DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KMT2C and Kmt2c

DIOPT Version :9

Sequence 1:	XP_005250082.1	Gene:	KMT2C / 58508	HGNCID:	13726	Length:	4983	Species:	Homo sapiens
Sequence 2:	XP_006535745.1	Gene:	Kmt2c / 231051	MGIID:	2444959	Length:	4976	Species:	Mus musculus

Alignment Length:	4998	Identity:	4257/4998 - (85%)
Similarity:	4525/4998 - (90%)	Gaps:	37/4998 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVED 65
            ||||||:|.||.||||.|||||||||||||||||||||||||||||||||||||||||||:.|||
Mouse     1 MSSEEDRSAEQQQPPPAPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKSTVED 65

Human    66 EDSMDGLETTETETIVETAEIKEQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKI 130
            |||||||||||||.|||||||||||.|||||.|||:|||.:..||||||||||||||||||||||
Mouse    66 EDSMDGLETTETENIVETAEIKEQSVEEDAETEVDSSKQPVSALQRSVSEESANSLVSVGVEAKI 130

Human   131 SEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGTYEKMQNSAPRKQRG 195
            |||||||||||||||||||||||||:|||..|||::|||| |||||||:||.||:||.|||||||
Mouse   131 SEQLCAFCYCGEKSSLGQGDLKQFRVTPGLTLPWKDQPSN-KDIDDNSSGTCEKIQNYAPRKQRG 194

Human   196 QRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWS 260
            |||||.|||:.|||||||||||.:||||||||||||||||||||:||||||||||||||||||||
Mouse   195 QRKERPPQQSAVSCVSVSTQTACEDQAGKLWDELSLVGLPDAIDVQALFDSTGTCWAHHRCVEWS 259

Human   261 LGVCQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIF 325
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
Mouse   260 LGICQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHFF 324

Human   326 LLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECK 390
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   325 LLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECK 389

Human   391 VCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWHHNCL 455
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||
Mouse   390 VCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSTQWHHNCL 454

Human   456 ICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKH 520
            |||.|||||||||||||||||||||||||||||||||||||||||||.|||:||||:||||||||
Mouse   455 ICDTCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDQELDSQLKEDYICMYCKH 519

Human   521 LGAEMDRLQPGEEVEIAELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHT 585
            ||||:|.|.||.|||:.||.|||.:.||:||.||::||.||..||||:..:..||||||||||:|
Mouse   520 LGAEIDPLHPGNEVEMPELPTDYASGMEIEGTEDEVVFLEQTVNKDVSDHQCRPGIVPDAVQVYT 584

Human   586 EEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKMSSEVKHICGEDQIEDKMEV 650
            ||.|||:|.||.||..|:.:.||.:.:|.:|..:|::|||:|..:|.|:.:|:|.|||.||:|||
Mouse   585 EEPQKSNPLESPDTVGLITSESSDNKMNPDLANEIAHEVDTEKTEMLSKGRHVCEEDQNEDRMEV 649

Human   651 TENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQ 715
            ||||||:.||..|.||.|.|.|:.|  |:.:|..|||...|  |...|.|:|||.|. ||..:|.
Mouse   650 TENIEVLPHQTIVPQEDLLLSEDSE--VASKELSPPKSAPE--TAAPEALLSPHSER-SLSCKEP 709

Human   716 LVIERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKA 780
            |:.||:|.|.|||||||.|||.:|.|||..::.|.||.|.||.|.::|.:|.||:|||:.|::||
Mouse   710 LLTERVQEEMEQKENSEFSTGCVDFEMTLAVDSCDKDSSCQGDKYVELPAEEESTFSSATDLNKA 774

Human   781 DVSSSPTPSSDLPSHDMLHNYPSALSSSAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQ 845
            |||||.|..|||||.||||.||.|.:|:||:||||||||||||||||||||||||||||||||||
Mouse   775 DVSSSSTLCSDLPSCDMLHGYPPAFNSAAGSIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQ 839

