DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RAC1 and RhoBTB

DIOPT Version :9

Sequence 1:	NP_061485.1	Gene:	RAC1 / 5879	HGNCID:	9801	Length:	211	Species:	Homo sapiens
Sequence 2:	NP_001262107.1	Gene:	RhoBTB / 40249	FlyBaseID:	FBgn0036980	Length:	783	Species:	Drosophila melanogaster

Alignment Length:	236	Identity:	83/236 - (35%)
Similarity:	116/236 - (49%)	Gaps:	59/236 - (25%)

- Green bases have known domain annotations that are detailed below.

Human     2 QAIKCVVVGDGAVGKTCLLISYTTN------AFPGEYIPTVF--DNYS--ANVM------VDGKP 50
            :.:|||:|||.|||||.|:.:...|      .....::|||:  |.|.  .:|:      |||..
  Fly    12 ELVKCVLVGDTAVGKTRLICARACNKHVSLSQLLSTHVPTVWAIDQYRIYKDVLERSWEVVDGVN 76

Human    51 VNLGLWDTAGQEDYDRLRPLSYPQTVGETYGKDITSRGKDKPIADVFLICFSLVSPASFENVRAK 115
            |:|.||||.|..|.||          ...||:           :||.|:|||:.||.|..|.:..
  Fly    77 VSLRLWDTFGDHDKDR----------RFAYGR-----------SDVVLLCFSIASPISLRNCKMM 120

Human   116 WYPEVRHHCPNTPIILVGTKLDLR------------DDKDTIEK--LKEKKLTPITYPQGLAMAK 166
            ||||:|..||:.|:||||.|.|||            .:|.|..:  ||...:.|   .:..|:||
  Fly   121 WYPEIRRFCPDVPVILVGCKNDLRYMYRDENYLSYFGEKGTFVRAALKSDLVMP---DEARAVAK 182

Human   167 EIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRK 207
            |:| |.|.|.|..|..|:..||:.|||:.|    :.:|:::
  Fly   183 ELG-VAYYETSVFTYFGVNEVFENAIRSAL----IARRQQR 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAC1	NP_061485.1	Rac1_like	3..195	CDD:206663	81/221 (37%)
RhoBTB	NP_001262107.1	RhoBTB	12..210	CDD:133275	81/222 (36%)
		RHO	16..211	CDD:197554	80/219 (37%)
		BTB	<392..446	CDD:295341
		BTB	481..575	CDD:279045
		BTB	485..582	CDD:197585
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810