Protein Alignment MAP4K2 and hppy

DIOPT Version :9

• Sequence 1: XP_024304397.1
• Gene: MAP4K2 / 5871
• HGNCID: 6864
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_725863.1
• Gene: hppy / 37203
• FlyBaseID: FBgn0263395
• Length: 1218
• Species: Drosophila melanogaster
• Alignment Length: 1229
• Identity: 435/1229 - (35%)
• Similarity: 571/1229 - (46%)
• Gaps: 394/1229 - (32%)

Human     3 LLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQEITILRE 67
            |..|:|.::|:|.:||:|::|:|||||||||:...::||||:|::||:|.|||..:||||.::|:
  Fly    13 LSSDISRRNPQDEYELIQKIGSGTYGDVYKAKRIQSNELAAIKVIKLEPSDDIQIIQQEIIMMRD 77

Human    68 CRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGK 132
            |||||::||.|||||.|:||||||||||||||:||..||||.|.||||:|||.||||.:|||.||
  Fly    78 CRHPNIIAYYGSYLRRDKLWICMEFCGGGSLQDIYQVTGPLTEVQIAYMCRETLKGLEYLHSMGK 142

Human   133 IHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDV 197
            :||||||||:|||..|||||||||||.::||::.||:|||||||||||||||||||||||:|||:
  Fly   143 MHRDIKGANILLTEYGDVKLADFGVSAQITATINKRKSFIGTPYWMAPEVAAVERKGGYNQLCDI 207

Human   198 WALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRP 262
            ||.|||||||.|||||:|.|||||||.|||||.|:||.|.:|.:|:..||:|:|.||||||||||
  Fly   208 WACGITAIELAELQPPMFDLHPMRALFLMSKSGFKPPTLNNKDKWSPTFHNFIKTALTKNPKKRP 272

Human   263 TAEKLLQHPFTTQQLPRALLTQLLDKASDPH--------------LGTP---------------- 297
            |||:||||||...::...:..:||.|...|:              .|.|
  Fly   273 TAERLLQHPFVQCEMSLRVAKELLQKYQSPNPQFYYYLDGDEESVAGVPQRIASKMTSRTNGVPA 337

Human   298 --------------------SPE------------DCELETYDMFP------------------- 311
                                |||            |.||:.....|
  Fly   338 QNHTLKTGMTTNSTWNERSSSPETLPSDMSLLQYIDEELKLRATLPLNNDTKDPLGAECSCSSHN 402

Human   312 ----------------------------------DTIHSRGQHGPAERTPSEIQFHQVKFGAPRR 342
                                              .|.|...||......|:.:..|| ....|::
  Fly   403 GGAAGGGGGGGVGVGAGGAAANGSSSSSGGATVGTTHHQHQQHHQHHHHPNHLHQHQ-SHQLPQQ 466

Human   343 KETDPLNEPWEEEW----------------------------------TLLG------------- 360
            ::........:|..                                  ..||
  Fly   467 QQQQSHQAAQQEHHHHHPMTSSISSGLVTANANNISSSASLASMPGLSAYLGMRSHVVGHMGMGF 531

Human   361 -----------------KEEL-----------------------------SGSLLQSVQEALEER 379
                             .:||                             |.|....::.:...|
  Fly   532 GMGLGMSNLRTTSIDADDDELVAADVAMNNAAAAVPGNGSGAGNGSGSGCSASAAHYLRYSSNYR 596

Human   380 SLTIRSASEFQVPH----------RGRLELGS-------------RPLQRVRLEWDVVTGQPGNG 421
            |.....||:...||          .|...:.|             |.|.......|.|.|..|.|
  Fly   597 SAAAAQASQAAHPHVNSNSNSNNGHGHAPITSSISSSASSASFYNRLLLLDNSSGDAVVGGNGGG 661

Human   422 RA---------------------------------------------------------GPCPS- 428
            .:                                                         ||..|
  Fly   662 SSNISSSGGASSGTNGLLDKHELDALPQAATKSAGDGFSHSNSPTANSGAGATGSRDNDGPSSSN 726

