Protein Alignment RAB27B and Rab3

DIOPT Version :10

• Sequence 1: NP_004154.2
• Gene: RAB27B / 5874
• HGNCID: 9767
• Length: 218
• Species: Homo sapiens
• Sequence 2: NP_523687.1
• Gene: Rab3 / 36127
• FlyBaseID: FBgn0005586
• Length: 220
• Species: Drosophila melanogaster
• Alignment Length: 219
• Identity: 91/219 - (41%)
• Similarity: 146/219 - (66%)
• Gaps: 16/219 - (7%)

Human     3 DGDYDYLIKLLALGDSGVGKTTFLYRYTDNKFNPKFITTVGIDFREKRVVYNAQGPNGSSGKAFK 67
            |.::||:.|||.:|:|.||||:||:||.|:.|...|::||||||:.|.|..:.:          :
  Fly    15 DQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDK----------R 69

Human    68 VHLQLWDTAGQERFRSLTTAFFRDAMGFLLMFDLTSQQSFLNVRNWMSQLQANAYCENPDIVLIG 132
            |.||:||||||||:|::|||::|.||||:||:|:|::.||.:|::|::|::..:: :|..::|:|
  Fly    70 VKLQIWDTAGQERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSW-DNAQVILVG 133

Human   133 NKADLPDQREVNERQARELADKYGIPYFETSAATGQNVEKAVETLLDLIMKRMEQCVEKTQIPDT 197
            ||.|:.|||.::..:.|:|||:.|:.:|||||....||:...|.|:|:|..:|.:.::..  |..
  Fly   134 NKCDMEDQRVISFERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESLDAD--PTL 196

Human   198 VNGGNSGNLDGEKP---PEKKCIC 218
            |.||..|....::|   |...|.|
  Fly   197 VGGGQKGQRLTDQPQGTPNANCNC 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB27B	NP_004154.2	Rab27A	6..185	CDD:206700	80/178 (45%)
		Effector region. /evidence=ECO:0000250	38..46		5/7 (71%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..218		8/26 (31%)
Rab3	NP_523687.1	Rab3	21..185	CDD:206657	78/174 (45%)