Protein Alignment RAB2A and Rab27

DIOPT Version :10

• Sequence 1: NP_002856.1
• Gene: RAB2A / 5862
• HGNCID: 9763
• Length: 212
• Species: Homo sapiens
• Sequence 2: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Alignment Length: 170
• Identity: 68/170 - (40%)
• Similarity: 106/170 - (62%)
• Gaps: 5/170 - (2%)

Human     8 KYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGK----QIKLQIWDTAGQESF 68
            :::::||:||||:|||.|:||.||......|:|::|..:.:..:.:    :|.||||||||||.|
  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERF 83

Human    69 RSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNS-NMVIMLIGNKSDLESRREVKKE 132
            ||:|.::||.|.|.||::|:|...:|.....||...|.|:.| :..::|.|||.||...|.|.::
  Fly    84 RSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQLRVVSRD 148

Human   133 EGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQ 172
            :..|..|.:.|.::||||.|.:||:||.......:.|:|:
  Fly   149 QVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIE 188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	68/170 (40%)
		Required for interaction with PRKCI. /evidence=ECO:0000269|PubMed:14570876	2..19		4/10 (40%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	37..42		2/4 (50%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	63..72		7/8 (88%)
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	67/167 (40%)