Protein Alignment Dlc1 and cv-c

DIOPT Version :9

• Sequence 1: NP_001357926.1
• Gene: Dlc1 / 58834
• RGDID: 68416
• Length: 1542
• Species: Rattus norvegicus
• Sequence 2: NP_001097786.1
• Gene: cv-c / 41749
• FlyBaseID: FBgn0285955
• Length: 2351
• Species: Drosophila melanogaster
• Alignment Length: 1564
• Identity: 455/1564 - (29%)
• Similarity: 698/1564 - (44%)
• Gaps: 373/1564 - (23%)

  Rat    76 RPMGHISPEVDESDSQEGEERFLSLEASTETLVHISDEDTDSDLHLINDSQI---LPP------- 130
            |.:|.:..:.:.:.|....|....:.:|.::.:.:.....|:|   .|:|.|   .||
  Fly  1058 RSVGAVDEDNNSTSSSSACEEATGVLSSGKSGISLDSSGLDND---NNESGIGTATPPKDMSHYW 1119

  Rat   131 -----QRHERDSHESVKGAGSFRKTLSTMQSSQDSHNTWTMAGEAEISAAEGGE-ERKDGDTISK 189
                 |.|....|....|            |:||:.:..::....::...:.|. ...|...:.:
  Fly  1120 KSHHLQHHHHHHHRKCTG------------SAQDNESVSSLEALRKMKFQKSGSVASSDDPDVLE 1172

  Rat   190 SLEHCKSTSASETNEVAKVNTFQSLNAKDDITPKTQLLDSLVLVKDVTPETQLLDSAVIAQQHRK 254
            .|..|  .|..|.||           ::||      :||.   .||...::|..|.
  Fly  1173 VLSQC--GSGGEANE-----------SQDD------MLDE---EKDKMSKSQDYDE--------- 1206

  Rat   255 PDFPNDDQEKNLHHVVEEDFLVAPYTDRGLPLLKADCGSCLLRPPSCPGGMSAENDLERSGFSEY 319
                                           :...||........|..||::|...:.|   .:|
  Fly  1207 -------------------------------IWDCDCTDGDASSASGGGGVTATPVILR---RKY 1237

  Rat   320 QNKSPLRVSQEGVMQCL-HVRGPVTTQETGDNQVRLRKRK------ETREDRDRTRLDSMVLLIM 377
            ....|:.|.:......| |...|         |..:..||      ...:.::|.:| |:||.
  Fly  1238 TAPPPILVPRTQRSHSLDHYHSP---------QPLVHPRKVLPIHHHALKSKERGQL-SLVLR-- 1290

  Rat   378 KLDQLDQDIENALSAASSPSSTPTNLRRHVPDLESGSESGTESITVNQTQVNLSSESTDPSSTPA 442
                     :....:..|||:|..|...|..:|.|.|.:...|        .|............
  Fly  1291 ---------QEPFQSLLSPSATAANQLHHFVELPSPSSASLHS--------GLGDSGGIQELCTK 1338

  Rat   443 SNSG---TKPKAMA---------------VPCIAEKETAEIEAKEACDWLRVTGFPQYAQLYEDL 489
            |||.   .|.:.|:               ....:::..|||||.|||.|||..|||||||:|||.
  Fly  1339 SNSAPMLLKEREMSRRFDNFEAQHLTLRYSRSQSDRYLAEIEAVEACKWLRAAGFPQYAQMYEDH 1403

  Rat   490 LFPIDIALVKREHDFLDRDAIEALCRRLNTLNKCAVMKLEIS--PHRKRSEDSDEEEPCAISGKW 552
            .||||:..|.::|..|:.|.:::|.|||..||:||.|:|:.|  |...:.::..::|..|:|..|
  Fly  1404 QFPIDLNNVAKDHTNLENDQLQSLYRRLCVLNRCATMRLDQSHKPQTPQQKEESDDENFALSEHW 1468

