DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MAP4K2 and map4k2

DIOPT Version :9

Sequence 1:	XP_024304397.1	Gene:	MAP4K2 / 5871	HGNCID:	6864	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_001035448.1	Gene:	map4k2 / 678610	ZFINID:	ZDB-GENE-030616-163	Length:	865	Species:	Danio rerio

Alignment Length:	892	Identity:	501/892 - (56%)
Similarity:	640/892 - (71%)	Gaps:	70/892 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     7 VSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRECRHP 71
            ||..||.|.:|::||:|:||||||:|||:..:||:||:|||||||||||:|:|||||:::||:|.
Zfish     6 VSFLDPLDDYEIIQRIGSGTYGDVFKARNIRSSEMAAIKIVKLDPGDDITSIQQEITMMKECKHK 70

Human    72 NVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRD 136
            |:|||.|:|.||.:||||||:|||||||:||..||||:|:||||:|||.|:||:|||..||||||
Zfish    71 NIVAYYGTYHRNTKLWICMEYCGGGSLQDIYQVTGPLKEKQIAYICRETLQGLNHLHETGKIHRD 135

Human   137 IKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALG 201
            |||||:|||.:||||||||||:.|::||||||:|||||||||||||||||:|||||.|||:||:|
Zfish   136 IKGANILLTDRGDVKLADFGVAAEISASVAKRKSFIGTPYWMAPEVAAVEKKGGYNHLCDIWAVG 200

Human   202 ITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEK 266
            ||||||.|||||:|.||||||||||||||||.|||:||::|...||.|:|:.|.|:|:||||||.
Zfish   201 ITAIELAELQPPMFDLHPMRALMLMSKSSFQSPKLKDKSKWCAGFHSFVKMCLIKSPRKRPTAET 265

Human   267 LLQHPFTTQQLPRALLTQLLDKASDPHLGTP-SPEDCELETYDMFPDTIHSRGQHGPAERTPSEI 330
            ||||||.||.|.|.|:.:|||.|::|.|..| |||:.| |..|..||.|.|:|:|...||:.||.
Zfish   266 LLQHPFVTQLLTRKLMIELLDMANNPDLHRPTSPEENE-EANDTAPDKIQSKGKHMAVERSLSEE 329

Human   331 QFHQVKFGAPRRKETDPLNEPWE-EEWTLLGKEELSGSLLQSVQEALEERSLTIRSASEFQVPHR 394
            ||.||||..||||||:|..:... ::|::.|.|..|..||:.|:|.|::||:|::..|.|:...|
Zfish   330 QFDQVKFTPPRRKETEPYPDLGSCDDWSISGDEPESPGLLECVEEELQQRSMTVKRFSFFEWSKR 394

Human   395 GRLELGSRPLQRVRLEWDVVTGQPGNGRAG-PCPSYQELDSPDDTMGTIKRAPFLGPLPTDPPAE 458
             :..|.|.|              |.:.... |..|..|.|..|..: |::.:..|.|
Zfish   395 -KSGLFSPP--------------PASATTSLPPMSSLECDLEDKDL-TLRPSATLCP-------- 435

Human   459 EPLSSPPGTL---------------PPPPSGPNS-------------SPLLPTAWATMKQREDPE 495
            |.:|:|...|               |..|.|.|:             ...|...|:||:::.:..
Zfish   436 ETVSNPKSVLLRCSGSQDVRQWCSDPCVPDGKNTEEQQRTLTRTFSRDAALSPEWSTMRKKTEDS 500

Human   496 RSSCHGLPPTPKVHMGACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHED 560
            |:..|||||||:|:|||||:||||||||:||.|.||:.|.||||:|::|||||:|.|||:|||||
Zfish   501 RADSHGLPPTPQVYMGACFTKVFNGCPLKIHCADTWVLPKTRDQYLILGAEEGVYILNLNELHED 565

Human   561 TLEKLISHRCSWLYCVNNVLLSLSGKSTHIWAHDLPGLFEQR-RLQ-QQVPLSIPTNRLTQRIIP 623
            |||||:..||:|||.:||||:|:||||:.:.:|.|..||||| .|| :|..||:.:||.|:|||.
Zfish   566 TLEKLLPQRCTWLYVMNNVLMSISGKSSQLCSHRLTALFEQRGHLQRKQGHLSLGSNRFTERIIH 630

Human   624 RRFALSTKIPDTKGCLQCRVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPA 688
            |:||:|.||||||||.:|.|.|||||.:|||.||:|:.|:||.||||||||:.||:.:.|||.|.
Zfish   631 RKFAVSVKIPDTKGCRKCSVARNPYTDSTFLCAAVPSGLVLLLWYEPLQKFMHLKHIAVPLPEPL 695

Human   689 GMLEPLVLDGKELPQVCVGA-EGPEGPG-CRVLFHVLPLEAGL---TPDILIPPEGIPGSAQQVI 748
            .:.|.|||...||||:|||. |.||... .::.|.::.|. ||   |||    .|.|  .|.||.
Zfish   696 VIFELLVLMSDELPQLCVGVQESPEQQNEPQLKFDIINLN-GLPNPTPD----SESI--RAVQVT 753

Human   749 QVDRDTILVSFERCVRIVNMQGEPTATLAPELTFDFPIETVVCLQDSVLAFWSHGMQGRSLDTNE 813
            |:||||:|::.|:.|:||||||.|:..||.:|.|||||||:|||::||||||.||::|.||...|
Zfish   754 QLDRDTVLIALEKTVKIVNMQGIPSKELASQLEFDFPIETLVCLEESVLAFWKHGLKGCSLHNCE 818

Human   814 VTQEITDETRIFRVLGAHRDIILESIPTDNPEAHSNLYILTGHQSTY 860
            .||||||::|:|:|||.||||||:|.||:||.|.|||||||||:|:|
Zfish   819 TTQEITDKSRVFKVLGTHRDIILQSTPTENPSATSNLYILTGHESSY 865

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K2	XP_024304397.1	STKc_MAP4K3_like	16..272	CDD:270788	188/255 (74%)
MAP4K2	XP_024304397.1	CNH	528..840	CDD:214481	186/318 (58%)
map4k2	NP_001035448.1	STKc_MAP4K3_like	14..272	CDD:270788	189/257 (74%)
		S_TKc	15..272	CDD:214567	189/256 (74%)
		CNH	532..845	CDD:295303	186/319 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	324	1.000	Domainoid score	I6653
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3370
Inparanoid	1	1.050	951	1.000	Inparanoid score	I2545
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG42698
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm28434
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	LDO	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	15	15.340