Protein Alignment RAB2A and Rab4

DIOPT Version :10

• Sequence 1: NP_002856.1
• Gene: RAB2A / 5862
• HGNCID: 9763
• Length: 212
• Species: Homo sapiens
• Sequence 2: NP_523777.1
• Gene: Rab4 / 36992
• FlyBaseID: FBgn0016701
• Length: 213
• Species: Drosophila melanogaster
• Alignment Length: 186
• Identity: 109/186 - (58%)
• Similarity: 135/186 - (72%)
• Gaps: 0/186 - (0%)

Human     3 YAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQES 67
            |.||||::|||..|.||||||..|.:.:|:.....|||||||:|::.:.||.:|||||||||||.
  Fly     5 YDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNVGGKSVKLQIWDTAGQER 69

Human    68 FRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKE 132
            |||:||||||||||||||||.|.||:||.||.||.|||..::.|:||:|:|||.|||..|:|...
  Fly    70 FRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASPNIVILLVGNKKDLEEARDVTFL 134

Human   133 EGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIG 188
            |...||:|:.|||:||||||..||||||:..:|.|..||:.|..|.....:||:.|
  Fly   135 EASTFAQENELIFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYG 190

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	108/184 (59%)
		Required for interaction with PRKCI. /evidence=ECO:0000269|PubMed:14570876	2..19		9/15 (60%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	37..42		3/4 (75%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	63..72		7/8 (88%)
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	98/159 (62%)