Protein Alignment EPS15L1 and Eps-15

DIOPT Version :10

• Sequence 1: NP_001425153.1
• Gene: EPS15L1 / 58513
• HGNCID: 24634
• Length: 926
• Species: Homo sapiens
• Sequence 2: NP_611965.2
• Gene: Eps-15 / 37961
• FlyBaseID: FBgn0035060
• Length: 1253
• Species: Drosophila melanogaster
• Alignment Length: 1089
• Identity: 356/1089 - (32%)
• Similarity: 500/1089 - (45%)
• Gaps: 298/1089 - (27%)

Human    18 LYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALRLVAC 82
            :||:|||.:||..||.:.|..||.|||||||||::|.:||||:||.|||||||.||:|||:||:.
  Fly    15 VYEAYYKLIDPKGTGAIEAMTAAKFLKKSGLSDVVLSRIWDLSDPSGKGFLDKPGFFVALKLVSL 79

Human    83 AQSGHEVTLSNLNLSMP-PPKFHDTSSPLMVTPPS------------AEAHWAVRVEEKAKFDGI 134
            :|:|...:::|:.|.:. |||..:    |..|.||            |...|::.|.::.|::.:
  Fly    80 SQAGQVASMANIYLDIANPPKLGE----LPKTMPSRIQTVPVASGGVANGDWSIGVIDRLKYEQL 140

Human   135 FESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMHLVYRALEKEP 199
            ||||.|.||:|.|:|||.|||:||||:.:||.:|||:|.||||:||..||.|||||||:.|:|..
  Fly   141 FESLHPSNGMLPGNKVKGVLMDSKLPMSILGTIWDLADQDKDGNLDMHEFVVAMHLVYQTLQKRT 205

Human   200 VPSALPPSLI------PPSK------------------------------RKKTVFPGAVPVLPA 228
            :||.|||.|.      ||.|                              .|....|.|:|.||.
  Fly   206 IPSVLPPELRKPGGAGPPPKPAMPPPPAGAAMPRAPSGEGFGDGGFVANFPKDIAPPAAIPPLPV 270

Human   229 SPPPKDSLRSTPSHGSVSSLNSTGSLSPKHSLKQTQPTV----------NWVVPVADKMRFDEIF 283
            :.||   :...|..|:|||          ..|.||.|.:          :|||..||..||:|||
  Fly   271 AVPP---MTRIPPVGAVSS----------QPLIQTDPLIPIGAPVMANADWVVTPADLKRFEEIF 322

Human   284 LKTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGI 348
            .::|||.||.|||.|||:||:.||:.|..||.||||.||.|:|||:.:||||||:|:::| .:|:
  Fly   323 RQSDLDKDGLVSGLEVKDIFIKSGIPQRSLADIWALCDTNQSGKLTVEQFALAMWFVERK-QRGV 386

Human   349 DPPQVLSPDMVPPSERGT-PGPDSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEE 412
            |||.||:.:|||||.|.| .|.|.........::. .||:.||:||.:|.||:..||.:|.:||.
  Fly   387 DPPHVLNANMVPPSMRATVAGVDLQPQEVKPTYSN-PELEMISKEIEELARERRVLETEIAQKEA 450

Human   413 AIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMI 477
            .:|.|..||:.||::||..|::|::||.|:.:||.|||::..|.:....:|::|........:.:
  Fly   451 DVRIKNGEVRSLQSELDTLTATLKQLENQRGEAQKRLDDLQAQVSHNTAVLANVSLDISRTNEQV 515

Human   478 SSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQ 542
            :.::.|...||..:..||.:||..:|||.:|:.||..|::...:...:|..:...|::||.:|:.
  Fly   516 TKIRDQCHMQEVTINEQEGELNAKRSELQKLKDEEASLQKEYDSNNRELSKLTNHLQATQLQISS 580

Human   543 ARSKLSQLHESRQEAHRSLEQYDQVLDGAHGASLTDLANLSEGVSLAERGSFGAMDDPFKNKALL 607
            .||.::||.|::::                   :||...:..          .||::   ..|.|
  Fly   581 VRSMVTQLLETQRQ-------------------MTDALLICR----------AAMEN---QNAEL 613

Human   608 FSNNTQELHPDPFQTEDPFKSDPFKGADPFKGDPF-QNDPFAEQQTTS---TDPFGGDPFKESDP 668
            .|....::.||    .|..:....|.....|.||| :|:..|..|.|:   :|||.|.|..:  |
  Fly   614 VSEYQLKIEPD----FDEARKTLTKEVQLPKDDPFEENNSGAANQATNGFGSDPFSGQPVNK--P 672

Human   669 FRGSATDDFFKK---------------------QTKNDPFTSDPFTKNPSLPSKLDPFESSDPFS 712
            ...:..||.|..                     ||:.|||.||.|..|.|  :.:.|....|.|
  Fly   673 AISTGFDDSFNMSSGFDSGFDAFGQSGAGSAFGQTQRDPFGSDAFAANKS--NAITPEPGKDDF- 734

Human   713 SSSVSSKGSDPFGTLD-PFGSGSFNSAEGFADFSQMSKPP------------------------- 751
                   |||||..|. |.|.|...|..     :|.|.||
  Fly   735 -------GSDPFAALHAPTGQGQVLSPN-----AQKSGPPPRPESPSPALPPKKSKVPPPRPAPP 787

Human   752 ----PSGPFTSSLGGAGFSD-DPFKSK------QDTPA------LPPKKPAP------------- 786
                |:|.|.|. ||.||:| |.|.:|      ..:|:      |||..|||
  Fly   788 RAAQPTGGFGSG-GGGGFADFDDFDNKLHHIPSAPSPSATALSPLPPTLPAPIPVVSGSSLLDSF 851

Human   787 ----------------PRPKP-------------------PSEAMAEQKNSALYSLLGG------ 810
                            |.|.|                   ||.|:|....|...|:.|.
  Fly   852 TLFDDPGQIHKQAASTPNPTPITVPTVHTLLQTSLSTPAAPSPALASLSTSGSGSVAGAGADLPS 916

Human   811 -----------------KSTPVSQLGSAD--------------FPE-----APDPFQPLGAD--S 837
                             .:||:....:||              |.|     ||.|....|..  .
  Fly   917 SVTITTAPSLNNQHLSRSNTPLQNQRTADVKLETKAVVSVFDAFGEIGTRKAPTPSLITGPTDFK 981

Human   838 GDPFQSKKGFGDPFSGKDPFVPSSAAKPSKASAS----GFADFTSFGNE 882
            .|||:..: :.||||.||||......:.|:...:    .||:..|.|:|
  Fly   982 DDPFKDYR-YEDPFSIKDPFAEEGEEELSEGKGADHKRNFAEDFSSGDE 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
EPS15L1	NP_001425153.1	Interaction with DAB2. /evidence=ECO:0000250	15..368		184/409 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..261		11/39 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..381		14/32 (44%)
Eps-15	NP_611965.2	EH	16..82	CDD:238009	42/65 (65%)
		EH	126..215	CDD:197477	50/88 (57%)
		EH	307..402	CDD:197477	57/95 (60%)
		SMC_prok_B	<423..>632	CDD:274008	69/244 (28%)