Human   429 ----YQEL-------------------------------DSPD------------DTMGTIKRAP 446
                ||.|                               |||.            :.||...|..
  Fly   727 SSHLYQNLLRSSSGETPAGSSSAGNNCDYRHENNQNGLEDSPRRHSSMDQLIGLLENMGKSPRTR 791

Human   447 FLGPLPTDPPAEEPLSSPPGTLPPPPSGPNSSPLLPTAWATMKQREDPERSSCHGLPPTPKVHMG 511
            .|....|....|....:.|..|       |::|.:|.. .:.|:|..|.|...:|||||||||||
  Fly   792 SLSDGGTQDDDEAEKEAQPDLL-------NNTPPVPPK-RSHKRRHTPPRPISNGLPPTPKVHMG 848

Human   512 ACFSKVFNGCPLRIHAAVTWIHPVTRDQFLVVGAEEGIYTLNLHELHEDTLEKLISHRCSWLYCV 576
            |||||:|||||||:|...:||||.||||.|::|||||||.||::|||:..:::|...|.:|||.:
  Fly   849 ACFSKIFNGCPLRVHCTASWIHPETRDQHLLIGAEEGIYNLNMNELHDAAIDQLFPRRTTWLYVI 913

Human   577 NNVLLSLSGKSTHIWAHDLPGLFEQRRLQQQVPLSIPTNRLTQRIIPRRFALSTKIPDTKGCLQC 641
            .:||:||||||..::.|||..|..    :|.|..|:..|::.:|::||:|||:||:||||.|.||
  Fly   914 KDVLMSLSGKSCQLYRHDLVALHS----KQTVRFSLHMNKIPERLVPRKFALTTKVPDTKCCTQC 974

Human   642 RVVRNPYTGATFLLAALPTSLLLLQWYEPLQKFLLLKNFSSPLPSPAG------------MLEPL 694
            .|.||||.|..:|..|.|:.:.|:|||:||.||:|||....|..|..|            :.|.:
  Fly   975 CVTRNPYNGYKYLCGATPSGIFLMQWYDPLNKFMLLKQCEWPAISIQGGGHGCVQNGHTPVFEMI 1039

Human   695 VLDGKELPQVCVGAEGPEGPGCRVL----------FHVLPLE----AGLTP--DILIPPEGIPGS 743
            :....|.|.||.|...... ||..|          ||...||    |.:.|  |:|        .
  Fly  1040 ITPELEYPIVCTGVRKAMN-GCLKLELINMNSASWFHSEDLEYDAMATMVPRRDLL--------K 1095

Human   744 AQQVIQVDRDTILVSFERCVRIVNMQGEPT--ATLAPELTFDFPIETVVCLQDSVLAFWSHGMQG 806
            ..:|.||::|.|||.:...:::|.:||.|.  ..:..:|.|||.::::|||.||||||..|||||
  Fly  1096 VVRVHQVEKDAILVCYGNLIQVVTLQGNPKQHKKMVSQLNFDFNVDSIVCLPDSVLAFHKHGMQG 1160

Human   807 RSLDTNEVTQEITDETRIFRVLGAHRDIILES--IPT---DNPEAHSNLYILTGHQSTY 860
            :||...||||||.|.:|.:|:||:.:.:.|||  :.|   .:.|.| :||||.||:::|
  Fly  1161 KSLRNGEVTQEIKDMSRTYRLLGSDKVVALESQLLRTGSLGSEEGH-DLYILAGHEASY 1218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K2	XP_024304397.1	STKc_MAP4K3_like	16..272	CDD:270788	185/255 (73%)
		CNH	528..840	CDD:214481	142/343 (41%)
hppy	NP_725863.1	STKc_MAP4K3_like	25..283	CDD:270788	186/257 (72%)
		S_TKc	26..283	CDD:214567	186/256 (73%)
		CNH	869..1184	CDD:279162	137/327 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0576
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D209945at33208
OrthoFinder	1	1.000	-	-		FOG0001448
OrthoInspector	1	1.000	-	-		otm40262
orthoMCL	1	0.900	-	-		OOG6_102089
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X579
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.780