Protein Alignment RAB2A and Rab6

DIOPT Version :10

• Sequence 1: NP_002856.1
• Gene: RAB2A / 5862
• HGNCID: 9763
• Length: 212
• Species: Homo sapiens
• Sequence 2: NP_477172.1
• Gene: Rab6 / 34636
• FlyBaseID: FBgn0015797
• Length: 208
• Species: Drosophila melanogaster
• Alignment Length: 186
• Identity: 72/186 - (38%)
• Similarity: 115/186 - (61%)
• Gaps: 11/186 - (5%)

Human     7 FKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSI 71
            ||.:.:|:..|||:.|:.:|....|...:..|||::|.::.:.::.:.::||:|||||||.|||:
  Fly    13 FKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSL 77

Human    72 TRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEA 136
            ..||.|.:..|::|||||..::|:..:.|::|.|....|:::|||:|||:||..:|:|..||||.
  Fly    78 IPSYIRDSTVAVVVYDITNTNSFHQTSKWIDDVRTERGSDVIIMLVGNKTDLSDKRQVSTEEGER 142

Human   137 FAREHGLIFMETSAKTASNVEEAFINTAKEI----------YEKIQEGVF-DINNE 181
            .|:|..::|:|||||...||::.|...|..:          .|.:||.|. |..||
  Fly   143 KAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMDSTENKPSEDMQEVVLKDSPNE 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	72/186 (39%)
		Required for interaction with PRKCI. /evidence=ECO:0000269|PubMed:14570876	2..19		4/11 (36%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	37..42		3/4 (75%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	63..72		7/8 (88%)
Rab6	NP_477172.1	Rab6	13..173	CDD:206654	65/159 (41%)