Protein Alignment RAB2A and Rab2

DIOPT Version :10

• Sequence 1: NP_002856.1
• Gene: RAB2A / 5862
• HGNCID: 9763
• Length: 212
• Species: Homo sapiens
• Sequence 2: NP_477090.1
• Gene: Rab2 / 35577
• FlyBaseID: FBgn0014009
• Length: 213
• Species: Drosophila melanogaster
• Alignment Length: 213
• Identity: 191/213 - (89%)
• Similarity: 200/213 - (93%)
• Gaps: 1/213 - (0%)

Human     1 MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQ 65
            |:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly     1 MSYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQ 65

Human    66 ESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVK 130
            |:||||||||||||||||||||||||:|||||||||||||||||||||||||||||||:||||||
  Fly    66 EAFRSITRSYYRGAAGALLVYDITRRETFNHLTTWLEDARQHSNSNMVIMLIGNKSDLDSRREVK 130

Human   131 KEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATN 195
            |||||||||||||:||||||:||:||||||||||||||||||||||||||||||||||.||:.||
  Fly   131 KEEGEAFAREHGLVFMETSARTAANVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGQQHSPTN 195

Human   196 ATHAGNQGGQ-QAGGGCC 212
            .:..|..|.. .|..|||
  Fly   196 PSLPGAGGAAGAANSGCC 213

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	179/186 (96%)
		Required for interaction with PRKCI. /evidence=ECO:0000269|PubMed:14570876	2..19		15/16 (94%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	37..42		4/4 (100%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	63..72		7/8 (88%)
Rab2	NP_477090.1	PLN03108	1..213	CDD:178655	189/211 (90%)