DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MOK and pit1

DIOPT Version :9

Sequence 1:	NP_055041.1	Gene:	MOK / 5891	HGNCID:	9833	Length:	419	Species:	Homo sapiens
Sequence 2:	NP_593607.1	Gene:	pit1 / 2543071	PomBaseID:	SPAC3C7.06c	Length:	650	Species:	Schizosaccharomyces pombe

Alignment Length:	448	Identity:	135/448 - (30%)
Similarity:	211/448 - (47%)	Gaps:	100/448 - (22%)

- Green bases have known domain annotations that are detailed below.

Human     4 YKAIGKIGEGTFSEV-MKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPNILMLH 67
            |..:.|:|:|||..| :...........|.|.||::...:.....|||:.:|.||:.:.||:.:.
pombe    36 YNVVRKVGDGTFGSVYLATTKTPSKEVVAIKSMKKKLAKVSDATRLREVHSLLRLSENENIVNIF 100

Human    68 EVVFDRKSGSLALICELMDMNIYELIRGRRY-PLSEKKIMHYMYQLCKSLDHIHRNGIFHRDVKP 131
            ::..| :...|.::.|.:|.|:|:||..|:. ||:.:::...|.|:.|.|:|||.||.||||:||
pombe   101 DLYID-QFRCLHIVMEFLDCNLYQLISTRKNDPLTLEQVQDIMRQIFKGLNHIHTNGFFHRDMKP 164

Human   132 ENILIKQDV------LKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYTYKMDLWSAGC 190
            |||||..:.      :|:.|||..|.:.|:.|||||:|||||||||.||.|.:|::.:|:::|||
pombe   165 ENILISSNSDSSSFNVKIADFGLAREINSRPPYTEYVSTRWYRAPELLLRDSYYSFPVDIYAAGC 229

Human   191 VFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQSRAMNFDFPFKKGSGI----PLLT 251
            :.:|||:|||:|||.::.||:.|:.:::|:|.:       ||:...     .||.||    .||.
pombe   230 MAFEIATLQPIFPGNDDFDQLYKMCEILGSPDE-------QSQNTG-----DKGGGIWDRAELLA 282

Human   252 TNL----------------SP----QCLSLLHAMVAYDPDERIAAHQALQHPYF----------- 285
            ..|                ||    ...|:|..::.:||.:|..|...|...:.
pombe   283 NKLGISLPKMAPLDFGDLFSPPWNLAFASMLSQLLKWDPAKRPTAEMCLDLEFCRVSAPADAVAS 347

Human   286 --QEQRKTEKRALGSHRKAGFPEHPVAPEPLSNSCQISKEGR---------KQ------------ 327
              :..:.|:.|...|:    ||.....|:    .|...:|.|         ||
pombe   348 KEEVNKNTDFRVSISY----FPSSSSIPD----ECNTEEESRINPSTSKFLKQLNKGFNGFTKPF 404

Human   328 KQSLKQEEDRPKRRGPAYVMELPKLKLSGVVRLSSYSSPTLQSVLGSGTNGRVPVLRP 385
            ::|.||.::|             |.|.|...:.|..|.....|:..|.....:|.:||
pombe   405 RKSRKQSKNR-------------KNKSSVATQFSEESEDIADSITSSTFFPVLPQIRP 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MOK	NP_055041.1	STKc_MOK	4..285	CDD:270825	110/312 (35%)
		S_TKc	4..285	CDD:214567	110/312 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	285..344		15/92 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..419
pit1	NP_593607.1	S_TKc	36..335	CDD:214567	110/311 (35%)
pit1	NP_593607.1	STKc_MAK_like	36..332	CDD:270824	109/308 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0661
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770