Protein Alignment RAF1 and Raf1

DIOPT Version :9

• Sequence 1: NP_001341618.1
• Gene: RAF1 / 5894
• HGNCID: 9829
• Length: 668
• Species: Homo sapiens
• Sequence 2: NP_001343262.1
• Gene: Raf1 / 110157
• MGIID: 97847
• Length: 668
• Species: Mus musculus
• Alignment Length: 668
• Identity: 649/668 - (97%)
• Similarity: 656/668 - (98%)
• Gaps: 0/668 - (0%)

Human     1 MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNK 65
            ||||||||||||||||.|||||||||||||||||||||||||||||||||.||||||||||||||
Mouse     1 MEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRVFLPNK 65

Human    66 QRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDF 130
            |||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||
Mouse    66 QRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAASLIGEELQVDF 130

Human   131 LDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLL 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 LDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLL 195

Human   196 FPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTST 260
            |||||:|||||||.||..||||||||||||.||||||||||||||||||||||||||||||||||
Mouse   196 FPNSTVGDSGVPAPPSFPMRRMRESVSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTST 260

Human   261 PNVHMVSTTLPVDSRMIENNNLSASPRAWSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGW 325
            ||||||||||.|||||||:|:|:|||||.||||||||||||||||||||||||||||||||||||
Mouse   261 PNVHMVSTTLHVDSRMIESNSLNASPRACSRRFCLRGRDAIRSHSESASPSALSSSPNNLSPTGW 325

Human   326 SQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHG 390
            |||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   326 SQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHG 390

Human   391 DVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHV 455
            ||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 DVAVKILKVVDPTPEQLQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHV 455

Human   456 QETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 QETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQ 520

Human   521 QVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGY 585
            |||||||||||||||||||||:||||||||||||||||||||.|||||:||||||||||||||||
Mouse   521 QVEQPTGSVLWMAPEVIRMQDDNPFSFQSDVYSYGIVLYELMAGELPYAHINNRDQIIFMVGRGY 585

Human   586 ASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAH 650
            ||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 ASPDLSRLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAH 650

Human   651 TEDINACTLTTSPRLPVF 668
            ||||||||||||||||||
Mouse   651 TEDINACTLTTSPRLPVF 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAF1	NP_001341618.1	Raf_RBD	57..131	CDD:176411	72/73 (99%)
		C1_1	139..187	CDD:278556	47/47 (100%)
		STKc_C-Raf	356..638	CDD:271051	276/281 (98%)
Raf1	NP_001343262.1	RBD_CRAF	55..131	CDD:340655	74/75 (99%)
		C1_1	139..184	CDD:365894	44/44 (100%)
		STKc_C-Raf	356..638	CDD:271051	276/281 (98%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83965333
Domainoid	1	1.000	512	1.000	Domainoid score	I7266
eggNOG	1	0.900	-	-		E2759_KOG0193
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48145
Inparanoid	1	1.050	1288	1.000	Inparanoid score	I3889
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49873
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001587
OrthoInspector	1	1.000	-	-		oto116278
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X994
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	15.360