DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MAP4K2 and ppk11

DIOPT Version :9

Sequence 1:	XP_024304397.1	Gene:	MAP4K2 / 5871	HGNCID:	6864	Length:	860	Species:	Homo sapiens
Sequence 2:	NP_594517.1	Gene:	ppk11 / 2541473	PomBaseID:	SPAC2C4.14c	Length:	312	Species:	Schizosaccharomyces pombe

Alignment Length:	331	Identity:	125/331 - (37%)
Similarity:	190/331 - (57%)	Gaps:	22/331 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    13 RDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLD-PGDDISSLQQEITILRECRHPNVVAY 76
            :.::..||.:|.|::|.|::|:|..:|::.|:|:|.|| ..|.|.:|.|||..|.:....::..|
pombe     3 KHQYRDLQLIGQGSFGSVFRAQDVESSKIVALKVVDLDATKDQIETLTQEINFLIDLNSVHITKY 67

Human    77 IGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREALKGLHHLHSQGKIHRDIKGAN 141
            ..|::...||||.||:|.|||..::...:|...||.||.|.|:.|:.|.:||.|||:|||||.||
pombe    68 YASFVDGFRLWITMEYCDGGSCLDLLKLSGTFSERVIAEVMRQVLEALVYLHGQGKMHRDIKAAN 132

Human   142 LLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPEVAAVERKGGYNELCDVWALGITAIE 206
            :|....|.||||||||||:|.:...|...|:|||:||||||.   ::.|||...|:|:|||||.|
pombe   133 ILTMKDGLVKLADFGVSGQLESLRDKNDDFVGTPFWMAPEVV---KQTGYNYKADIWSLGITAYE 194

Human   207 LGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTRWTQNFHHFLKLALTKNPKKRPTAEKLLQHP 271
            |...:||...:|||:.|:|:.|.|  ||.| :::::::.|..|:...|.||||.|.|||.|.:|.
pombe   195 LATGEPPYSGIHPMKVLLLIPKHS--PPSL-ERSKFSRAFCDFVSNCLKKNPKDRATAEYLSKHK 256

Human   272 FTTQQLPRALLTQLLDKASDPHLGTPSPEDCELETYDMFPDTIHSRGQHGPAERTPSEIQFHQVK 336
            |..:..|...:.:::...:            :.:..::.|:........|.:..|..|:.:   .
pombe   257 FIKKYCPNTSVKEVVASYA------------KWKESELLPEATPYNSTMGNSANTIDEVVW---D 306

Human   337 FGAPRR 342
            ||..||
pombe   307 FGTVRR 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MAP4K2	XP_024304397.1	STKc_MAP4K3_like	16..272	CDD:270788	115/256 (45%)
MAP4K2	XP_024304397.1	CNH	528..840	CDD:214481
ppk11	NP_594517.1	STKc_MST3_like	4..278	CDD:270786	117/291 (40%)
ppk11	NP_594517.1	S_TKc	6..258	CDD:214567	115/257 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010