Protein Alignment MPP4 and magu-1

DIOPT Version :9

• Sequence 1: NP_149055.2
• Gene: MPP4 / 58538
• HGNCID: 13680
• Length: 637
• Species: Homo sapiens
• Sequence 2: NP_497201.1
• Gene: magu-1 / 190302
• WormBaseID: WBGene00021914
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 557
• Identity: 155/557 - (27%)
• Similarity: 266/557 - (47%)
• Gaps: 103/557 - (18%)

Human   104 SPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNIPESE-EAMRIVCLVKNQQPLGAT 167
            |..:|:|.::|..|..:.:|.|...|:...|.|.||.:|..:.|.: .|::||.:|:..:|||||
 Worm    79 SSSVQQLVELLNLPRVQGVLWAAQEISAGRFAPQLPDVPFEVDEDDGVAVKIVRIVRRGEPLGAT 143

Human   168 IKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEGLDPEQVIHIL-AMSRGTIMFKV 231
            ||...  |.:.||||:..|:|:|||.:..||:::||||::|...:|.:::.:| ....|.|.||:
 Worm   144 IKCER--GKVYVARIMANGVADRSGCIQEGDRVLEVNGITVADKEPREIVKLLDKCDNGIITFKL 206

Human   232 VPVSDPPVNSQ------QMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQAR 290
            :|..   :|.:      ...|.||:.:|.|.:|...||.:|.:.|:.||||:|:|:.|..|||.|
 Worm   207 IPAE---INQKLKQKKSSHRYARALFDYDPWQDKRHPCPEAAISFRGGDILEILDEKDQYWWQTR 268

Human   291 KISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDDMK----IDEKCVEAD 351
            ||...|          |.:||:                   |...|..||.|    :..:.::..
 Worm   269 KIGFGA----------LARRKE-------------------SHDDENRDDSKKVGLVPSEWLQCQ 304

Human   352 EETFESE-ELSEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEE 415
            .|..|:. :.|:|.:.|:                    ::|                 .|..||.
 Worm   305 SEIPENGIDTSDDFQSFL--------------------ENH-----------------KGRFYES 332

Human   416 VVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVS 480
            |.|: |....:.|::||:|..|||.||:|||..:.....|.:|:|||:|.::..|.:|..|::.|
 Worm   333 VFRW-RNKKKRRRVVVLLGAPGVGRNEIRRQFFKVFADRFTNAIPHTSRPQRPNESDGVNYYFTS 396

Human   481 KETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFI 545
            :...|.:|....||||||::.:||||::.:|:....:|.: ::...|..|:.:||.|..|.|||:
 Worm   397 RSEMERMIERKEMLEYGEFRDNLYGTALKSVRKASEKGTV-LLTPHPLAIENIRTWEFAPIVIFV 460

Human   546 KPSNMRCMKQSR--------KNAKVITDYYVDMK---------FKDEDLQEMENLAQRMETQFGQ 593
            :|......|.:|        ::....:...:...         |.|.:::::.:.:.:||.::..
 Worm   461 QPPEFGEFKHTREVYRSQTTRSHSAASSSNISQNTAATSAARAFSDVEIRQIIDNSAQMEQKYRG 525

Human   594 FFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630
            :.|.:|.|..|.....:|...|.:.:.:..|:|..|:
 Worm   526 YCDAIIRNVDLDTTMNELTGLIYQLESKATWMPMKWL 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MPP4	NP_149055.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22
		L27	30..83	CDD:197794
		L27	90..140	CDD:197794	11/35 (31%)
		PDZ_signaling	153..232	CDD:238492	33/79 (42%)
		SH3_MPP4	246..306	CDD:212967	24/59 (41%)
		Guanylate_kin	428..618	CDD:331880	58/206 (28%)
magu-1	NP_497201.1	PDZ_signaling	128..201	CDD:238492	29/74 (39%)
		SH3_MPP	224..300	CDD:212796	32/104 (31%)
		Guanylate_kin	348..550	CDD:279019	56/202 (28%)
		NK	353..543	CDD:302627	52/190 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161470436
Domainoid	1	1.000	69	1.000	Domainoid score	I6850
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	282	1.000	Inparanoid score	I1987
Isobase	1	0.950	-	0	Normalized mean entropy	S2832
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D245552at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.810