Protein Alignment RAB5A and rab-5

DIOPT Version :10

• Sequence 1: NP_004153.2
• Gene: RAB5A / 5868
• HGNCID: 9783
• Length: 215
• Species: Homo sapiens
• Sequence 2: NP_492481.1
• Gene: rab-5 / 172755
• WormBaseID: WBGene00004268
• Length: 208
• Species: Caenorhabditis elegans
• Alignment Length: 215
• Identity: 162/215 - (75%)
• Similarity: 182/215 - (84%)
• Gaps: 10/215 - (4%)

Human     1 MASR--GATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEFQESTIGAAFLTQTVC 63
            ||:|  |..||.||   |:.|||||||||||||||||||||||||||||:|||||||||||||||
 Worm     1 MAARNAGTARPGGP---NRTCQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQTVC 62

Human    64 LDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPNIVI 128
            |||.|:|||||||||||||||||||||||||||||||||||:|||.:|||||||||||||||||:
 Worm    63 LDDATIKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQESFQKAKNWVKELQRQASPNIVM 127

Human   129 ALSGNKADLANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQNPGANS 193
            ||:|||||:||||.|:::||.:||:||:|||||||||||||||:||||||||||....|.....:
 Worm   128 ALAGNKADVANKRTVEYEEANAYAEDNALLFMETSAKTSMNVNDIFMAIAKKLPIGPAQGEPTGT 192

Human   194 ARGRGVDLTEPTQPTRNQCC 213
                 ||:.:|.|..:..||
 Worm   193 -----VDMNQPQQQQKGSCC 207

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB5A	NP_004153.2	Rab5_related	20..182	CDD:206653	143/161 (89%)
		Switch 1. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	44..56		10/11 (91%)
		Switch 2. /evidence=ECO:0000269|PubMed:20534488, ECO:0007744|PDB:3MJH	77..93		15/15 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	181..215		9/33 (27%)
rab-5	NP_492481.1	Rab5_related	19..181	CDD:206653	143/161 (89%)