Human   846 GAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGR 910
            ||||.|||||||||:||.||||||||||||.||||||||||||||||||||||||||||||||||
Mouse   840 GAWSNHNTVSPPSWAPDTSEGREIFKPRQLSGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGR 904

Human   911 SKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRL 975
            ||||||||||||||||.||||||||:||||||||||||||||||||.||||||||||||||||||
Mouse   905 SKLKSGIGAVVLPGVSAADISSNKDEEENSMHNTVVLFSSSDKFTLQQDMCVVCGSFGQGAEGRL 969

Human   976 LACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDP 1040
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   970 LACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDP 1034

Human  1041 PLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCYRNYREEDLILQCR 1105
            |||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||
Mouse  1035 PLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCCRNYREEDLILQCR 1099

Human  1106 QCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKELDPP 1170
            |||||||||||||||||||||||||||||||||||||.|||||||||:|||||||||||||||||
Mouse  1100 QCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPVSNVPSSDCCDSSLVAQIVTKVKELDPP 1164

Human  1171 KTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMD 1235
            |||||||||||||||:||||||||.|||||:||||||||||||||||||||||||||||||||||
Mouse  1165 KTYTQDGVCLTESGMSQLQSLTVTAPRRKRTKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMD 1229

Human  1236 DSREGELMDCDGKSESSPEREAVDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTK 1300
            ||||||||||||||||||||||.||||||:||||.:|||||||||||||||||||||||||||.|
Mouse  1230 DSREGELMDCDGKSESSPEREAGDDETKGIEGTDAIKKRKRKPYRPGIGGFMVRQRSRTGQGKAK 1294

Human  1301 RSVIRKDSSGSISEQLPCRDDGWSEQLPDTLVDESVSVTESTEKIKKRYRKRKNKLEETFPAYLQ 1365
            |||:|||||||||||||.|||||.||||||||||.|||.|:|:||||||||||||||||||||||
Mouse  1295 RSVVRKDSSGSISEQLPSRDDGWREQLPDTLVDEPVSVAENTDKIKKRYRKRKNKLEETFPAYLQ 1359

Human  1366 EAFFGKDLLDTSRQSKISLDNLSEDGAQLLYKTNMNTGFLDPSLDPLLSSSSAPTKSGTHGPADD 1430
            ||||||||||||||:|:|:||||||.|||.:|    |||||||.||||||||...|.||.|.|||
Mouse  1360 EAFFGKDLLDTSRQNKLSVDNLSEDAAQLSFK----TGFLDPSSDPLLSSSSTSAKPGTQGTADD 1420

Human  1431 PLADISEVLNTDDDILGIISDDLAKSVDHSGLDLCTFQVESSPFPFDIGPVTDDPSSLPQPNVNQ 1495
            |||||||||||||||||||||||||||||||||||||||.|||||.||||.|.|.||||||.|:|
Mouse  1421 PLADISEVLNTDDDILGIISDDLAKSVDHSGLDLCTFQVGSSPFPLDIGPTTADASSLPQPGVSQ 1485

Human  1496 SSRPLSEEQLDGILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFTAVLSPANTQPTPLPQPPP 1560
            |||||:|||||||||||||||||||||||||||||||||||||||||||||||.|||.|||||||
Mouse  1486 SSRPLTEEQLDGILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFTAVLSPATTQPAPLPQPPP 1550

Human  1561 PTQLLPIHNQDAFSRMPLMNGLIGSSPHLPHNSLPPGSGLGTFSAIAQSSYPDARDKNSAFNPMA 1625
            |.||||:||||.||||||||||||.||||||||||||||||||.|||||.|.|.|||:.|||.:|
Mouse  1551 PPQLLPMHNQDVFSRMPLMNGLIGPSPHLPHNSLPPGSGLGTFPAIAQSPYTDVRDKSPAFNAIA 1615

