DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAD21 and vtd

DIOPT Version :9

Sequence 1:	NP_006256.1	Gene:	RAD21 / 5885	HGNCID:	9811	Length:	631	Species:	Homo sapiens
Sequence 2:	NP_001015132.1	Gene:	vtd / 3354896	FlyBaseID:	FBgn0260987	Length:	715	Species:	Drosophila melanogaster

Alignment Length:	759	Identity:	294/759 - (38%)
Similarity:	390/759 - (51%)	Gaps:	180/759 - (23%)

- Green bases have known domain annotations that are detailed below.

Human     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVR 65
            |||.|.:|:|:||||:||||||||||:|||||||.|:|.|||.|:.||||:||||||||||||||
  Fly     1 MFYEHIILAKKGPLARIWLAAHWDKKITKAHVFETNIEKSVEGILQPKVKLALRTSGHLLLGVVR 65

Human    66 IYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVA 130
            ||.||||||||||||||:|||||||||:|||||.:|||..|||||||.|||||..||:|:|||:.
  Fly    66 IYSRKAKYLLADCNEAFVKIKMAFRPGMVDLPEGHREANVNAITLPEVFHDFDTALPELNDIDIE 130

Human   131 QQFSLNQSRVEEITMREEVGNISI-LQENDFGDFGMDDR--EIMREGSAFEDDDMLVSTTTSNLL 192
            .|||:||||.:||||||:.|::|: ||::.|||.|.:..  ||:|
  Fly   131 AQFSINQSRADEITMREDYGSLSLSLQDDGFGDIGFEAETPEIIR-------------------- 175

Human   193 LESEQSTSNLNEKI------NHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDD---PPAL 248
               ....||:|:||      .::|..|.:..|...         |...|..||..|.|   .|||
  Fly   176 ---CSIPSNINDKIFDNDVLENIESLDPHSLDAHA---------DMPGSRLDGDGFGDSFGQPAL 228

Human   249 SEAGVM-LPEQPAH------------DDMDED--DNVSMGGPDSPDSVDPVE------------- 285
            .|..:. .|.||..            ||.|||  ||:......:...|:.:|
  Fly   229 FEDDLFGDPSQPVEQITKESTTVLNADDSDEDAIDNIHNVPSPATSLVNSIEDEKEENNLNGHAS 293

Human   286 -----PMPTMTDQTTLVPNEEEAFALEPIDITVKE--TKAKRKRKLIVDSVKELDSKTIRAQLSD 343
                 ||    ::.|||.||:|.|||.|:|:::.:  ||||||||||:|.:|.:..:.::|||:|
  Fly   294 VSENVPM----NEITLVQNEDEGFALAPLDVSMYKGVTKAKRKRKLIIDEIKNISGEEMKAQLAD 354

Human   344 YSDIVTTLDLAPPTKKLMMWKETGGVEKLFSL-----PAQPLWNNRLLKLFTRC-----LTPLVP 398
            .|||:||||||||||:||.|||||||||||||     ||:.|:.|...:||:..     .:.:||
  Fly   355 TSDILTTLDLAPPTKRLMYWKETGGVEKLFSLPSRSIPARALFGNYNRQLFSHSTFFEDFSSVVP 419

Human   399 EDL--------------------RKRRKGGEADNL------DEFLKEFENPEVPREDQQQQHQQR 437
            .::                    .::||.....||      |..::..|.|||.|.:    |:..
  Fly   420 MEILALEFYTKENENALIIFNKKGRKRKNDNMSNLFLDHVPDSVVQSLEAPEVLRAN----HKSL 480

Human   438 DVIDEPIIEEPSRLQESV-MEASRTNIDESAMP-----------------PPPPQGVKRKAG--- 481
            .| ....:|..|:.|||: .:...|..|....|                 |..|:.:..:.|
  Fly   481 GV-STVSVEIVSKEQESISCQNELTFFDNMRSPDLLSLNEMEQFSSINELPLTPRNMNHEMGDDF 544

Human   482 -QIDPEPV------MPPQ--QVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEK------ 531
             |.|..|.      ..||  .:.:|:...| :|.::...|........:|.:....|..
  Fly   545 NQGDSTPAGLDHGHATPQHGNIGEMDHDSV-IPTKKTAVILNESVGTSVLSDNGVSKRTNNILKG 608

Human   532 -----------EKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQ-RALAKTGAESISLLEL 584
                       :...||:.|:|.    |:..|||..|||...:...:: ..:||   :|:.|.:|
  Fly   609 WDNYEIPSFVGQNHGDEQMENET----DEQFEERVLNKRAAHLFIDVRAHFIAK---DSLELSQL 666

Human   585 CRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRF 628
            ....:|||||.||||.|||||.:.:.:.|..||:||..|.||.|
  Fly   667 TSGNSRKQAAQKFYSLLVLKKFKVLHIDQSAPYADITITRGPTF 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAD21	NP_006256.1	Rad21_Rec8_N	1..104	CDD:398479	83/102 (81%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..285		10/40 (25%)
		Interaction with WAPL and PDS5B. /evidence=ECO:0000269\|PubMed:19696148	287..403		64/147 (44%)
		Interaction with STAG1. /evidence=ECO:0000269\|PubMed:19696148	362..403		21/70 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	423..489		20/93 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..558		10/57 (18%)
		Rad21_Rec8	574..628	CDD:335912	25/53 (47%)
vtd	NP_001015132.1	Rad21_Rec8_N	1..106	CDD:282655	84/104 (81%)
vtd	NP_001015132.1	Rad21_Rec8	657..710	CDD:282654	27/55 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157847
Domainoid	1	1.000	186	1.000	Domainoid score	I3373
eggNOG	1	0.900	-	-		E1_KOG1213
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38161
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253899at2759
OrthoFinder	1	1.000	-	-		FOG0001363
OrthoInspector	1	1.000	-	-		otm40914
orthoMCL	1	0.900	-	-		OOG6_103388
Panther	1	1.100	-	-	LDO	PTHR12585
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.760