DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RAC1 and Rac2

DIOPT Version :9

Sequence 1:	NP_061485.1	Gene:	RAC1 / 5879	HGNCID:	9801	Length:	211	Species:	Homo sapiens
Sequence 2:	NP_001261517.1	Gene:	Rac2 / 38831	FlyBaseID:	FBgn0014011	Length:	192	Species:	Drosophila melanogaster

Alignment Length:	211	Identity:	172/211 - (81%)
Similarity:	181/211 - (85%)	Gaps:	19/211 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYD 65
            |||||||||||||||||||||||||||||||||||||||||||||||.||:||||||||||||||
  Fly     1 MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDAKPINLGLWDTAGQEDYD 65

Human    66 RLRPLSYPQTVGETYGKDITSRGKDKPIADVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPII 130
            ||||||||||                   ||||||||||:|||||||||||:||||||||:.|||
  Fly    66 RLRPLSYPQT-------------------DVFLICFSLVNPASFENVRAKWFPEVRHHCPSVPII 111

Human   131 LVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAV 195
            ||||||||||||.||||||:||||||||||||||||||.||||||||||||:|||||||||||:|
  Fly   112 LVGTKLDLRDDKQTIEKLKDKKLTPITYPQGLAMAKEIAAVKYLECSALTQKGLKTVFDEAIRSV 176

Human   196 LCPPPVKKRKRKCLLL 211
            |||.....::.||.||
  Fly   177 LCPVVRGPKRHKCALL 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAC1	NP_061485.1	Rac1_like	3..195	CDD:206663	162/191 (85%)
Rac2	NP_001261517.1	Rac1_like	3..176	CDD:206663	162/191 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1071
eggNOG	1	0.900	-	-		E2759_KOG0393
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69035
Inparanoid	1	1.050	366	1.000	Inparanoid score	I2161
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1091615at2759
OrthoFinder	1	1.000	-	-		FOG0000070
OrthoInspector	1	1.000	-	-		mtm8491
orthoMCL	1	0.900	-	-		OOG6_100633
Panther	1	1.100	-	-	O	PTHR24072
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X103
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.830