Protein Alignment RAD21 and rad21

DIOPT Version :10

• Sequence 1: NP_006256.1
• Gene: RAD21 / 5885
• HGNCID: 9811
• Length: 631
• Species: Homo sapiens
• Sequence 2: XP_031759353.1
• Gene: rad21 / 100492023
• XenbaseID: XB-GENE-1008099
• Length: 631
• Species: Xenopus tropicalis
• Alignment Length: 641
• Identity: 550/641 - (85%)
• Similarity: 588/641 - (91%)
• Gaps: 20/641 - (3%)

Human     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVR 65
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog     1 MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVR 65

Human    66 IYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVA 130
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 Frog    66 IYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVA 130

Human   131 QQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTTTSNLLLES 195
            |||||||||||||||||||.||:|||:||||||||||||:||||||||||  :::|:.||||||.
 Frog   131 QQFSLNQSRVEEITMREEVSNINILQDNDFGDFGMDDREMMREGSAFEDD--MLTTSASNLLLEP 193

Human   196 EQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPA 260
            |||||.||||.|||||:|||||||||||||||||||||:||:.|||||||||:.|.||.:||||.
 Frog   194 EQSTSQLNEKSNHLEYDDQYKDDNFGEGNDGGILDDKLLSNDAGGIFDDPPAMPEEGVAMPEQPV 258

Human   261 HDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLI 325
            |||:|:|||||||.||||||||||||:||||||||||||||||||||||||||||||||||||||
 Frog   259 HDDLDDDDNVSMGAPDSPDSVDPVEPLPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLI 323

Human   326 VDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFT 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||
 Frog   324 VDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNSRLLKLFT 388

Human   391 RCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPIIEEPSRLQESV 455
            |||||||||||:||||||||||||||||||||||||||:.:.|    ||||:||:||.||||||:
 Frog   389 RCLTPLVPEDLKKRRKGGEADNLDEFLKEFENPEVPREELRPQ----DVIDQPILEEASRLQESL 449

Human   456 MEASRTNIDESAMPPPPP-QGVKRKAGQIDPEPVMPPQQVE-QMEIPPVELPP--------EEPP 510
            ||.|||::||:.|||||| |||||.:.|::||||...|:.| .:|:||..|||        .|.|
 Frog   450 MEGSRTHLDETIMPPPPPQQGVKRDSLQMEPEPVPVMQETEPHIEMPPPPLPPPVELPSEVSETP 514

Human   511 NICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTG 575
            ||..|||||.|||||||||::|    ||||:|||:|.:|||||||||||||||||||||.|||||
 Frog   515 NINDLIPELNLLPEKEKEKDEE----EEEEEEDATGTEQDQEERRWNKRTQQMLHGLQRVLAKTG 575

Human   576 AESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII 631
            |||||||:||||||||||||||||||||||||||||||.||||||||||||||||:
 Frog   576 AESISLLDLCRNTNRKQAAAKFYSFLVLKKQQAIELTQAEPYSDIIATPGPRFHIV 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAD21	NP_006256.1	Rad21_Rec8_N	1..104	CDD:461446	102/102 (100%)
		Required for interaction with SMARCA5. /evidence=ECO:0000269|PubMed:12198550	126..282		128/155 (83%)
		Interaction with NIPBL. /evidence=ECO:0000269|PubMed:32409525	154..171		15/16 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..285		22/26 (85%)
		Interaction with WAPL and PDS5B. /evidence=ECO:0000269|PubMed:19696148	287..403		113/115 (98%)
		Rad21_Rec8_M_NXP1-like	316..395	CDD:439294	77/78 (99%)
		Interaction with STAG1. /evidence=ECO:0000269|PubMed:19696148	362..403		39/40 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	423..489		43/66 (65%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	517..558		29/40 (73%)
		Rad21_Rec8	574..628	CDD:335912	51/53 (96%)
rad21	XP_031759353.1	Rad21_Rec8_N	1..104	CDD:461446	102/102 (100%)
		Rad21_Rec8_M_NXP1-like	314..393	CDD:439294	77/78 (99%)
		Rad21_Rec8	574..628	CDD:335912	51/53 (96%)