Protein Alignment BCHE and alpha-Est5

DIOPT Version :10

• Sequence 1: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_001246965.1
• Gene: alpha-Est5 / 40905
• FlyBaseID: FBgn0261393
• Length: 543
• Species: Drosophila melanogaster
• Alignment Length: 569
• Identity: 151/569 - (26%)
• Similarity: 253/569 - (44%)
• Gaps: 102/569 - (17%)

Human    39 GKVRGM-NLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQN--IDQS 100
            |:::|: .|:::.....:|..||:|:||||.|||:.|.....||.:.:.|.||....|.  :.:.
  Fly    18 GQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLLTRE 82

Human   101 FPGFHGSEMWNPNTDLSEDCLYLNVW---IPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLA 162
            ..|             .||||||||:   :.:.||  ..|:::||||.|..|.::..:| |....
  Fly    83 IEG-------------GEDCLYLNVYSKQLKSEKP--LPVMVYIYGGAFTVGEATRELY-GPDYF 131

Human   163 RVERVIVVSMNYRVGALGFLALPGNP--EAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGE 225
            ..:.|::|::||||..||||:|. :|  :.|||.||.||.|||:||::.|:.|.|:..::|:|||
  Fly   132 MTKDVVLVTLNYRVDCLGFLSLK-DPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFGE 195

Human   226 SAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSREN-ETEII 289
            |||..|....:.:..:..||.:||..||:.:..||..   .|.:....||:..|.:.|| :.:::
  Fly   196 SAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANN---PAEDFAFRLAQQNGFTGENDDAKVL 257

Human   290 KCLRNKDPQEILLNEAFVVP--YGTPLSVNFGPTVDG----DFLTDMPDILLELGQFKKT-QILV 347
            :.|:.. |...|:|...:.|  ....|...|||||:.    |.:...|.:.:....:... .:::
  Fly   258 EYLQGV-PARDLVNHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVML 321

Human   348 GVNKDEGTAF---LVYGA--------PGFSKDNNSII--------TRKE----FQEGLKIFFPGV 389
            |     ||:|   .:|.|        ...|:|...::        :.||    .|..:|.:| |.
  Fly   322 G-----GTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENLEYSQRLMKAYF-GY 380

Human   390 SEFGKESILFHYTD-------WVDDQRPENYREALGDVVGDYNFICPALEFTK------KFSEWG 441
            |....| :|.:..|       |....|..|.|                |.:.|      :|....
  Fly   381 SPPSSE-LLLNMLDFYSYKIFWHGFNRTFNAR----------------LTYAKAPTYYYRFDFDS 428

Human   442 NNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYG 506
            .|..||..:....|:.    .||.|..::.::|......:.:.|.||......::..|..||...
  Fly   429 PNFNFYRAKFCGDKIK----TGVAHADDLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATS 489

Human   507 NPNETQNNSTSW-PVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFF 554
            |||..:.....| |..|:..::.:.::::.| |:.....::.:.|.:.:
  Fly   490 NPNCPEIGHLEWKPSTKNDPKRVINISSDVT-IIDLPEYEKLQIWDNLY 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	150/563 (27%)
		AChE_tetra	565..599	CDD:430146
alpha-Est5	NP_001246965.1	alpha/beta hydrolases	12..533	CDD:473884	150/563 (27%)