Protein Alignment RAD21 and Rad21

DIOPT Version :10

• Sequence 1: NP_006256.1
• Gene: RAD21 / 5885
• HGNCID: 9811
• Length: 631
• Species: Homo sapiens
• Sequence 2: NP_033035.3
• Gene: Rad21 / 19357
• MGIID: 108016
• Length: 635
• Species: Mus musculus
• Alignment Length: 635
• Identity: 614/635 - (96%)
• Similarity: 623/635 - (98%)
• Gaps: 4/635 - (0%)

Human     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVR 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVR 65

Human    66 IYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVA 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    66 IYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVA 130

Human   131 QQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTTTSNLLLES 195
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||:.||||||.
Mouse   131 QQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTSASNLLLEP 195

Human   196 EQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPA 260
            ||||||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 EQSTSNLNEKMNHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPA 260

Human   261 HDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLI 325
            |||||||||.|:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 HDDMDEDDNGSLGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLI 325

Human   326 VDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFT 390
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
Mouse   326 VDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFFLPAQPLWNNRLLKLFT 390

Human   391 RCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQ----QRDVIDEPIIEEPSRL 451
            ||||||||||||||||||||||||||||||||||||||:||.|.|    ||||||||||||||||
Mouse   391 RCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREEQQPQQQQPQPQRDVIDEPIIEEPSRL 455

Human   452 QESVMEASRTNIDESAMPPPPPQGVKRKAGQIDPEPVMPPQQVEQMEIPPVELPPEEPPNICQLI 516
            |:||||||||.|:|||||||||||||||||||||||.:|||||||||||||||||||||||||||
Mouse   456 QDSVMEASRTTIEESAMPPPPPQGVKRKAGQIDPEPSIPPQQVEQMEIPPVELPPEEPPNICQLI 520

Human   517 PELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISL 581
            ||||||||||||||||||::|||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 PELELLPEKEKEKEKEKEEEEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISL 585

Human   582 LELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII 631
            ||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 LELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAD21	NP_006256.1	Rad21_Rec8_N	1..104	CDD:461446	102/102 (100%)
		Required for interaction with SMARCA5. /evidence=ECO:0000269|PubMed:12198550	126..282		149/155 (96%)
		Interaction with NIPBL. /evidence=ECO:0000269|PubMed:32409525	154..171		16/16 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..285		24/26 (92%)
		Interaction with WAPL and PDS5B. /evidence=ECO:0000269|PubMed:19696148	287..403		114/115 (99%)
		Rad21_Rec8_M_NXP1-like	316..395	CDD:439294	77/78 (99%)
		Interaction with STAG1. /evidence=ECO:0000269|PubMed:19696148	362..403		39/40 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..489		59/69 (86%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..558		38/40 (95%)
		Rad21_Rec8	574..628	CDD:335912	53/53 (100%)
Rad21	NP_033035.3	Rad21_Rec8_N	1..104	CDD:461446	102/102 (100%)
		Required for interaction with SMARCA5. /evidence=ECO:0000250|UniProtKB:O60216	126..282		149/155 (96%)
		Interaction with NIPBL. /evidence=ECO:0000250|UniProtKB:O60216	154..171		16/16 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..285		24/26 (92%)
		Interaction with WAPL and PDS5B. /evidence=ECO:0000250	287..403		114/115 (99%)
		Rad21_Rec8_M_NXP1-like	316..395	CDD:439294	77/78 (99%)
		Interaction with STAG1. /evidence=ECO:0000250	362..403		39/40 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..496		60/72 (83%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..563		39/41 (95%)
		Rad21_Rec8	578..632	CDD:335912	53/53 (100%)