DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MPP4 and mpp4

DIOPT Version :9

Sequence 1:	NP_149055.2	Gene:	MPP4 / 58538	HGNCID:	13680	Length:	637	Species:	Homo sapiens
Sequence 2:	XP_031749716.1	Gene:	mpp4 / 100495166	XenbaseID:	XB-GENE-988529	Length:	684	Species:	Xenopus tropicalis

Alignment Length:	668	Identity:	407/668 - (60%)
Similarity:	514/668 - (76%)	Gaps:	49/668 - (7%)

- Green bases have known domain annotations that are detailed below.

Human    16 MKLSTATNPQNGLSQILRLVLQELSLFYGRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKL 80
            |:::.:...:|||||:|.:||:||.|:|.:||||:.:||:||.:||||:|||::.|||::.:::.
Frog    17 MEMTPSGLQENGLSQVLTMVLEELGLYYHQDVNGIGVLYNLLQAPWLQSLLKVHSCLQQYIQQRP 81

Human    81 VPATPHAQVLSYEVVELLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFEPLLPPLPDNI 145
            .|..|.|.:||.|||.:||||.:|.:::||:::||.|||||||||||.:||.||||:||||||||
Frog    82 QPVLPKACILSNEVVGVLRETTSSADLRELKRLLQGPHFKALLSAHDMVAQADFEPVLPPLPDNI 146

Human   146 PESEEAMRIVCLVKNQQPLGATIKRHEMTGDILVARIIHGGLAERSGLLYAGDKLVEVNGVSVEG 210
            |::||||||||||||:|||||||||||:||||:|||:||||||:|||||||||||||||||.|:|
Frog   147 PDNEEAMRIVCLVKNKQPLGATIKRHEITGDIIVARVIHGGLADRSGLLYAGDKLVEVNGVLVDG 211

Human   211 LDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEYWPQEDPDIPCMDAGLPFQKGDI 275
            |:|||||.|||.|.|||:||:.||:|..::|..|:|||||.:||||:||.|||.|||||||:|:|
Frog   212 LEPEQVIQILARSEGTIVFKLSPVNDRYISSHTMLYVRAMADYWPQQDPAIPCADAGLPFQRGEI 276

Human   276 LQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQREFWWSQPYQPHTCLKSTLSISMEEEDD 340
            ||||||||:|||||||.||...||||:||||||||||||||||||:..|:|:|::...::.||:|
Frog   277 LQIVDQNDSLWWQARKASDLGRCAGLIPSNHLLKRKQREFWWSQPFMSHSCIKASQLSTIGEEED 341

Human   341 MKIDEKCVEADEETFESEEL--------------------------------------------- 360
            |||:||.|||||||||||||
Frog   342 MKIEEKFVEADEETFESEELKGGNVICKFFCSVHRNSNHLVQDIYISMPQDLATIWMQPQRHNYR 406

Human   361 ----SEDKEEFVGYGQKFFIAGFRRSMRLCRRKSHLSPLHASVCCTGSCYSAVGAPYEEVVRYQR 421
                .::||:.........||||||||||||||:.::.:.....|..:||..|.|||||||||||
Frog   407 LEYFGQEKEDEFRDKDGNIIAGFRRSMRLCRRKTLINHMSCYSRCPSNCYHTVAAPYEEVVRYQR 471

Human   422 RPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMNGREYHYVSKETFEN 486
            ||.|::|||||:|||||||||:|:|||:.|||.|:|.||||||.||:||.|||||.:||||.||:
Frog   472 RPCDRHRLIVLLGPSGVGVNEMRKQLIDLNPSMFKSPVPHTTRQKKTYEENGREYFFVSKEAFES 536

Human   487 LIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQGVRTHELKPYVIFIKPSNMR 551
            ::|||..||||||.||:|||||:||:.||..|.||::|||||.|.||||||||||:|||||.:..
Frog   537 MVYSHGFLEYGEYNGHMYGTSVEAVKAVLDAGMICIIDLEPQCITGVRTHELKPYIIFIKPPSRN 601

Human   552 CMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFGQFFDHVIVNDSLHDACAQLLSAIQ 616
            ||:.:||||.:.|||||:||||:||.||:|..|::||.|||||||.|:|||:|..|..||:|.::
Frog   602 CMRYTRKNASIFTDYYVNMKFKEEDFQEIEESAKKMEVQFGQFFDQVVVNDNLESATVQLMSILR 666

Human   617 KAQEEPQWVPATWISSDT 634
            .||:||||:||:||..|:
Frog   667 CAQDEPQWIPASWICLDS 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MPP4	NP_149055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		1/5 (20%)
		L27	30..83	CDD:197794	26/52 (50%)
		L27	90..140	CDD:197794	32/49 (65%)
		PDZ_signaling	153..232	CDD:238492	66/78 (85%)
		SH3_MPP4	246..306	CDD:212967	46/59 (78%)
		Guanylate_kin	428..618	CDD:331880	127/189 (67%)
mpp4	XP_031749716.1	L27	36..84	CDD:413432	24/47 (51%)
		L27	91..139	CDD:397114	31/47 (66%)
		PDZ	153..232	CDD:214570	66/78 (85%)
		SH3_MPP4	247..307	CDD:212967	46/59 (78%)
		Guanylate_kin	478..666	CDD:395500	127/187 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H23296
Inparanoid	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120234at32523
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010