DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAF1 and lin-45

DIOPT Version :9

Sequence 1:	NP_001341618.1	Gene:	RAF1 / 5894	HGNCID:	9829	Length:	668	Species:	Homo sapiens
Sequence 2:	NP_001379593.1	Gene:	lin-45 / 177436	WormBaseID:	WBGene00003030	Length:	855	Species:	Caenorhabditis elegans

Alignment Length:	693	Identity:	274/693 - (39%)
Similarity:	375/693 - (54%)	Gaps:	121/693 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    58 IRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTD--AAS 120
            |.|.||..|.:.|.||.|.:..|.:.|.||.|.:.|:.|.| ....:.|.:...|....:  |:.
Worm   129 IMVHLPFDQHSRVEVRPGETARDAISKLLKKRNITPQLCHV-NASSDPKQESIELSLTMEEIASR 192

Human   121 LIGEELQV--DFLDHVPLTTHNFARKTFLKLAFCDICQK-FLLNGFRCQTCGYKFHEHCSTKVPT 182
            |.|.||.|  ::|:.|....|...|:||:....||:|.. ..:.||||:.|.:|||:.||:..|.
Worm   193 LPGNELWVHSEYLNTVSSIKHAIVRRTFIPPKSCDVCNNPIWMMGFRCEFCQFKFHQRCSSFAPL 257

Human   183 MC-------VDWSNIRQLL--------------------LFPNSTIGDSGVP--ALPSLTMRRMR 218
            .|       .:...:::|.                    |.|.|....:..|  :.|.||..:..
Worm   258 YCDLLQSVPKNEDLVKELFGIASQVEGPDRSVAEIVLANLAPTSGQSPAATPDSSHPDLTSIKRT 322

Human   219 ESVSRMP--VSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPV--------- 272
            ..|.|.|  ||.|           |.:|..|......|.||:|.||::.::....|
Worm   323 GGVKRHPMAVSPQ-----------NETSQLSPSGPYPRDRSSSAPNINAINDEATVQHNQRILDA 376

Human   273 --------DSRMIENNNLSASPR---AWSRRFCLRGRDAIRSHS-------ESASPSALSSSP-- 317
                    :||....:.||...|   .:.....|.|....|.|.       .|.|||:..|||
Worm   377 LEAQRLEEESRDKTGSLLSTQARHRPHFQSGHILSGARMNRLHPLVDCTPLGSNSPSSTCSSPPG 441

Human   318 -----------NNLSPTGWSQ---------PKTP---VPAQ---------RERAPVSGTQEKNKI 350
                       .|:|.:..|.         |.||   .|.|         |.|:|   .:..:..
Worm   442 GLIGQPTLGQSPNVSGSTTSSLVAAHLHTLPLTPPQSAPPQKISPGFFRNRSRSP---GERLDAQ 503

Human   351 RPR-GQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEV 414
            ||| .|:.....|||..:|.::..::|||||||||:|::.|.||:|.|.||||||.|..||:|||
Worm   504 RPRPPQKPHHEDWEILPNEFIIQYKVGSGSFGTVYRGEFFGTVAIKKLNVVDPTPSQMAAFKNEV 568

Human   415 AVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQE--TKFQMFQLIDIARQTAQGMD 477
            |||:||||:|:|||||::.:..:||:||||||||||:|:||||  .:|:|..:|||.:|.:.||:
Worm   569 AVLKKTRHLNVLLFMGWVREPEIAIITQWCEGSSLYRHIHVQEPRVEFEMGAIIDILKQVSLGMN 633

Human   478 YLHAKNIIHRDMKSNNIFLHEGL-TVKIGDFGLATVKSRW--SGSQQVEQPTGSVLWMAPEVIRM 539
            |||:|||||||:|:|||||.:.: |||||||||||||::|  :|.||.:|||||:||||||||||
Worm   634 YLHSKNIIHRDLKTNNIFLMDDMSTVKIGDFGLATVKTKWTVNGGQQQQQPTGSILWMAPEVIRM 698

Human   540 QDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRL 604
            ||:||::.||||||:||.:||:::..||||:|||||||:|||||||..||.||:..:.||:|.:|
Worm   699 QDDNPYTPQSDVYSFGICMYEILSSHLPYSNINNRDQILFMVGRGYLRPDRSKIRHDTPKSMLKL 763

Human   605 VADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPS-LH 646
            ..:|:...:.|||:|.::|.  .|....|||:.||.|.|: ||
Worm   764 YDNCIMFDRNERPVFGEVLE--RLRDIILPKLTRSQSAPNVLH 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAF1	NP_001341618.1	Raf_RBD	57..131	CDD:176411	25/76 (33%)
		C1_1	139..187	CDD:278556	19/55 (35%)
		STKc_C-Raf	356..638	CDD:271051	167/286 (58%)
lin-45	NP_001379593.1	RBD	128..203	CDD:128731	25/74 (34%)
		C1_Raf	211..260	CDD:410361	18/48 (38%)
		STKc_Raf	529..786	CDD:270964	159/258 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I636
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	435	1.000	Inparanoid score	I1045
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129822at33208
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		otm15683
orthoMCL	1	0.900	-	-		OOG6_100006
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.970