  Rat   553 TFQRDSKRWSRLEEFDVFSPKQDPIPGSPDNSRLQSATSRESMLTDLSEHQEVSSIRSLSSTSSS 617
            |||...:||||:.|..:    :.|.||.                  ||.:.|    ::.||:..|
  Fly  1469 TFQPHIRRWSRIGEMGL----ELPPPGL------------------LSLNVE----KTESSSKES 1507

  Rat   618 APTHVPHSGEATTPRTNSVISVCSSSHFVGNEDSFSSLPSPKELSSFSFSMKGHEKNTKSKTRSL 682
            :|......|...|    .|...||.:..:.|:.|     |..|.|......:...:..|.:.::|
  Fly  1508 SPDRFEEDGAGIT----LVTPGCSKAGGIPNDGS-----SLGEGSDSGRLRRSGSERIKDQAKAL 1563

  Rat   683 LKRMESLKLKGSHHSKHKAPSKLGLIISAPILQEGMDEEKLKQLNCVEISALNGNHINVPMVRKR 747
            |:|:||:|.:     :.|..::..::||.|
  Fly  1564 LRRVESIKSR-----RRKRQNRENVVISGP----------------------------------- 1588

  Rat   748 SVSNSTQTSSSSSQSETSSAVSTPSPVTRTRSLSTCNKRVGMYLEGFDPFSQSAFNNVTE----- 807
            :|.:.:|....||..:..:..|||...:....:.|..|.         ||    |.|..:
  Fly  1589 TVLDLSQFGQRSSLRKPDAVYSTPPSPSALSPMHTFPKA---------PF----FGNDLKVPSHS 1640

  Rat   808 QNY--KNRESYPEDTVFYIPEDHKPGTFPKALSNGSFCPSGNSSVNWRTGSFH---GPGHLSLRR 867
            .|:  .||.| |:.|          .|.|:::               ||...|   .|  :|..:
  Fly  1641 DNFLSPNRSS-PKRT----------PTTPRSM---------------RTSPLHFFSSP--MSQLK 1677

  Rat   868 ENSSDSPKELKRRNSSSSVSSRMSIYDNVPGSILYSSSGELADLENEDIFPELDDILYHVKGMQR 932
            |..||........:..||...::|:............:|            ::|||..|
  Fly  1678 EGKSDDSSSYYSDSQESSTGGKLSLRKPSKARRFLQRTG------------KVDDIGAH------ 1724

  Rat   933 IVNQWSEKFSDEGDSDSALDSVSPCPSSPKQIHLDVDHDRRTPSDLDST-GNSLNEPEEP----- 991
                                |.|.|....|.:..|.:.:.........| |.|||..::|
  Fly  1725 --------------------SDSECHQGRKLLIKDANSNTTEVKVKKLTRGGSLNLGKDPKKRDG 1769

  Rat   992 ----------TDIPE-RRDSGVGASLTRCNRHR---LRWHSFQSSHRPSL--------------- 1027
                      |...| :.|.....:.|.....|   :||||||...||::
  Fly  1770 FRSSSFRSRSTSRKEAKNDEDTAGATTNGGSKRQPVVRWHSFQMEERPNMIFRKCFSKKIEPLQE 1834

  Rat  1028 NSVSLQINCQSVAQMNLLQKYSLLKLTALLEKYTPSNKHGFSWAVPKFMKRIKVPDYKDRSVFGV 1092
            ::..:.....|..|:.:::|.:|:.||..:|:|.||::.|::|.:|||:|:||:|||||:.||||
  Fly  1835 DAGGMPFAAMSAGQLQIIRKLALVTLTGHMERYCPSHRSGWNWELPKFIKKIKMPDYKDKKVFGV 1899

  Rat  1093 PLTVNVQRSGQPLPQSIQQAMRYLRNHCLDQVGLFRKSGVKSRIQALRQMNE----SAEDYVNYE 1153
            ||.:.:|||||.||.:::.|.|:|:.:.|||||:|||||.||||..||:..|    :||....::
  Fly  1900 PLLMILQRSGQTLPLAVRAAFRWLQLNALDQVGIFRKSGGKSRIMKLREQIEVTDSTAECMDVFD 1964

