Protein Alignment BCHE and CG3841

DIOPT Version :10

• Sequence 1: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_609300.1
• Gene: CG3841 / 34278
• FlyBaseID: FBgn0032131
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 594
• Identity: 171/594 - (28%)
• Similarity: 274/594 - (46%)
• Gaps: 98/594 - (16%)

Human    11 RF--LFWFLLLCMLIG----KSHTEDDIIIATKNGKVRGMNLTVFGG-TVTAFLGIPYAQPPLGR 68
            ||  |.|.||| :|||    .:...||.::....|:::|..:..||. |:.||.||.|||.|:|:
  Fly     3 RFFQLTWALLL-ILIGFTTAVTFIGDDPVVELSLGRIQGDTMQSFGNKTIYAFRGIRYAQSPVGQ 66

Human    69 LRFKKPQSLTKWSD-IWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKP 132
            |||..|...|.|.| ::|||..:..|.|      ||....        :|||||.:||:..:.:.
  Fly    67 LRFANPVPETSWGDEVFNATSDSLVCPQ------PGVVSL--------MSEDCLKINVFTKSFED 117

Human   133 KNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLF 197
            | ..|:::|:||....|:.......|......:.|:.|:.|||:||||||: ..:.|..||.|..
  Fly   118 K-FPVMVYIHGGANVLGSGHSSYEAGPQYLLDQDVVFVAFNYRLGALGFLS-TNSSETKGNFGFL 180

Human   198 DQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVT 262
            ||.:||:||:.:|:.|||:|:.||:.|.|||:.:|||||.||.|..||.||||.|||....:.:.
  Fly   181 DQVMALEWVRDHISHFGGDPELVTIIGISAGSMAVSLHLASPLSAGLFHRAILMSGSATNHFDID 245

Human   263 SLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEIL----LNEAFVVPYGTPLSVNFGPTVD 323
            :|:..|    .||:..||...:.|::::||||:....|:    ..|.:.:     :::.:...:|
  Fly   246 NLFWTR----KLARELGCPMYDPTDVVECLRNETWTRIVEVCKAWETYQL-----VNMKWNYEID 301

Human   324 GDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPG 388
            |.||.:.|..|::.|.|.|..:|:....:|           |..:.|   ...|.|..|..|...
  Fly   302 GHFLHNHPTELIKEGNFNKVPLLISFTANE-----------FDYNAN---VHLENQHLLHDFASN 352

Human   389 VSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRS 453
            ..::..|..|:.:...:.::..:.|   |||...:.|     .|..:.|.:..::|:..:..||.
  Fly   353 FVDYAPELFLYRHDAQIGEKLKDFY---LGDNTTEIN-----SENIENFGQIFSDAYIGHGVHRL 409

Human   454 SKLP---WPEW----------------------MGVMHGYEIEFV-----FGLPLERRDNYTKAE 488
            .:|.   .|.:                      :||.|..::.:|     :|..:...|    ::
  Fly   410 VQLASHFTPVYYTRMDYVGDQSLSAPLNGENKPVGVGHADDLHYVLPGYWYGPLMAAND----SD 470

Human   489 EILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSF 553
            ..:...:...:.:|||.|.|   .|::..||...||..|.| .|...|::.:...:.:...|...
  Fly   471 VFMMERLTSWFTHFAKTGTP---LNSTDIWPPCNSTVLKML-YNGVVTQVGSPGYSNRYAVWDKL 531

Human   554 FPKVLEMTG 562
            ||...:..|
  Fly   532 FPTAAQGGG 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	157/555 (28%)
		AChE_tetra	565..599	CDD:430146
CG3841	NP_609300.1	COesterase	27..528	CDD:395084	157/555 (28%)