Protein Alignment BCHE and clt

DIOPT Version :10

• Sequence 1: NP_000046.1
• Gene: BCHE / 590
• HGNCID: 983
• Length: 602
• Species: Homo sapiens
• Sequence 2: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Alignment Length: 635
• Identity: 181/635 - (28%)
• Similarity: 287/635 - (45%)
• Gaps: 151/635 - (23%)

Human     9 CIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKK 73
            |.|.:|......|.: |...:..:::..:...|.|:.       ..:|||:|||:||:|.|||:.
  Fly     6 CGRLIFTRFCSSMKV-KVPVKQGVLVGRQKKLVNGLE-------YNSFLGVPYAEPPVGELRFRS 62

Human    74 PQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNT---DLSEDCLYLNVWIPAPKPKNA 135
            |:.|.::..            |.:|.|..| :.|...:|.|   ..|||||:|||:  |||.|:.
  Fly    63 PRPLERFQK------------QELDCSKEG-NVSYQRDPFTLEVAGSEDCLFLNVY--APKVKST 112

Human   136 ----TVLIWIYGGG--FQTGTSSLHVYDGKFLARV--ERVIVVSMNYRVGALGFLALPGNPEAPG 192
                .|::||:|||  |..|.|..|     |.|::  :.||||::|||:||||||:|| .....|
  Fly   113 RTPLPVMVWIHGGGFFFGNGNSDFH-----FPAKLMEQEVIVVTLNYRLGALGFLSLP-EEGIHG 171

Human   193 NMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNA 257
            ||||.||:|||:|||:|||:|.|:|.:|||||||||.:||.||..:..:..||.:||:|||:.|.
  Fly   172 NMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANM 236

Human   258 PWAVTSLYEARNRTLNLAKLTGCS--RENETEIIKCLRNK--DPQEILLNEAFVVPYGTP----- 313
            .|...:  ||..:|..||:|.|..  ..:...::..|:::  .|..||.|...|:   :|
  Fly   237 EWVFQN--EAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVL---SPDERRR 296

Human   314 -LSVNFGPTVDGDFLTDMPDILLE------------LGQFKKTQILVGVNKDEGTAFLVYG---A 362
             |...|.|.|:.   :..||..||            ||..   .:::|.|..||.|.:|..   .
  Fly   297 HLPFAFKPVVED---SSSPDRFLEQDIMELMHKKDCLGSM---PVIMGYNSAEGLAIVVKAKQKL 355

Human   363 PGFSKDNNSIITRK--------EFQEG---LKIFFPGVSEFGKESILFHYTDWVDDQRPENYREA 416
            ..:..|...::.|.        |.||.   ::.||.......||::                 :.
  Fly   356 EAYEDDLARLVPRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENM-----------------DN 403

Human   417 LGDVVGDYNF------------ICPA---LEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMH 466
            |.|:..||:|            .|..   |.|.:.....|.|.:...|::...:       ||.|
  Fly   404 LVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLR-------GVAH 461

Human   467 GYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTL 531
            ..:|.::|.:..:..: ..:.:.:::..:.:.|||||:.|.|:         |::|..::.:
  Fly   462 ADDICYLFQMAGDETE-MNRDDLMVTERLCEMWANFARDGKPS---------PIWKPVKKPH--- 513

Human   532 NTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWE-WKAGFHRWNN 580
            |.|..::...|           ..:.|:|..|.|....: |::.:.|:.:
  Fly   514 NGEPIQLDCLL-----------IDRELKMCSNPDGERMDFWRSMYRRYRS 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BCHE	NP_000046.1	COesterase	30..550	CDD:395084	170/581 (29%)
		AChE_tetra	565..599	CDD:430146	3/17 (18%)
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	174/607 (29%)