Human  1626 SDPNNSWTSSAPTVEGENDTMSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTT 1690
            ||||:||..:.|::||||||:||||||||||||||||||||||||||||||||||||||||||||
Mouse  1616 SDPNSSWAPTTPSMEGENDTLSNAQRSTLKWEKEEALGEMATVAPVLYTNINFPNLKEEFPDWTT 1680

Human  1691 RVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSELFKD 1755
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||
Mouse  1681 RVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSNDSMKRQQQQDSIDPSSRIDSDLFKD 1745

Human  1756 PLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNE-------QQQQQQQQFGSQHLLVQ 1813
            |||||||||||||||||||||||||||||||||||||||||       ||||||||..||||||.
Mouse  1746 PLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQQQQQQQQQQQQQLASQHLLVA 1810

Human  1814 SGSDTPSSGIQSPLTPQPGNGNMSPAQSFHKELFTKQPPSTPTSTSSDDVFVKPQAPPPPPAPSR 1878
            .||||||||.|||||||.||||:||||:|||:||:|..|.||.||.||.||||||.||||..|||
Mouse  1811 PGSDTPSSGAQSPLTPQAGNGNVSPAQTFHKDLFSKHLPGTPASTPSDGVFVKPQPPPPPSTPSR 1875

Human  1879 IPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYAKMVGTPRPPPVGHSFSRRNSAAPVENC 1943
            ||:|:||||:|.|||||||:||||||:||||||:||||||||||||||.||||.||||..|||||
Mouse  1876 IPVQESLSQSQNSQPPSPQMFSPGSSHSRPPSPVDPYAKMVGTPRPPPGGHSFPRRNSVTPVENC 1940

Human  1944 TPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPYAKPPDTPRPVMTDQFPKSLGLSRSPVVS 2008
            .|||||.||:.||||:|.||||.||||:||.||:||||||||||||:|||||.|...|.||||:|
Mouse  1941 VPLSSVPRPIHMNETSATRPSPARDLCASSMTNSDPYAKPPDTPRPMMTDQFSKPFSLPRSPVIS 2005

Human  2009 EQTAKGPIAAGTSDHFTKPSPRADVFQRQRIPDSYARPLLTPAPLDSGPGPFKTPMQPPPSSQDP 2073
            ||:.|||:..||||||||||||.|.|||||:||.||.|.||||||  |.||||||:.||| ||||
Mouse  2006 EQSTKGPLTTGTSDHFTKPSPRTDAFQRQRLPDPYAGPSLTPAPL--GNGPFKTPLHPPP-SQDP 2067

Human  2074 YGSVSQASRRLSVDPYERPALTPRPIDNFSHNQSNDPYSQPPLTPHPAVNESFAHPSRAFSQPGT 2138
            ||||||.||||||||||||||||||:|||||:|||||||.||||||||:.|||.|.||||.||||
Mouse  2068 YGSVSQTSRRLSVDPYERPALTPRPVDNFSHSQSNDPYSHPPLTPHPAMTESFTHASRAFPQPGT 2132

Human  2139 ISRPTSQDPYSQPPGTPRPVVDSYSQSSGTARSNTDPYSQPPGTPRPTTVDPYSQQPQTPRPSTQ 2203
            |||..||||||||||||||::|||||:|||||||.||||||||||||.|:|||||||.|||||.|
Mouse  2133 ISRSASQDPYSQPPGTPRPLIDSYSQTSGTARSNPDPYSQPPGTPRPNTIDPYSQQPPTPRPSPQ 2197

Human  2204 TDLFVTPVTNQRHSDPYAHPPGTPRPGISVPYSQPPATPRPRISEGFTRSSMTRPVLMPNQDPFL 2268
            ||:||:.|.||||:|||.|..|.||||||||||||||.||||.||||||.|..||.|||||||||
Mouse  2198 TDMFVSSVANQRHTDPYTHHLGPPRPGISVPYSQPPAVPRPRTSEGFTRPSSARPALMPNQDPFL 2262

