DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAF1 and Raf

DIOPT Version :9

Sequence 1:	NP_001341618.1	Gene:	RAF1 / 5894	HGNCID:	9829	Length:	668	Species:	Homo sapiens
Sequence 2:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster

Alignment Length:	669	Identity:	305/669 - (45%)
Similarity:	395/669 - (59%)	Gaps:	80/669 - (11%)

- Green bases have known domain annotations that are detailed below.

Human    32 IVQQFGYQRRASDDGKLTD-----PSKTSNT--------IRVFLPNKQRTVVNVRNGMSLHDCLM 83
            |:||.....|......|||     |.....|        :|..|||:|||.|.|.:|:.|.|.||
  Fly   104 ILQQQRQLARVHHGNDLTDSLGSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISGVRLCDALM 168

Human    84 KALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTT---HNFARKT 145
            ||||:|.|.|:.|.|..   .|.|:.. :.|:||..:|..||:.|..||..|:.|   |...|||
  Fly   169 KALKLRQLTPDMCEVST---THSGRHI-IPWHTDIGTLHVEEIFVRLLDKFPIRTHIKHQIIRKT 229

Human   146 FLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDW--SNIRQLLLFPNSTIGDSGVPA 208
            |..|.||:.|::.|..||.|..|.::||:.|:.:||.:|..:  .:..||||..|.   |:|| .
  Fly   230 FFSLVFCEGCRRLLFTGFYCSQCNFRFHQRCANRVPMLCQPFPMDSYYQLLLAENP---DNGV-G 290

Human   209 LPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSS--PSSEGS---------LSQRQRSTSTPN 262
            .|.      |.:..|..:||:.|.....:...::||  |||...         :||..||.|.||
  Fly   291 FPG------RGTAVRFNMSSRSRSRRCSSSGSSSSSKPPSSSSGNHRQGRPPRISQDDRSNSAPN 349

Human   263 VHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAI----RSHSESASPSALSSSPNNLSPT 323
            |.:              ||:.:......|...::.|..:    ..||.|...|..|:..:|
  Fly   350 VCI--------------NNIRSVTSEVQRSLIMQARPPLPHPCTDHSNSTQASPTSTLKHN---- 396

Human   324 GWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKW 388
                        |.||..:....||.:. |..:.|...|.|.|.|:::..|||||||||||:..|
  Fly   397 ------------RPRARSADESNKNLLL-RDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHW 448

Human   389 HGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHL 453
            ||.||||.|.|..|:|.|.|||:||||:|:||||.|||||||.::|.:||||||||||||||||:
  Fly   449 HGPVAVKTLNVKTPSPAQLQAFKNEVAMLKKTRHCNILLFMGCVSKPSLAIVTQWCEGSSLYKHV 513

Human   454 HVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSG 518
            ||.||||::..||||.||.||||||||||||||||:|||||||||.|:||||||||||.|:||||
  Fly   514 HVSETKFKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDLSVKIGDFGLATAKTRWSG 578

Human   519 SQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGR 583
            .:|..|||||:|||||||||||:.||:|||||||::|||:|||:...|||.||:|:|||:|||||
  Fly   579 EKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQILFMVGR 643

Human   584 GYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRA 648
            |...||:|::..:.|:|:|||..||:|...::||||..:|:.:|.:..:||||:||||||:|.::
  Fly   644 GLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENMLRTLPKIHRSASEPNLTQS 708

Human   649 AHTEDINACTLTTSPRLPV 667
            ....|  ......||:.||
  Fly   709 QLQND--EFLYLPSPKTPV 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAF1	NP_001341618.1	Raf_RBD	57..131	CDD:176411	33/81 (41%)
		C1_1	139..187	CDD:278556	20/47 (43%)
		STKc_C-Raf	356..638	CDD:271051	185/281 (66%)
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514	32/73 (44%)
		C1_Raf	221..269	CDD:410361	19/47 (40%)
		STKc_Raf	435..687	CDD:270964	174/251 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	378	1.000	Domainoid score	I861
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	586	1.000	Inparanoid score	I1004
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49873
OrthoDB	1	1.010	-	-		D129822at33208
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		otm40979
orthoMCL	1	0.900	-	-		OOG6_100006
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.980