  Rat  1154 GQSAYDVADMLKQYFRDLPEPLMTNKLSETFLQIYQYVPKDQRLQAIKAAIMLLPDENREVLQTL 1218
            .|.|||||||||||||:|||.|:|.|:||||:.|:|::|.:.||.|::.|::||||||||:|..|
  Fly  1965 LQQAYDVADMLKQYFRELPESLLTTKMSETFVAIFQHLPAEVRLDAVQCAVLLLPDENREILYVL 2029

  Rat  1219 LYFLSDVTAAVKENQMTPTNLAVCLAPSLFH--LNTLKRE-NSSPRVMQRKQSLGKPDQKDLNEN 1280
            |.||:.|.|..::||||..||.||||.|:||  ::|.... ::|||  ::.:..|.||.|:|.|.
  Fly  2030 LEFLTIVAANSQQNQMTSNNLGVCLAQSIFHSSISTGSASVSASPR--RKGKGSGMPDMKELAEA 2092

  Rat  1281 LAATQGLAHMIAECKKLF-QVPEEMSRCRNSYTEQELKPLTLEALGHLSNDQPADYRHFLQDCVD 1344
            .|:.:.|:.||...|::: ...|::|:|..||.| |.|||.|||||  ...|..::|.:|.:|..
  Fly  2093 KASHECLSFMIEHYKQIYTAAKEKLSKCNFSYME-ESKPLPLEALG--EGMQFHNWRGYLYECTS 2154

  Rat  1345 GLFKEVKEKFKGWVSYPT--SEQAELSYKKVSEGPPLRLWRATIEVPAAPEEILKRLLKEQHLWD 1407
            ...||.:||.:||.|..:  ....:::||||.:|.||||||.:.|:...|:|:|:.::|::..||
  Fly  2155 ATIKEGREKTRGWFSINSLNDSSVDIAYKKVGDGHPLRLWRCSTEIEGPPKEVLEFVIKQRASWD 2219

  Rat  1408 VDLLDSKVIEILDSQTEIYQYVQNSMAPHPARDYVVLRTWRTNLPRGACALLFTSVDHDRA-PVA 1471
            .:||..:.::.||.:||||||..:...   ..|:.|||:|:|:||||||.::.||:||.:| |:.
  Fly  2220 TNLLQCQTVKKLDDRTEIYQYALDGQL---TTDFCVLRSWQTDLPRGACVIVETSIDHAKAKPLF 2281

  Rat  1472 G-VRVNVLLSRYLIEPCGSGKSKLTYMCRADLRGHMPEWYTKSFGHLCAAEVVKIRDSFSN--QS 1533
            | ||..||.|||||||||||:|::.::.|.|::|..||||.|::||:|:..:.:||.:|.:  ..
  Fly  2282 GAVRGVVLASRYLIEPCGSGRSRVMHLARVDVKGKTPEWYNKNYGHICSHYLSRIRLAFKHVADG 2346

  Rat  1534 TESK 1537
            .|||
  Fly  2347 PESK 2350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dlc1	NP_001357926.1	SAM_DLC1	468..527	CDD:188990	32/58 (55%)
		RhoGAP_DLC1	1086..1304	CDD:239840	111/225 (49%)
		SRPBCC	1329..1532	CDD:417480	88/208 (42%)
cv-c	NP_001097786.1	SAM_DLC1,2-like	1382..1441	CDD:188937	32/58 (55%)
		RhoGAP_DLC1	1893..2116	CDD:239840	110/224 (49%)
		SRPBCC	2148..2343	CDD:301327	86/197 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	196	1.000	Domainoid score	I3033
eggNOG	1	0.900	-	-		E1_KOG2200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001209
OrthoInspector	1	1.000	-	-		otm44733
orthoMCL	1	0.900	-	-		OOG6_103453
Panther	1	1.100	-	-	LDO	PTHR12659
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X752
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.810