Protein Alignment RAB5A and VPS21

DIOPT Version :10

• Sequence 1: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Sequence 2: NP_014732.1
• Gene: VPS21 / 854256
• SGDID: S000005615
• Length: 210
• Species: Saccharomyces cerevisiae
• Alignment Length: 210
• Identity: 114/210 - (54%)
• Similarity: 144/210 - (68%)
• Gaps: 10/210 - (4%)

Human    13 NTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVCLDDTTVKFEIWDTA 77
            ||  .:...|||||||:||||||:|||||...|.|.:|.|||||||||.|.:::.||||||||||
Yeast     2 NT--SVTSIKLVLLGEAAVGKSSIVLRFVSNDFAENKEPTIGAAFLTQRVTINEHTVKFEIWDTA 64

Human    78 GQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVIALSGNKADL---AN 139
            ||||:.||||||||.||||:||||:|..:||.:|::|||||..|||.:|:|||.|||.|:   ..
Yeast    65 GQERFASLAPMYYRNAQAALVVYDVTKPQSFIKARHWVKELHEQASKDIIIALVGNKIDMLQEGG 129

Human   140 KRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKN--EPQNPGAN--SARGRGVD 200
            :|.|..:|.:..|::..|||.||||||..|||::|:.|.:|:|..  |.||..:|  .:..:.||
Yeast   130 ERKVAREEGEKLAEEKGLLFFETSAKTGENVNDVFLGIGEKIPLKTAEEQNSASNERESNNQRVD 194

Human   201 LTEPTQPT-RNQCCS 214
            |......| .|..||
Yeast   195 LNAANDGTSANSACS 209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	100/164 (61%)
		Switch 1. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	44..56		6/11 (55%)
		Switch 2. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	77..93		13/15 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		12/39 (31%)
VPS21	NP_014732.1	Rab5_related	7..172	CDD:206653	100/164 (61%)