Protein Alignment RAB2A and Rab30

DIOPT Version :10

• Sequence 1: NP_002856.1
• Gene: RAB2A / 5862
• HGNCID: 9763
• Length: 212
• Species: Homo sapiens
• Sequence 2: NP_609094.1
• Gene: Rab30 / 33988
• FlyBaseID: FBgn0031882
• Length: 223
• Species: Drosophila melanogaster
• Alignment Length: 214
• Identity: 88/214 - (41%)
• Similarity: 133/214 - (62%)
• Gaps: 8/214 - (3%)

Human     3 YAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQES 67
            |.:|||.:::|:.||||:||:.:||...|.|....||||:|..:.:.::|::||||||||||||.
  Fly     4 YKFLFKIVLVGNAGVGKTCLVRRFTQGLFPPGQGATIGVDFMIKTVEVEGEKIKLQIWDTAGQER 68

Human    68 FRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKE 132
            |||||:||||.|...:|||||:.:.||:.|..||.:.::::||.::.:|:|||:|.:. ||:..:
  Fly    69 FRSITQSYYRSAHALILVYDISCQPTFDCLPDWLREIQEYANSKVLKILVGNKTDRDD-REIPTQ 132

Human   133 EGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQE-------GVFDINNEANGIKIGPQ 190
            .||.||::|.:.|:|||||.|.|||..|...|.|:..:.:.       .......::.|..||..
  Fly   133 IGEEFAKQHDMYFLETSAKEAENVERLFYEIAAELIGQARSKDGSSSAAAAAAQRQSEGSSIGLG 197

Human   191 HAATNATHAGNQGGQQAGG 209
            ..:..|..:...||..:||
  Fly   198 SFSAKAAQSNCCGGLASGG 216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	81/191 (42%)
		Required for interaction with PRKCI. /evidence=ECO:0000269|PubMed:14570876	2..19		7/15 (47%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	37..42		3/4 (75%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	63..72		7/8 (88%)
Rab30	NP_609094.1	Rab30	1..168	CDD:133314	80/164 (49%)