTINYRLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAG 405

Human   225 ESAGAASVSLHLLSPG--SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKL-------TGC 280
            ...|||.|...:.|..  ...||.||||.|||..|||::.|         |.||.       ..|
  Fly   406 HGTGAACVHFLISSMAVPEGLLFNRAILMSGSGLAPWSLVS---------NPAKYAAIVAHHVNC 461

Human   281 SRE-NETEIIKCLRNKDPQEILLNEAFVVPYGTP-LSVNFGPTVD------GDFLTDMPDILLEL 337
            :.: ....::||||.|     .|::...||...| ....|||::|      ||::...|......
  Fly   462 ASDLPHAHLMKCLREK-----TLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQ 521

Human   338 GQFK-KTQILVGVNKDEGTAFL-VYGAPGFSKDNNSIITRK---------EFQEGL---KIFF-- 386
            .|.: .|....|:..:.|.|.. .:|.||  :..|.::.||         :...|:   :.||
  Fly   522 AQAQASTAAGNGLGGEAGIAAAGGWGTPG--QLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSF 584

Human   387 -PGVSEFGKES-----IL---------FH-----------YTDWVDD-QRPENYREALGDVVGDY 424
             .|..::|.|:     ||         ||           ||||... |.|.|.|:...:.:.|.
  Fly   585 NSGDVQYGIEADRRSRILKAYVRNTYTFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDA 649

Human   425 NFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPL-----ERRDNY 484
            ..:.||.:.....|....|::.|.|::::....:|:..|.:||.::.::||.||     ....||
  Fly   650 QVVAPAAQTVDLHSADHRNSYLYVFDYQTRFGDYPQRQGCIHGEDLPYIFGAPLVGGFNHFTRNY 714

Human   485 TKAEEILSRSIVKRWANFAKYGNPN---ETQNNS---------TSWPVFKSTEQKYLTLNTESTR 537
            ||.|..||..::..|:||.:.||||   ||::.|         ..|..::|..:|||..:|: .:
  Fly   715 TKTEISLSEVVMFYWSNFVRTGNPNEQMETEHGSRQERSRYKTIEWTAYESVHKKYLNFDTK-PK 778

Human   538 IMTKLRAQQCRFWTSFFPKVLEMTGN 563
            :....||.:..||.:..|.:.:..|:
  Fly   779 LKNHYRAHRLSFWLNLIPDLHKPGGD 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	187/661 (28%)
		AChE_tetra	565..599	CDD:430146
Nlg3	NP_731170.2	COesterase	154..791	CDD:395084	187/661 (28%)