Protein Alignment RAF1 and ksr

DIOPT Version :10

• Sequence 1: NP_001341618.1
• Gene: RAF1 / 5894
• HGNCID: 9829
• Length: 668
• Species: Homo sapiens
• Sequence 2: NP_524236.2
• Gene: ksr / 40660
• FlyBaseID: FBgn0015402
• Length: 966
• Species: Drosophila melanogaster
• Alignment Length: 789
• Identity: 221/789 - (28%)
• Similarity: 333/789 - (42%)
• Gaps: 189/789 - (23%)

Human     4 IQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRT 68
            ::|....::|...||      |...||:          |:::...|..|:.:.|:....||...|
  Fly   224 VKGKNSALANSTNFK------SGRQSPS----------ATEELNSTQGSQLTLTLTPSPPNSPFT 272

Human    69 VVNVRNGMS------------------LHDCLMKALKVRGLQPECCAVFRL-------LHEHKGK 108
               ..:|:|                  .|..|:....|: :..|..|..||       .|.....
  Fly   273 ---PSSGLSSSLNGTPQRSRGTPPPARKHQTLLSQSHVQ-VDGEQLARNRLPTDPSPDSHSSTSS 333

Human   109 KARLDWNTDAASLIGEELQVDFLDHVPLTTH----NFARKTFLK----LAFCDICQKFLLNGF-R 164
            ...:|.||:|:| .|....|..:...|...|    :..:..|.|    :|.|.:|||.:.:.: :
  Fly   334 DIFVDPNTNASS-GGSSSNVLMVPCSPGVGHVGMGHAIKHRFTKALGFMATCTLCQKQVFHRWMK 397

Human   165 CQTCGYKFHEHCSTKVPTMC------VD-WSNIRQ----------------LLLFPNSTIG---- 202
            |..|.|..|:.|:..||..|      || :.:|::                ..|...||:|
  Fly   398 CTDCKYICHKSCAPHVPPSCGLPREYVDEFRHIKEQGGYASLPHVHGAAKGSPLVKKSTLGKPLH 462

Human   203 -------------DSGVPALPSLTMRRMRE--------SVSRMPVSSQHRYSTPHAFTF-NTSSP 245
                         .|..|:.|:|..:|.||        |.:.:|..|..::. |..|.| |.:..
  Fly   463 QQHGDSSSPSSSCTSSTPSSPALFQQRERELDQAGSSSSANLLPTPSLGKHQ-PSQFNFPNVTVT 526

Human   246 SSEGS-----LSQR-----------------QRSTSTPNVHM----------VSTTLPVDSRMIE 278
            ||.||     :|..                 ....|:.|.||          .||...:...::.
  Fly   527 SSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHMSSLIGSQTSNASTAATLTGSLVN 591

Human   279 NNNLSASPRAWSRRFCLRGRDA--------IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQ 335
            :...:::...:.|:....|.|.        ..:|..:.|...:|.|    ........:|||...
  Fly   592 STTTTSTCSFFPRKLSTAGVDKRTPFTSEYTDTHKSNDSDKTVSLS----GSASTDSDRTPVRVD 652

Human   336 RERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILK-- 398
            ......||...:|.|       |...|:|...:::|..|||.|.||||::..||||||||:|.
  Fly   653 STEDGDSGQWRQNSI-------SLKEWDIPYGDLLLLERIGQGRFGTVHRALWHGDVAVKLLNED 710

Human   399 -VVDPTPEQFQAFRNEVAVLRKTRHVNILLFMG-YMTKDNLAIVTQWCEGSSLYKHLHVQETKFQ 461
             :.|  ....:.||:|||..:.|||.|::|||| .|....|||||..|:|::||.::|.:..||.
  Fly   711 YLQD--EHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFA 773

Human   462 MFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPT 526
            |.:.:.||:|.||||.||||:.|||:|:::.|||:..|..: |.||||.:..........:..|.
  Fly   774 MNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVI-ITDFGLFSSTKLLYCDMGLGVPH 837

Human   527 GSVLWMAPEVIR-MQDNNP------FSFQSDVYSYGIVLYELMTGELPYSHINNRDQ----IIFM 580
            ..:.::|||:|| :|...|      |:..|||||:|.|.|||:.||..:     :||    ||:.
  Fly   838 NWLCYLAPELIRALQPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTF-----KDQPAESIIWQ 897

Human   581 VGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPK--INRSASEP 643
            |||| ....|:.|...  :.:|.|:..|....||.||.|.::||   ||:| |||  :.||.|.|
  Fly   898 VGRG-MKQSLANLQSG--RDVKDLLMLCWTYEKEHRPQFARLLS---LLEH-LPKKRLARSPSHP 955

Human   644 -SLHRAAHT 651
             :|.|:|.:
  Fly   956 VNLSRSAES 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAF1	NP_001341618.1	RBD_CRAF	55..131	CDD:340655	21/100 (21%)
		C1_A_C-Raf	136..187	CDD:410420	18/66 (27%)
		STKc_C-Raf	356..638	CDD:271051	120/298 (40%)
ksr	NP_524236.2	SAM_KSR1_N	33..86	CDD:466555
		SAM_KSR1	92..166	CDD:463916
		C1_KSR	370..418	CDD:410362	14/47 (30%)
		PK_KSR	678..946	CDD:270965	116/282 (41%)