Human  2269 QAAQNRGPALPGPLVRPPDTCSQTPRPPGPGLSDTFSRVSPSAARDPYDQSPMTPRSQSDSFGTS 2333
            ||||||.|.|||||:||||||||||||||||..|||:..|.||.||||||.|:|||..|:|||||
Mouse  2263 QAAQNRVPGLPGPLIRPPDTCSQTPRPPGPGRIDTFTHASSSAVRDPYDQPPVTPRPHSESFGTS 2327

Human  2334 QTAHDVADQPRPGSEGSFCASSNSPMHSQGQQFSGVSQLPGPVPTSGVTDTQNTVNMAQADTEKL 2398
            |..||:.|:|.|||||:|..|||.|:.|||||||.||||||||||||.|||||||||:|||||||
Mouse  2328 QVVHDLVDRPVPGSEGNFSTSSNLPVSSQGQQFSSVSQLPGPVPTSGGTDTQNTVNMSQADTEKL 2392

Human  2399 RQRQKLREIILQQQQQKKIAGRQEKGSQDSPAVPHPGPLQHWQPENVNQAFTRPPPPYPGNIRSP 2463
            ||||||||||||||||||||.|||||.||:..||||.||.|||||::|||||||||||||:.|||
Mouse  2393 RQRQKLREIILQQQQQKKIASRQEKGPQDTAVVPHPVPLPHWQPESINQAFTRPPPPYPGSTRSP 2457

Human  2464 VAPPLGPRYAVFPKDQRGPYPPDVASMGMRPHGFRFGFPGGSHGTMPSQERFLVPPQQIQGSGVS 2528
            |.||||||||||||||||||||:||.||||||||||||||..||.||||:||.| ||||||||:.
Mouse  2458 VIPPLGPRYAVFPKDQRGPYPPEVAGMGMRPHGFRFGFPGAGHGPMPSQDRFHV-PQQIQGSGIP 2521

Human  2529 PQLRRSVSVDMPRPLNNSQMNNPVGLPQHFSPQSLPVQQHNILGQAYIELRHRAPDGRQRLPFSA 2593
            |.:||.:|::||||.||..:||||||||||.||.||||||||||||:|||||||||||.||||:|
Mouse  2522 PHIRRPMSMEMPRPSNNPPLNNPVGLPQHFPPQGLPVQQHNILGQAFIELRHRAPDGRSRLPFAA 2586

Human  2594 PPGSVVEASSNLRHGNFIPRPDFPGPRHTDPMRRPPQGLPNQLPVHPDLEQVPPSQQEQGHSVHS 2658
            .|.||:|:.|:.|||||:|||||||||||||:|:|.|.|.|||||||:|||||||||||||..|.
Mouse  2587 SPSSVIESPSHPRHGNFLPRPDFPGPRHTDPIRQPSQCLSNQLPVHPNLEQVPPSQQEQGHPAHQ 2651

Human  2659 SSMVMRTLNHPLGGEFSEAPLSTSVPSETTSDNLQITTQPSDGLEEKLDSDDPSVKELDVKDLEG 2723
            ||:|||.|||||.|||||||||||.|:||:.|||:|..|.|.|||||||||||||||||||||||
Mouse  2652 SSIVMRPLNHPLSGEFSEAPLSTSTPAETSPDNLEIAGQSSAGLEEKLDSDDPSVKELDVKDLEG 2716

Human  2724 VEVKDLDDEDLENLNLDTEDGKVVELDTLDNLETNDPNLDDLLRSGEFDIIAYTDPELDMGDKKS 2788
            ||||||||||||||||||||||..:||||||||||||||||||||||||||||||||||:|||||
Mouse  2717 VEVKDLDDEDLENLNLDTEDGKGDDLDTLDNLETNDPNLDDLLRSGEFDIIAYTDPELDLGDKKS 2781

