Protein Alignment RAD21 and MCD1

DIOPT Version :10

• Sequence 1: NP_006256.1
• Gene: RAD21 / 5885
• HGNCID: 9811
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_010281.1
• Gene: MCD1 / 851561
• SGDID: S000002161
• Length: 566
• Species: Saccharomyces cerevisiae
• Alignment Length: 700
• Identity: 141/700 - (20%)
• Similarity: 237/700 - (33%)
• Gaps: 252/700 - (36%)

Human     9 SKRGPLAKIWLAAHWDK----KLTKAHVFE----------CNLESSVESIISPKVKMALRTSGHL 59
            :.:||||:||||::...    .:.:.|:.|          |:.||.....|:      |||||.|
Yeast    16 TNKGPLAQIWLASNMSNIPRGSVIQTHIAESAKEIAKASGCDDESGDNEYIT------LRTSGEL 74

Human    60 LLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDL 124
            |.|:||:|.::|.:||.|..:...||.|.|:.........||   .|.:|
Yeast    75 LQGIVRVYSKQATFLLTDIKDTLTKISMLFKTSQKMTSTVNR---LNTVT--------------- 121

Human   125 DDIDVAQQFSLNQSRVEEITMREEVGNISIL-------------------QENDFGDFGMDDREI 170
                          ||.::.:.:.|....:|                   |||..      :|::
Yeast   122 --------------RVHQLMLEDAVTEREVLVTPGLEFLDDTTIPVGLMAQENSM------ERKV 166

Human   171 ---------MREGSAFEDDDMLVSTTTSNLLLE----------------SEQSTSNLNEKINHLE 210
                     :..|..|..|:.......|::.|:                :.||:.|.:...|:::
Yeast   167 QGAAPWDTSLEVGRRFSPDEDFEHNNLSSMNLDFDIEEGPITSKSWEEGTRQSSRNFDTHENYIQ 231

Human   211 YEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSE----AGVMLPEQPAH--DDMDEDDN 269
            .:|...||....|.|.|| .:|...|||    ||..::.:    ...::.|:|..  .|:|.:..
Yeast   232 DDDFPLDDAGTIGWDLGI-TEKNDQNND----DDDNSVEQGRRLGESIMSEEPTDFGFDLDIEKE 291

Human   270 VSMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDS 334
            ...|..|            |:||..|              :...|:|..:|..||:.....::|.
Yeast   292 APAGNID------------TITDAMT--------------ESQPKQTGTRRNSKLLNTKSIQIDE 330

Human   335 KTIR----AQLSDYSDIVTTLDLAP-----PTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFT 390
            :|..    |..:.|.:..:...|.|     .||:|  |.|.  .|.:..||      :.:||.|
Yeast   331 ETENSESIASSNTYKEERSNNLLTPQPTNFTTKRL--WSEI--TESMSYLP------DPILKNF- 384

Human   391 RCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRD-VIDEPIIEEPSRLQES 454
                 |..|.|:||:                           .|..|: .|:||.:.....|.:.
Yeast   385 -----LSYESLKKRK---------------------------IHNGREGSIEEPELNVSLNLTDD 417

Human   455 VMEASRTN-------IDESAMPPPPPQGVKRKAGQIDPEPVMPPQQV-------EQMEIPPVELP 505
            |:..:.||       .|..:...|...|:.        |...|.:.:       ||..|...::.
Yeast   418 VISNAGTNDNSFNELTDNMSDFVPIDAGLN--------EAPFPEENIIDAKTRNEQTTIQTEKVR 474

Human   506 PEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRA 570
            |.......:.|.::..:..||..:|||                             .:...:.::
Yeast   475 PTPGEVASKAIVQMAKILRKELSEEKE-----------------------------VIFTDVLKS 510

Human   571 LAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDI 620
            .|.|..|:|:         :::|:..|:..|.|..:..|.|:|.|.:.:|
Yeast   511 QANTEPENIT---------KREASRGFFDILSLATEGCIGLSQTEAFGNI 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAD21	NP_006256.1	Rad21_Rec8_N	1..104	CDD:461446	35/108 (32%)
		Required for interaction with SMARCA5. /evidence=ECO:0000269|PubMed:12198550	126..282		36/205 (18%)
		Interaction with NIPBL. /evidence=ECO:0000269|PubMed:32409525	154..171		5/44 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..285		5/28 (18%)
		Interaction with WAPL and PDS5B. /evidence=ECO:0000269|PubMed:19696148	287..403		29/124 (23%)
		Rad21_Rec8_M_NXP1-like	316..395	CDD:439294	21/87 (24%)
		Interaction with STAG1. /evidence=ECO:0000269|PubMed:19696148	362..403		11/40 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..489		13/73 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..558		5/40 (13%)
		Rad21_Rec8	574..628	CDD:335912	11/46 (24%)
MCD1	NP_010281.1	Rad21_Rec8_N	17..108	CDD:461446	33/96 (34%)
		Rad21_Rec8_M_ScScc1p-like	315..394	CDD:439293	24/94 (26%)
		Rad21_Rec8	505..559	CDD:335912	12/55 (22%)