back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BCHE and alpha-Est2

DIOPT Version :9

Sequence 1:	NP_000046.1	Gene:	BCHE / 590	HGNCID:	983	Length:	602	Species:	Homo sapiens
Sequence 2:	NP_001262345.1	Gene:	alpha-Est2 / 40908	FlyBaseID:	FBgn0015570	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	600	Identity:	174/600 - (28%)
Similarity:	266/600 - (44%)	Gaps:	130/600 - (21%)

- Green bases have known domain annotations that are detailed below.

Human    23 IGKSHTEDDIIIATKNGKVRGM-NLTVFG-GTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWN 85
            :...||   :|:.||.|:|||: ..||:. ....||.|||||:||:|.|||:.||....|..:.|
  Fly    27 LSTGHT---VILDTKYGQVRGLQRKTVYDKEPYFAFEGIPYAKPPVGDLRFRAPQPPEPWQGVLN 88

Human    86 ATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPK-PKNATVLIWIYGGGFQTG 149
            .|...:...|.           .|.....:.|||||:|||::.|.| .|...|::||||||||.|
  Fly    89 CTTNRSKPMQR-----------NMLLGIVEGSEDCLHLNVYVKALKSEKPLPVIVWIYGGGFQKG 142

Human   150 TSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNP--EAPGNMGLFDQQLALQWVQKNIAA 212
            .:|..:|...:..: :.|:.|::|||:.|||||:|. :|  :.|||.||.||.:||:|:.:|||.
  Fly   143 EASRDIYSPDYFMK-KPVVFVAINYRLAALGFLSLK-DPKLDVPGNAGLKDQVMALRWISQNIAH 205

Human   213 FGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKL 277
            |.|:|.::||.|||||:|||.:.:.:..:..||.:||:|||...:.|..:   ...|....||:.
  Fly   206 FNGDPNNITLMGESAGSASVHVMMTTEQTRGLFHKAIMQSGCALSEWVES---PDNNWAFRLAQN 267

Human   278 TGC-SRENETEIIK-----CLRN---KDPQEILLNE--AFVVPYGTPLSVNFGPTVDGDFLTD-- 329
            .|. ..|.:.:::.     |.|.   .|...|.|:|  :|       |...|||.:: .:.||
  Fly   268 LGYKGDEKDADVLSFLSKVCARQIAAIDQDVINLDEVRSF-------LLFAFGPVIE-PYETDHC 324

Human   330 -MP----DILLELGQFKKTQILVGVNKDEG--TAFLVYGAPGFSKDNNSIITRK----------- 376
             :|    |:|.| .......::||.|..||  :..||...|...|:.::|:.|:
  Fly   325 VVPKRHKDLLSE-AWGNDIPVIVGGNSFEGLFSYQLVRKDPWALKNFHNILPREVRETSSLEGQD 388

Human   377 -------------EFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFIC 428
                         |.||.:::       |...:|..|...|.|..|                ||.
  Fly   389 LLVRRLKQLYFNNEMQESMEM-------FEALNIFSHRQIWHDTHR----------------FIL 430

Human   429 PALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEW------------MGVMHGYEIEFVF-GLPLER 480
            ....:..|     ...:.|.|:..|     |.:            .||.|..|:.::| .:...:
  Fly   431 ARQSYAPK-----TPTYLYRFDFDS-----PHFNQFRRLVCGDRIRGVAHADELSYLFYNIIASK 485

Human   481 RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTE---QKYLTLNTESTRIMTKL 542
            .|..:...:.:.| :|..|.:||..||||..:..|..|...:..|   :|...::.:..  |..|
  Fly   486 LDKSSMEYKTIER-MVGMWTSFASSGNPNCPELGSAKWEAVQLKENAVEKCFNISHDLE--MRDL 547

Human   543 RAQQC-RFWTSFFPK 556
            ....| ..|.:|:|:
  Fly   548 PESDCLAVWDTFYPR 562

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.