Human  2789 MFNEELDL--PIDDKLDNQCVSVEPKKKEQENKTLVLSDKHSPQKKSTVTNEVKTEVLSPNSKVE 2851
            ||||||||  ||||||||||.|||||.::|.:||:||.||..||:||:|::|:|||.|||.||.|
Mouse  2782 MFNEELDLNVPIDDKLDNQCASVEPKTRDQGDKTMVLEDKDLPQRKSSVSSEIKTEALSPYSKEE 2846

Human  2852 SKCETEKNDENKDNVDTPCSQ-ASAHSDLNDGEKTSLHPCDPDLFEKRTNRETAGPSANVIQAST 2915
            .:.|.:.:|:::.:.||.||| |||.::.:|..||:|...|.|:.|||.|:|.|||..:.||.||
Mouse  2847 IQSEIKNHDDSRGDADTACSQAASAQTNHSDRGKTALLTTDQDMLEKRCNQENAGPVVSAIQGST 2911

Human  2916 QLPAQDVINSCGITGSTPVLSSLLANEKSDNSDIRPSGSPPPPTLPASPSNHVSSLPP-FIAPPG 2979
            .|||:||:|||.||||||||||||:|||.|:|||||||| .||:||.|||.|.||||| .|.||.
Mouse  2912 PLPARDVMNSCDITGSTPVLSSLLSNEKCDDSDIRPSGS-SPPSLPISPSTHGSSLPPTLIVPPS 2975

Human  2980 RVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIPGQSTVNHSLGTGKPATQTGPQTSQSGTSSMSG 3044
            .:|||.:|||||||.|:||.|||||.||||.|.|||:|||:||||||..||.|.|:||  |:|||
Mouse  2976 PLLDNTVNSNVTVVPRINHAFSQGVPVNPGFIQGQSSVNHNLGTGKPTNQTVPLTNQS--STMSG 3038

Human  3045 PQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAI 3109
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  3039 PQQLMIPQTLAQQNRERPLLLEEQPLLLQDLLDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAI 3103

Human  3110 TDPIMKAKMVALKGINKVMAQNNLGMPPMVMSRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITH 3174
            ||||||||||||||||||||||:|||||||||||||||..|.||||::||.|.|||:.|||||||
Mouse  3104 TDPIMKAKMVALKGINKVMAQNSLGMPPMVMSRFPFMGPSVAGTQNNDGQTLVPQAVAQDGSITH 3168

Human  3175 QISRPNPPNFGPGFVNDSQRKQYEEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKA 3239
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  3169 QISRPNPPNFGPGFVNDSQRKQYEEWLQETQQLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKA 3233

Human  3240 GREFPEEDAEQLKHVTEQQSMVQKQLEQIRKQQKEHAELIEDYRIK---QQQQCAMAPPTMMPSV 3301
            ||||||||||||||||||||||||||||||||||||||||||||||   ||||||:|||.:||.|
Mouse  3234 GREFPEEDAEQLKHVTEQQSMVQKQLEQIRKQQKEHAELIEDYRIKQQQQQQQCALAPPILMPGV 3298

Human  3302 QPQPPLIPGATPPTMSQPTFPMVPQQLQHQQHTTVISGHTSPVRMPSLPGWQPNSAPAHLPLNPP 3366
            ||||||:||||..|||||.||||||||||||||.||||||||.|||||||||.|||.||||||||
Mouse  3299 QPQPPLVPGATSLTMSQPNFPMVPQQLQHQQHTAVISGHTSPARMPSLPGWQSNSASAHLPLNPP 3363

Human  3367 RIQPPIAQLPIKTCTPAPGTVSNANPQSGPPPRVEFDDNNPFSESFQERERKERLREQQERQRIQ 3431
            |||||||||.:|||||||||||:||||:|||||||||||||||||||||||||||||||||||:|
Mouse  3364 RIQPPIAQLSLKTCTPAPGTVSSANPQNGPPPRVEFDDNNPFSESFQERERKERLREQQERQRVQ 3428

