Protein Alignment RAB2A and RabX6

DIOPT Version :10

• Sequence 1: NP_002856.1
• Gene: RAB2A / 5862
• HGNCID: 9763
• Length: 212
• Species: Homo sapiens
• Sequence 2: NP_001261219.1
• Gene: RabX6 / 38084
• FlyBaseID: FBgn0035155
• Length: 222
• Species: Drosophila melanogaster
• Alignment Length: 216
• Identity: 78/216 - (36%)
• Similarity: 113/216 - (52%)
• Gaps: 23/216 - (10%)

Human     8 KYIIIGDTGVGKSCLLLQFTDKRFQPVHD--LTIGVEFGARMITIDGKQIKLQIWDTAGQESFRS 70
            |.|:.||.|||||.|..:|....|....|  .|:|::...|..:::.||||||:|||.|.|...|
  Fly    10 KVILCGDYGVGKSSLFRRFATNTFITDTDRKSTLGLDHIDREYSVNEKQIKLQLWDTGGMERVAS 74

Human    71 ITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRR-EVKKEEG 134
            :|.|||:.|.||:||:.:....:|:.|:..|.|...:: .|..|.:.||||||:.|. ||..||.
  Fly    75 VTSSYYKFAEGAILVFALDNAASFHSLSQHLLDIVTYA-ENAKIFICGNKSDLDGREPEVSDEEV 138

Human   135 EAFARE-HGLI--FMETSAKTASNVEEAF---------INTAKEIYEKIQEGVFDINNEANGIKI 187
            |||..: |.||  ..:||.::.:.|||.|         .|.:|...:.::...|.::..::|
  Fly   139 EAFCEQCHSLISATYKTSCRSGAGVEEMFRDISRQLVHANRSKMELQALEHKSFQVDTASSG--- 200

Human   188 GPQHAATNATHAGNQGGQQAG 208
                ||||...|.:.|. |.|
  Fly   201 ----AATNEEDASSCGCXQLG 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	70/194 (36%)
		Required for interaction with PRKCI. /evidence=ECO:0000269|PubMed:14570876	2..19		6/10 (60%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	37..42		2/4 (50%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	63..72		3/8 (38%)
RabX6	NP_001261219.1	Rab	10..172	CDD:206640	66/162 (41%)