DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KMT2C and cti6

DIOPT Version :9

Sequence 1:	XP_005250082.1	Gene:	KMT2C / 58508	HGNCID:	13726	Length:	4983	Species:	Homo sapiens
Sequence 2:	NP_595212.1	Gene:	cti6 / 2539769	PomBaseID:	SPBC1685.08	Length:	424	Species:	Schizosaccharomyces pombe

Alignment Length:	424	Identity:	77/424 - (18%)
Similarity:	135/424 - (31%)	Gaps:	117/424 - (27%)

- Green bases have known domain annotations that are detailed below.

Human  1077 TQCAPCASLSSCPVCYRNYREED--LILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRP 1139
            |:|.       |.:...:....|  |.:||.||..|.|..|.....|.||..|    :.|.:|.|
pombe    49 TRCV-------CGIVESDDEASDGGLYIQCDQCSVWQHGNCVGFADESEVPEV----YYCEICHP 102

Human  1140 ----------------YM------------PASNVPSSDCCESSLVAQI---------------- 1160
                            |:            .:|:.|.|...:.|...::
pombe   103 EFHKVYQRGRGAKQSKYLGNGKPIEASQTEESSSTPPSPATKKSSKQRLTMNSRDAALDYEEYLA 167

Human  1161 VTKVKELDPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLK-IINQNSVAVLQTPPDI 1224
            :.|.|.|.|.::          .|.|..:||:...|:.:....::.|| .|.:.:..:|:...:.
pombe   168 IAKEKSLIPRRS----------RGRTSSKSLSPPAPQDESQGTEINLKQKIEEENDEILEDSKES 222

Human  1225 QSEHSRDGEMDDSREGELMDCDGKSESSPEREAVD------DETKGVEGTDGVKKRKRKPYRPGI 1283
            :.|:..:.|...:...|        ..:||.|.||      ||.|.....:..:...:...:..|
pombe   223 KDENEENKETSTTNVAE--------TDAPEEETVDTVEEIADEEKHSVKEESGEASPQSSQQSTI 279

Human  1284 GGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDGWSEQLPDTLVDESVSVTESTEKIKKR 1348
            .......||..   |.||....:|.:                .||..:..:    ...|.|:..|
pombe   280 TSISTTTRSTR---KAKREAAAEDKA----------------DLPAAVAPK----PSKTRKVGGR 321

Human  1349 YRKRKNKLEETFPAYLQEAFFGKDLL-DTSRQSKISLDNLSEDGAQLL-YKTNMNTGFLDPSLDP 1411
            ..|..:......|....:..|.:.:. .....|:|::..:....|.:| |     .|.:...:..
pombe   322 RGKSSSNDNHRIPQLHPDGTFVETITKPKGLHSRITMTEMRRRVASMLEY-----IGHIQVEMAA 381

Human  1412 LLSSSSAPTKSGTHGPADDPLADISEVLNTDDDI 1445
            ..:.:.:.|||...||.::     .|.|...|::
pombe   382 QSAGNQSSTKSSKEGPEEE-----KETLRMVDNL 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KMT2C	XP_005250082.1	ePHD1_KMT2C	248..331	CDD:277166
		PHD1_KMT2C_like	344..389	CDD:276984
		PHD2_KMT2C	391..436	CDD:277069
		PHD3_KMT2C	467..518	CDD:276986
		PHD4_KMT2C	953..1009	CDD:277071
		PHD5_KMT2C_like	1010..1056	CDD:276988
		RanBP2-type Zn finger	1085..1107	CDD:275375	5/23 (22%)
		PHD6_KMT2C	1087..1137	CDD:277073	15/51 (29%)
		HMG-box	1671..1722	CDD:294061
		DUF2962	1709..>1792	CDD:288077
		SYCE1	<3198..3287	CDD:291886
		ePHD2_KMT2C	4474..4578	CDD:277167
		FYRN	4624..4674	CDD:283589
		FYRC	4680..4761	CDD:283590
		SET	<4797..4983	CDD:225491
		SET	4844..4965	CDD:214614
		PostSET	4967..4983	CDD:214703
cti6	NP_595212.1	PHD_SF	50..100	CDD:304600	16/60 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030