Human  3432 LMQEVDRQRALQQRMEMEQHGMVGSEISSSRTSVSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQM 3496
            ||||||||||||||||||||.::|:|: ::||.|||:|||.||.||||:||..|||||||||||:
Mouse  3429 LMQEVDRQRALQQRMEMEQHCLMGAEL-ANRTPVSQMPFYGSDRPCDFLQPPRPLQQSPQHQQQI 3492

Human  3497 GQVLQQQNIQQGSINSPSTQTFMQTNERRQVGPPSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSF 3561
            |.||||||:||||:|||..||||||||:||||||||||||||...|||||.|||.|||||.|:||
Mouse  3493 GPVLQQQNVQQGSVNSPPNQTFMQTNEQRQVGPPSFVPDSPSASGGSPNFHSVKPGHGNLPGSSF 3557

Human  3562 QQSPVRPSFTPALPAAPPVANSSLPCGQDSTITHGHSYPGSTQSLIQLYSDIIPEEKGKKKRTRK 3626
            ||||:||.|||.||...|||||::|||||..:|.|.:|.||:|||||||||||||||||||||||
Mouse  3558 QQSPLRPPFTPILPGTSPVANSNVPCGQDPAVTQGQNYSGSSQSLIQLYSDIIPEEKGKKKRTRK 3622

Human  3627 KKRDDDAESTKAPSTPHSDITAPPTPGISETTSTPAVSTPSELPQQADQESVEPVGPSTPNMAAG 3691
            ||:||||||.|||||||||..||.|||:||||||||||:|||||||..||.||||...|||::||
Mouse  3623 KKKDDDAESGKAPSTPHSDCAAPLTPGLSETTSTPAVSSPSELPQQRQQEPVEPVPVPTPNVSAG 3687

Human  3692 QLCTELENKLPNSDFSQATPNQQTYANSEVDKLSMETPAKTEEIKLEKAETESCPGQEEPKLEEQ 3756
            |.|.|.|||||||:|.:.|.||||:.|:|.||.|:|||.||||||||||||:  |.||:.|:||:
Mouse  3688 QPCIESENKLPNSEFIKETSNQQTHVNAEADKPSVETPNKTEEIKLEKAETQ--PSQEDTKVEEK 3750

Human  3757 NGSKVEGNAVACPVSSAQSPPHSAGAPAAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDC 3821
            .|:|:: :.||.||||.|.|.|..|.|..|||:|||||||||||||:||||.|||||::.|::..
Mouse  3751 TGNKIK-DIVAGPVSSIQCPSHPVGTPTTKGDTGNELLKHLLKNKKASSLLTQKPEGTLSSDESS 3814

Human  3822 TKDNKLVEKQNPAEGLQTLGAQMQGGFGCGN-QLPKTDGGSETKKQRSKRTQRTGEKAAPRSKKR 3885
            |||.||:|||:|||||||||||||||||.|| |||||||.||.||||||||||||||||||||||
Mouse  3815 TKDGKLIEKQSPAEGLQTLGAQMQGGFGGGNSQLPKTDGASENKKQRSKRTQRTGEKAAPRSKKR 3879

Human  3886 KKDEEEKQAMYSSTDTFTHLKQQLSLLPLMEPIIGVNFAHFLPYGSGQFNSGNRLLGTFGSATLE 3950
            |||||||||||||:|:||||||||||||||||||||||||||||||||||||.|||||||||.||
Mouse  3880 KKDEEEKQAMYSSSDSFTHLKQQLSLLPLMEPIIGVNFAHFLPYGSGQFNSGTRLLGTFGSAALE 3944

Human  3951 GVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLG 4015
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.:.||
Mouse  3945 GVSDYYSQLIYKQNNLSNPPTPPASLPPTPPPMACQKMANGFATTEELAGKAGVLVSHEVARALG 4009

