Protein Alignment BCHE and alpha-Est6

DIOPT Version :10

• Sequence 1: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_524262.1
• Gene: alpha-Est6 / 40902
• FlyBaseID: FBgn0015574
• Length: 568
• Species: Drosophila melanogaster
• Alignment Length: 634
• Identity: 171/634 - (26%)
• Similarity: 266/634 - (41%)
• Gaps: 160/634 - (25%)

Human     3 SKVTIICIRFLF------WFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLT-VFGGTVTAFLGIP 60
            |:..|.|.|||.      :....|...|.:   |..::....|.|:|..|: ::|....:|.|||
  Fly     9 SRSRIKCFRFLILRCCPGFKRFSCQSAGDA---DSKVVKLSVGSVKGRRLSGIYGDEFYSFEGIP 70

Human    61 YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDL--SEDCLYL 123
            :|:||||:.||...|    .:|.||:...|..     ::..|    .:|...:..:  |||||||
  Fly    71 FAKPPLGKARFVASQ----LADPWNSELDARQ-----ERPIP----LQMDRRSGKVVGSEDCLYL 122

Human   124 NVWI--------PAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG 180
            ||:.        |.|      |:::||||.|:||.:....|...:|...: |:.|..|||:.:||
  Fly   123 NVYTKHFNESEPPLP------VMVYIYGGAFRTGGAVKSKYGPDYLMSRD-VVYVLFNYRLCSLG 180

Human   181 FLALP-GNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSL 244
            ||::| |..:.|||.||.||.||||||.::|..|.|:|:::||||||||||||...:..|.:..|
  Fly   181 FLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHFMMCLPQAKGL 245

Human   245 FTRAILQSGSFNAPW-------------AVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKD 296
            |.:||:.|||..:||             |.::.||              ....|..|::.|||.:
  Fly   246 FHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYE--------------GPAEEVPILEFLRNVN 296

Human   297 PQEILLNEAFVVP----YG--TPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGT 355
            .:: |:...|:.|    :|  .|    |.|.|.|........::.|.... :..:|:|     ||
  Fly   297 AEK-LIGHDFISPRDRCFGFLNP----FAPVVGGLVAAPFQQLMKEAWSC-EVPLLLG-----GT 350

Human   356 AF--LVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENY----- 413
            :|  ||| .|....||..::...:.:..:              :|.|          |.|
  Fly   351 SFEGLVY-YPFCQLDNGYMLELLKHEPAM--------------VLPH----------ELYQSMSV 390

Human   414 --REALGDVVGDYNF---------ICPALE-FTKKFSEWGNN-------------AFFYYFEHRS 453
              |....||:..|::         |...|: |:.|....|.:             .:.|.|:..|
  Fly   391 EERNTAADVLVKYHYGPRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDS 455

Human   454 SKLPWPEWM-----------GVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGN 507
            .||   ..|           ||.|..::.::|....:.:......|.:..:.:|.....||:.|:
  Fly   456 PKL---NLMRNQLCGDDIKRGVCHADDLGYIFHKQAQAKQPLDSPEFLTIQRMVGILTTFARTGD 517

Human   508 PNETQNNSTSW-PVFKSTEQKYLTLNT-ESTRIMTKLRAQQCRFWTSFF 554
            ||..:.....| ||  ||:..:..||. :....:|::.....:.|...:
  Fly   518 PNCPETGPDPWMPV--STKSPFKALNIGQQVECVTQVEKDGLKVWNRLY 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	162/595 (27%)
		AChE_tetra	565..599	CDD:430146
alpha-Est6	NP_524262.1	COesterase	39..536	CDD:395084	159/571 (28%)