Protein Alignment RAD21 and rad21

DIOPT Version :10

• Sequence 1: NP_006256.1
• Gene: RAD21 / 5885
• HGNCID: 9811
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_588151.1
• Gene: rad21 / 2539447
• PomBaseID: SPCC338.17C
• Length: 628
• Species: Schizosaccharomyces pombe
• Alignment Length: 701
• Identity: 184/701 - (26%)
• Similarity: 288/701 - (41%)
• Gaps: 180/701 - (25%)

Human     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPK-VKMALRTSGHLLLGVV 64
            |||:..:|||:|||||:||||||:|||:|......::|.||.:|::.: ..||||.||.|:||||
pombe     1 MFYSEAILSKKGPLAKVWLAAHWEKKLSKVQTLHTSIEQSVHAIVTEETAPMALRLSGQLMLGVV 65

Human    65 RIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPE--------ENREAAYNA--ITLPEEFHDFDQ 119
            |||.|||:|||.||.||.:::||:|:||.||:.|        :.::|...:  :||||...:||.
pombe    66 RIYSRKARYLLEDCTEALMRLKMSFQPGQVDMIEPATALQSLKGKDAVTQSANLTLPETITEFDL 130

Human   120 PLPD----------------------LDDIDV-------AQQFSLNQSRVEEITMREEVGNISIL 155
            .:||                      |..:.:       :.|.|:...|..::.....:|
pombe   131 LVPDSTFDFQWSQLLRTPSRSSNTLELHSLPISSSPSFPSSQLSIEAGRNAQVESGFSLG----- 190

Human   156 QENDFGDFGMDDR---EIMREGSA-----FEDDDMLVS------------TTTSNLLLESEQSTS 200
              ..|...|.|.:   .|...|:|     ..|:...:|            |..|.::  ..|.|.
pombe   191 --ESFAHVGNDMQFHLPISNSGAATPRSVHSDNQSQISIEVGRDAPAAAATDLSGII--GPQMTK 251

Human   201 NLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLIS-----NNDGGIFD--------DPPALSEAG 252
            :....:.|........   .|    |..|||:|::     |.|.|:.|        :.||: ||.
pombe   252 SPASSVTHFSTPSMLP---IG----GTSLDDELLAPVDDLNLDLGLDDLLGDEQGANAPAI-EAD 308

Human   253 VMLPEQPAH--DDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKE 315
            ........|  .|:.|||:       |..:...||....:...|  .|.:|:          :..
pombe   309 EQAETSSIHLPSDIMEDDS-------SRPAAAGVEEGQVVESAT--APQQEK----------INP 354

Human   316 TKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPL 380
            .|..|:::.|:|.|.||.||.::.||:|.|.|.:.|.|           .|..:  :|:......
pombe   355 QKTVRRQRAIIDPVTELSSKQMKKQLADTSSITSPLCL-----------NTSSI--VFNATVNFT 406

Human   381 WNNRL-LKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPI 444
            .|.:. ..:|:..|.|.|.|.|       :||.....|::.:| |.|.|.:..:||:.|...|.
pombe   407 RNGKFNTSIFSSNLNPKVNELL-------QADFKQAILRKRKN-ESPEEVEPAKHQRTDTSTEN- 462

Human   445 IEEPSRL--QESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPE-------PVMPPQQVEQ--ME 498
             :|.:.:  .|.:..|...||.|:|:...|.:.|.:..|:. ||       ||...:..:.  .:
pombe   463 -QETAEVLDPEEIAAAELANITEAAIATLPQETVVQPEGEA-PELGSPMGFPVTALESADDSLFD 525

Human   499 IPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQM 563
            .|||            ::.|.:||       ..|:.|....|...:|...:|....:|:..|:
pombe   526 APPV------------MLDEADLL-------GSERLDSSVSEALPSSQTAKDSLRNKWDPYTE-- 569

Human   564 LHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQE 614
                        .|.:|...|....||::|...|:..|||..:..|.:.|:
pombe   570 ------------GEKVSFQTLSAGCNREEAVQLFFDVLVLATKDVISVKQD 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAD21	NP_006256.1	Rad21_Rec8_N	1..104	CDD:461446	57/111 (51%)
		Required for interaction with SMARCA5. /evidence=ECO:0000269|PubMed:12198550	126..282		37/197 (19%)
		Interaction with NIPBL. /evidence=ECO:0000269|PubMed:32409525	154..171		3/19 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..285		6/28 (21%)
		Interaction with WAPL and PDS5B. /evidence=ECO:0000269|PubMed:19696148	287..403		28/116 (24%)
		Rad21_Rec8_M_NXP1-like	316..395	CDD:439294	21/79 (27%)
		Interaction with STAG1. /evidence=ECO:0000269|PubMed:19696148	362..403		9/41 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..489		20/74 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..558		9/40 (23%)
		Rad21_Rec8	574..628	CDD:335912	12/41 (29%)
rad21	NP_588151.1	Rad21_Rec8_N	1..97	CDD:461446	55/95 (58%)
		Rad21_Rec8_M_SpRad21p-like	356..439	CDD:439290	28/102 (27%)
		Rad21_Rec8	568..623	CDD:335912	13/55 (24%)