Human  4016 PKPFQLPFRPQDDLLARALAQGPKTVDVPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPE 4080
            ||||||||||||||||||:||||||||||||||||||||.||||||||.||||||||||||||||
Mouse  4010 PKPFQLPFRPQDDLLARAIAQGPKTVDVPASLPTPPHNNHEELRIQDHYGDRDTPDSFVPSSSPE 4074

Human  4081 SVVGVEVSRYPDLSLVKEEPPEPVPSPIIPILPSTAGKSSESRRNDIKTEPGTLYFASPFGPSPN 4145
            |||||||::|||||||||||||||||||||||||.:||:|||||||||||||||:|.||||.|||
Mouse  4075 SVVGVEVNKYPDLSLVKEEPPEPVPSPIIPILPSISGKNSESRRNDIKTEPGTLFFTSPFGSSPN 4139

Human  4146 GPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEY 4210
            |||||||||||||||||||||||||||||||||||||||||||:|||||.||||||||:||.|||
Mouse  4140 GPRSGLISVAITLHPTAAENISSVVAAFSDLLHVRIPNSYEVSNAPDVPPMGLVSSHRVNPSLEY 4204

Human  4211 RQHLLLRGPPPGSANPPRLVSSYRLKQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKV 4275
            |||||||||||||||||||.:|||||||||||||||||||||||||||.||.|:|||||||||||
Mouse  4205 RQHLLLRGPPPGSANPPRLATSYRLKQPNVPFPPTSNGLSGYKDSSHGPAEGASLRPQWCCHCKV 4269

Human  4276 VILGSGVRKSFKDLTLLNKDSRESTKRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSP 4340
            ||||||||||.||||.:||.|||:|||:|||||||||||||||||.||||||:||||:|||||||
Mouse  4270 VILGSGVRKSCKDLTFVNKGSRENTKRMEKDIVFCSNNCFILYSSAAQAKNSDNKESLPSLPQSP 4334

Human  4341 MRETPSKAFHQYSNNISTLDVHCLPQLPEKASPPASPPIAFPPAFEAAQVEAKPDELKVTVKLKP 4405
            |:| ||||||||||||||||||||||..||.||||||||:||||||||:||:|||||||||||||
Mouse  4335 MKE-PSKAFHQYSNNISTLDVHCLPQFQEKVSPPASPPISFPPAFEAAKVESKPDELKVTVKLKP 4398

Human  4406 RLRAVHGGFEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVPKD 4470
            |||.|..|.||||||||||||||||||||||||||||||||||||||||||||||.|||||||||
Mouse  4399 RLRTVPVGLEDCRPLNKKWRGMKWKKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTCLKPDPVPKD 4463

Human  4471 YRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCV 4535
            .||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  4464 CRKCCFCHEEGDGLTDGPARLLNLDLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCV 4528

Human  4536 FCHKTGATSGCHRFRCTNIYHFTCAIKAQCMFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQ 4600
            |||||||||||||||||||||||||.|||||||||||||||||||||||||:|||||||||||||
Mouse  4529 FCHKTGATSGCHRFRCTNIYHFTCATKAQCMFFKDKTMLCPMHKPKGIHEQQLSYFAVFRRVYVQ 4593

Human  4601 RDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYAN 4665
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  4594 RDEVRQIASIVQRGERDHTFRVGSLIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYAN 4658

Human  4666 RRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYL 4730
            ||||||||||||||||||||||||||||||||||.|||.||||||||||||||||||||||||||
Mouse  4659 RRCRYLCSIEEKDGRPVFVIRIVEQGHEDLVLSDSSPKDVWDKILEPVACVRKKSEMLQLFPAYL 4723

Human  4731 KGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFV 4795
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  4724 KGEDLFGLTVSAVARIAESLPGVEACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFV 4788

