DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mapk6 and rl

DIOPT Version :9

Sequence 1:	NP_113810.2	Gene:	Mapk6 / 58840	RGDID:	62087	Length:	720	Species:	Rattus norvegicus
Sequence 2:	NP_001015122.1	Gene:	rl / 3354888	FlyBaseID:	FBgn0003256	Length:	376	Species:	Drosophila melanogaster

Alignment Length:	347	Identity:	156/347 - (44%)
Similarity:	214/347 - (61%)	Gaps:	27/347 - (7%)

- Green bases have known domain annotations that are detailed below.

  Rat    14 FDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQS-VKHALREIKIIRRLDHDNI 77
            |::|.||:.|..:|.|..|:|.||.|...::|||||||...:.|: .:..||||.|:.|..|:||
  Fly    32 FEVGPRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRTLREITILTRFKHENI 96

  Rat    78 VKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKY 142
            :.:.:||         .|.|:.::..|||||..|||||..:|:...|..:|...|:||:||||||
  Fly    97 IDIRDIL---------RVDSIDQMRDVYIVQCLMETDLYKLLKTQRLSNDHICYFLYQILRGLKY 152

  Rat   143 IHSANVLHRDLKPANLFIN-TEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSP 206
            |||||||||||||:||.:| |.|  |||.|||||||.||.:.|.|.|:|.:.|:|||:|.::|:.
  Fly   153 IHSANVLHRDLKPSNLLLNKTCD--LKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 215

  Rat   207 NNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDM 271
            ..|||:||:|:.|||.||||:.:.:|.|.|.|:|:..||   .|:....|.:|..:|....||.:
  Fly   216 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL---GVLGSPSRDDLECIINEKARNYL 277

  Rat   272 T----EPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPF 332
            .    :|:.|..:|.|.....|||.|.::|||:|..|:..||||:|||:..|..|.|||::..||
  Fly   278 ESLPFKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPF 342

  Rat   333 HIEDEVDDI-------LLMDET 347
            .|..|.|||       |:.:||
  Fly   343 RINMENDDISRDALKSLIFEET 364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mapk6	NP_113810.2	STKc_MAPK4_6	14..355	CDD:143359	156/347 (45%)
		S_TKc	20..316	CDD:214567	137/301 (46%)
		SEG motif	189..191		0/1 (0%)
		FRIEDE motif	332..337		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..657
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	698..720
rl	NP_001015122.1	STKc_ERK1_2_like	32..366	CDD:270839	156/347 (45%)
rl	NP_001015122.1	S_TKc	38..326	CDD:214567	137/301 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0660
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D741207at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820