Protein Alignment RAD21 and rad21b

DIOPT Version :10

• Sequence 1: NP_006256.1
• Gene: RAD21 / 5885
• HGNCID: 9811
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_001038585.1
• Gene: rad21b / 566831
• ZFINID: ZDB-GENE-060503-223
• Length: 637
• Species: Danio rerio
• Alignment Length: 649
• Identity: 511/649 - (78%)
• Similarity: 561/649 - (86%)
• Gaps: 30/649 - (4%)

Human     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVR 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVR 65

Human    66 IYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVA 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish    66 IYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVA 130

Human   131 QQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTTTSNLLLES 195
            |||:|||||||||||||||||:|:||||||.||||||||:|||..||| .|::...:.|||||||
Zfish   131 QQFTLNQSRVEEITMREEVGNLSLLQENDFADFGMDDREMMREEGAFE-VDIIHGASASNLLLES 194

Human   196 EQSTSNLNEKINHLEYEDQYKDDNFG----EGNDGGILDDKLISNND-GGIFDDPPALSEAGVML 255
            |.|:..:.:|.||||| |||||| ||    |..:||:|.|||:||.| |||||||||:.| |||:
Zfish   195 ESSSVQIADKTNHLEY-DQYKDD-FGDNPMESTEGGMLVDKLLSNEDGGGIFDDPPAIPE-GVMM 256

Human   256 PEQPAHDDMDEDDNVS-MGGPDSPDSVDPVEPMPTMTD---QTTLVPNEEEAFALEPIDITVKET 316
            |:....||.|:.||:| .|||||||| .||||:|||||   |||||.||||||||||||||||||
Zfish   257 PQDHGADDDDDFDNLSPAGGPDSPDS-GPVEPLPTMTDQTEQTTLVHNEEEAFALEPIDITVKET 320

Human   317 KAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLW 381
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   321 KAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLW 385

Human   382 NNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIE 446
            |:||||:||||||||||::|||||||||||:||||||:.||||||||  :..:||||:||:.|:|
Zfish   386 NSRLLKMFTRCLTPLVPDELRKRRKGGEADSLDEFLKDLENPEVPRE--EALNQQRDIIDQTILE 448

Human   447 EPSRLQESVMEASRTNIDESAMPPPP-PQGVKRKAGQIDPEPVMPPQQ--------VEQMEIPPV 502
            |||.||.|.||.|||.:|||.||||. |:|.||||.  |.||.:|..:        .:.:.:|.|
Zfish   449 EPSVLQASAMEGSRTTLDESVMPPPSGPRGQKRKAQ--DGEPALPMLEDDRSSIVSTQHVSLPQV 511

Human   503 ELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGL 567
            |||||||.||.||||:|:|:.||.|:|   |:||:|||:|:...|||||||||||||||||||||
Zfish   512 ELPPEEPVNIAQLIPDLDLIGEKSKDK---KDDDDEEEEEEGQSGDQDQEERRWNKRTQQMLHGL 573

Human   568 QRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII 631
            ||.:|||||||||||:||||.|:||||||||||||||||||:||.|:|||||||||||||||||
Zfish   574 QRVIAKTGAESISLLDLCRNNNKKQAAAKFYSFLVLKKQQAVELRQDEPYSDIIATPGPRFHII 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAD21	NP_006256.1	Rad21_Rec8_N	1..104	CDD:461446	102/102 (100%)
		Required for interaction with SMARCA5. /evidence=ECO:0000269|PubMed:12198550	126..282		108/161 (67%)
		Interaction with NIPBL. /evidence=ECO:0000269|PubMed:32409525	154..171		14/16 (88%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..285		15/27 (56%)
		Interaction with WAPL and PDS5B. /evidence=ECO:0000269|PubMed:19696148	287..403		109/118 (92%)
		Rad21_Rec8_M_NXP1-like	316..395	CDD:439294	76/78 (97%)
		Interaction with STAG1. /evidence=ECO:0000269|PubMed:19696148	362..403		36/40 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..489		41/66 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..558		24/40 (60%)
		Rad21_Rec8	574..628	CDD:335912	47/53 (89%)
rad21b	NP_001038585.1	Rad21_Rec8_N	1..104	CDD:461446	102/102 (100%)
		Rad21_Rec8_M_NXP1-like	320..399	CDD:439294	76/78 (97%)
		Rad21_Rec8	580..634	CDD:335912	47/53 (89%)