Human  4796 LRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAA 4860
            ||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||
Mouse  4789 LRPHTLNSTSTSKSFQSTVTGELNAPYSKQFVHSKSSQYRRMKTEWKSNVYLARSRIQGLGLYAA 4853

Human  4861 RDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAP 4925
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  4854 RDIEKHTMVIEYIGTIIRNEVANRKEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAP 4918

Human  4926 NCVAEVVTFERGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN 4983
            |||||||||||||||||||:||||||||||||||||||||||||||||||||||||||
Mouse  4919 NCVAEVVTFERGHKIIISSNRRIQKGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN 4976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KMT2C	XP_005250082.1	ePHD1_KMT2C	248..331	CDD:277166	80/82 (98%)
		PHD1_KMT2C_like	344..389	CDD:276984	44/44 (100%)
		PHD2_KMT2C	391..436	CDD:277069	44/44 (100%)
		PHD3_KMT2C	467..518	CDD:276986	47/50 (94%)
		PHD4_KMT2C	953..1009	CDD:277071	54/55 (98%)
		PHD5_KMT2C_like	1010..1056	CDD:276988	45/45 (100%)
		RanBP2-type Zn finger	1085..1107	CDD:275375	20/21 (95%)
		PHD6_KMT2C	1087..1137	CDD:277073	48/49 (98%)
		HMG-box	1671..1722	CDD:294061	50/50 (100%)
		DUF2962	1709..>1792	CDD:288077	81/82 (99%)
		SYCE1	<3198..3287	CDD:291886	88/91 (97%)
		ePHD2_KMT2C	4474..4578	CDD:277167	102/103 (99%)
		FYRN	4624..4674	CDD:283589	49/49 (100%)
		FYRC	4680..4761	CDD:283590	78/80 (98%)
		SET	<4797..4983	CDD:225491	183/185 (99%)
		SET	4844..4965	CDD:214614	119/120 (99%)
		PostSET	4967..4983	CDD:214703	15/15 (100%)
Kmt2c	XP_006535745.1	PHD2_KMT2C	390..435	CDD:277069	44/44 (100%)
		PHD3_KMT2C	466..517	CDD:276986	47/50 (94%)
		PHD4_KMT2C	947..1003	CDD:277071	54/55 (98%)
		PHD5_KMT2C_like	1004..1050	CDD:276988	45/45 (100%)
		RanBP2-type Zn finger	1079..1101	CDD:275375	20/21 (95%)
		PHD6_KMT2C	1081..1131	CDD:277073	48/49 (98%)
		HMG-box	1661..1712	CDD:381793	50/50 (100%)
		Tma16	1699..>1782	CDD:371407	81/82 (99%)
		PHA03247	<1880..2370	CDD:223021	386/492 (78%)
		PHA03247	<2146..2753	CDD:223021	485/607 (80%)
		PKK	3189..3275	CDD:372134	85/85 (100%)
		Atrophin-1	3288..>3590	CDD:367360	246/302 (81%)
		ePHD2_KMT2C	4467..4571	CDD:277167	102/103 (99%)
		FYRN	4616..4667	CDD:368685	50/50 (100%)
		FYRC	4673..4757	CDD:368686	81/83 (98%)
		SET_KMT2C_2D	4823..4975	CDD:380948	149/151 (99%)
		ePHD1_KMT2C	247..330	CDD:277166	80/82 (98%)
		PHD1_KMT2C_like	343..388	CDD:276984	44/44 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83970230
Domainoid	1	1.000	5675	1.000	Domainoid score	I12
eggNOG	1	0.900	-	-		E2759_KOG4443
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H46480
Inparanoid	1	1.050	8518	1.000	Inparanoid score	I26
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG47582
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002860
OrthoInspector	1	1.000	-	-		oto117956
orthoMCL	1	0.900	-	-		OOG6_102575
Panther	1	1.100	-	-	LDO	PTHR45888
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X2220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.290