Protein Alignment BCHE and alpha-Est3

DIOPT Version :10

• Sequence 1: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_524267.2
• Gene: alpha-Est3 / 40907
• FlyBaseID: FBgn0015571
• Length: 543
• Species: Drosophila melanogaster
• Alignment Length: 611
• Identity: 173/611 - (28%)
• Similarity: 272/611 - (44%)
• Gaps: 147/611 - (24%)

Human    30 DDIIIATKNGKVRGMNLT-VFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSC 93
            :.:.:.|.:|.|.|...| |:|....:|..|||||||:|.|||..|..:..||
  Fly     2 ESLQVNTTSGPVLGKQCTGVYGDEYVSFERIPYAQPPVGHLRFMAPLPVEPWS------------ 54

Human    94 CQNIDQSFPGFHGSEMWNPNTDLS--EDCLYLNVW---IPAPKPKNATVLIWIYGGGFQTG--TS 151
             |.:|.:.||....:..:.:..|.  ||||||||:   :.:|:|  ..::::.:||||:.|  |.
  Fly    55 -QPLDCTKPGQKPLQFNHYSKQLEGVEDCLYLNVYAKELDSPRP--LPLIVFFFGGGFEKGDPTK 116

Human   152 SLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPE--APGNMGLFDQQLALQWVQKNIAAFG 214
            .||..| .|:.|  .|:||:::||||.||||:| .:|.  .|||.||.||.||::|:::|...|.
  Fly   117 ELHSPD-YFMMR--DVVVVTVSYRVGPLGFLSL-NDPAVGVPGNAGLKDQLLAMEWIKENAERFN 177

Human   215 GNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTG 279
            |:||:||.||||||||||...:|:|.:..||.:||||||:....||:.::   :|....||...|
  Fly   178 GDPKNVTAFGESAGAASVHYLMLNPKAEGLFHKAILQSGNVLCSWALCTI---KNLPHRLAVNLG 239

Human   280 C-SRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSV---------NFGPTV-----DGDFLTD 329
            . |.|:.|:.:..    |..:.|..|..|.||  .||.         .|||.|     :...|.:
  Fly   240 MESAEHVTDAMVL----DFLQKLPGEKLVRPY--LLSAEEHLDDCVFQFGPMVEPYKTEHCALPN 298

Human   330 MPDILLELGQFKKTQILVGVNKDEGTAF---LVYG----APGFSKDNNSIIT--RKEFQEGLKIF 385
            .|..||:.....:..:|:     .||:|   |:|.    ||       .::|  :||.:..|.:
  Fly   299 HPQELLDKAWGNRIPVLM-----SGTSFEGLLMYARVQMAP-------YLLTSLKKEPEHMLPL- 350

Human   386 FPGVSEFGKESILFHYTDWVDDQR--PENYREALGDVVGDYNF-------ICPALEFTKKFSEWG 441
                                |.:|  |:.....||..:.:.:|       :.|  |..|.:.|:.
  Fly   351 --------------------DVKRNLPQALARHLGQRLQETHFGGNDPSAMSP--ESLKAYCEYA 393

Human   442 NNAFFYY----------------------------FEHRSSKLPWPEWMGVMHGYEIEFV-FGLP 477
            :...|::                            |.|:..|....:..||.|..:..:: :|..
  Fly   394 SYKVFWHPILKTLRSRVKSSSASTYLYRFDFDSPTFNHQRLKYCGDKLRGVAHVDDHSYLWYGDF 458

Human   478 LERRDNYTKAEEILSRSIVKRWANFAKYGNPN-----ETQNNSTSW-PVFKSTEQKYLTLNTEST 536
            ..:.|.:| .|.:....::....:||:..|||     :....:..| |:...:..:.|.: :|:.
  Fly   459 SWKLDKHT-PEFLTIERMIDMLTSFARTSNPNCKLIQDQLPRAKEWKPLNSKSALECLNI-SENI 521

Human   537 RIMTKLRAQQCRFWTSFFPKVLEMTG 562
            ::|.....|:.|.|.|    |.:.||
  Fly   522 KMMELPELQKLRVWES----VCQSTG 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	168/597 (28%)
		AChE_tetra	565..599	CDD:430146
alpha-Est3	NP_524267.2	alpha/beta hydrolases	2..535	CDD:473884	168/597 (28%)