DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MPP4 and mpp4a

DIOPT Version :9

Sequence 1:	NP_149055.2	Gene:	MPP4 / 58538	HGNCID:	13680	Length:	637	Species:	Homo sapiens
Sequence 2:	XP_009302812.1	Gene:	mpp4a / 100535324	ZFINID:	ZDB-GENE-070912-523	Length:	627	Species:	Danio rerio

Alignment Length:	627	Identity:	318/627 - (50%)
Similarity:	437/627 - (69%)	Gaps:	12/627 - (1%)

- Green bases have known domain annotations that are detailed below.

Human    12 DKKDMKLSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFK 76
            :::.|..|...:...||:|:|..||:|:.....||:||..||:.||.:|||.:||::|:||.:..
Zfish     6 EEESMAQSAYDDNDAGLAQVLAEVLEEVRQSIDRDINGADLLHSLLSAPWLYSLLRVYECLVQHS 70

Human    77 EKKLVPATPHAQVLSYEVVELLRETPT-SPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPP 140
            :....|..|::..||.|:...:|..|. |.:.|||..:|::||.:|||||||::||:|:.|:|||
Zfish    71 QDAPNPYLPYSTRLSQEITASVRGLPAPSSDAQELYILLKSPHMQALLSAHDSVAQRDYGPVLPP 135

Human   141 LPDNIPESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNG 205
            ||||:.::|||:||||||||:|||||||::.|.||:|.:||:||||||:|||||.:|||||||||
Zfish   136 LPDNLSDNEEAVRIVCLVKNKQPLGATIRKDEKTGNIFIARVIHGGLADRSGLLNSGDKLVEVNG 200

Human   206 VSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLPF 270
            ..|.|:.||.||:||..|:|.|:|||:|.|..|.|||..:|||||.:|.|.:||.|||.|.|:.|
Zfish   201 QKVRGMQPEHVINILVRSQGNILFKVIPNSTQPTNSQATLYVRAMVDYSPLQDPAIPCPDVGMAF 265

Human   271 QKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISM 335
            .|||:|:||||.|..||||||:...:.|.||:||.:..:.||||.|||||||.|||::...:..:
Zfish   266 SKGDLLEIVDQRDIRWWQARKLHSASLCCGLIPSTNQFRHKQRELWWSQPYQAHTCIRPLSADDV 330

Human   336 -EEEDDMKIDEKCVEADEETFE--SEELSEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHA 397
             |||...||  ||.|.|||.||  ||| .|:.|...|    .:|||||.|:|:.||||:.....:
Zfish   331 GEEEITDKI--KCTETDEEDFEFVSEE-GENGEHMQG----LYIAGFRHSLRVWRRKSYSKRKPS 388

Human   398 SVCCT-GSCYSAVGAPYEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPH 461
            ...|: .||::.....|||||.|||...|..|||||:||||||||||||:||:.||:.:|..|.:
Zfish   389 CYSCSISSCHNTSANLYEEVVHYQRHIDDPPRLIVLIGPSGVGVNELRRRLIKINPNTYQGPVSY 453

Human   462 TTRTKKSYEMNGREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLE 526
            |||.:...|.||||||:|:||.|..::.:|:..||.|:.||:||||:|:|:.||..|||||:|:|
Zfish   454 TTRPQNMGEKNGREYHFVTKEVFAYMVVNHKFYEYEEHNGHMYGTSLDSVKDVLDNGKICVIDIE 518

Human   527 PQDIQGVRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQF 591
            |..||.||...||||:|:::|.:...|:|:||:...:.:.|:...|.|:|.:::|::::.||.::
Zfish   519 PHCIQSVRNKMLKPYIIYVRPPSPEGMRQTRKDPHFLANRYIKRYFHDKDFEDIEDVSRAMEAKY 583

Human   592 GQFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWISSD 633
            .||||.||||:.|.|:|..|.:|||.|||||||:||:|.:.|
Zfish   584 RQFFDCVIVNEDLQDSCMDLFTAIQHAQEEPQWIPASWFTPD 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPP4	NP_149055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		2/9 (22%)
		L27	30..83	CDD:197794	21/52 (40%)
		L27	90..140	CDD:197794	24/50 (48%)
		PDZ_signaling	153..232	CDD:238492	54/78 (69%)
		SH3_MPP4	246..306	CDD:212967	35/59 (59%)
		Guanylate_kin	428..618	CDD:331880	95/189 (50%)
mpp4a	XP_009302812.1	L27	24..76	CDD:197794	21/51 (41%)
		L27	84..133	CDD:308467	23/48 (48%)
		PDZ	147..230	CDD:214570	56/82 (68%)
		SH3	241..300	CDD:327375	34/58 (59%)
		Guanylate_kin	419..610	CDD:331880	95/190 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194334417
Domainoid	1	1.000	180	1.000	Domainoid score	I14527
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	637	1.000	Inparanoid score	I4890
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D129022at7742
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto46401
orthoMCL	1	0.900	-	-		OOG6_116169
Panther	1	1.100	-	-	O	PTHR23122
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X7285
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	10	10.400