Protein Alignment BCHE and alpha-Est9

DIOPT Version :10

• Sequence 1: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_731165.2
• Gene: alpha-Est9 / 40897
• FlyBaseID: FBgn0015577
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 592
• Identity: 169/592 - (28%)
• Similarity: 281/592 - (47%)
• Gaps: 103/592 - (17%)

Human    28 TEDDIIIATKNGKVRGM-NLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYAN 91
            |.:..:::|..|.::|: ..:::|.:..:|..||:|:||:|.||:|.||....|:::       .
  Fly    28 TSEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEV-------R 85

Human    92 SCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKP-KNATVLIWIYGGGFQTGTSSLHV 155
            ||.....:........||    ||.|||||||||:.....| |...|::||||||||.|.:|...
  Fly    86 SCTSQGPKPLQKHFVFEM----TDGSEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFGEASREC 146

Human   156 YDGKFLARVERVIVVSMNYRVGALGF------------LALPG-----NPE--APGNMGLFDQQL 201
            |...:|.| |.|:|:|:|||:|.||.            ::|||     :||  .|||.||.||.|
  Fly   147 YSPDYLLR-EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVL 210

Human   202 ALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYE 266
            ||:||:.|.:.|||:..::|:||:|||:|||...:::..:|.||.:||..||:..:|||||   .
  Fly   211 ALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVT---P 272

Human   267 ARNRTLNLAKLTGCSRENET-EIIKCLRNKDPQEIL-LNEAFVVPYGTP--LSVNFGPTVDGDFL 327
            .||....||...|.:.||.| ::.:.|:|....||: .|....:.....  :..:|||.:: .::
  Fly   273 QRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIE-PYV 336

Human   328 TD------MPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFF 386
            |.      .|..::.........:::|...:||  .|:|..   :|.|...:..   .:..:...
  Fly   337 TSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEG--LLLYSE---TKTNPKCLNE---LDDCRFVV 393

Human   387 PGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEH 451
            |......:||.|..  ::.|..|...|        ||..   |:|:...::.:..::.:|::..:
  Fly   394 PIELNMDRESALCR--EYGDQLRQCYY--------GDKT---PSLDTLHEYLQMVSHEYFWFPIY 445

Human   452 RS--SKLPW----PEWM-----------------------GVMHGYEIEFVFGLPLERR-DNYTK 486
            |:  |:|.:    |.::                       |..||.::.::|...|.|: .|:|:
  Fly   446 RTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTR 510

Human   487 AEEILSRSIVKRWANFAKYGNPNETQNNSTSW-PVFKSTEQKY--LTLN-TESTRIMTKLRAQQC 547
            ..:.:.| :|..|.:||..||||........| ||..:..:|:  ..|| ::..:::.....::.
  Fly   511 EYKCIER-LVGLWTHFAACGNPNFDPEQEDLWQPVDPAAVEKHQLKCLNISDELKVIDVPDLKKL 574

Human   548 RFWTSFF 554
            ..|.|||
  Fly   575 MVWESFF 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	164/584 (28%)
		AChE_tetra	565..599	CDD:430146
alpha-Est9	NP_731165.2	COesterase	32..577	CDD:395084	164/582 (28%)