DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KMT2C and kmt2c

DIOPT Version :9

Sequence 1:	XP_005250082.1	Gene:	KMT2C / 58508	HGNCID:	13726	Length:	4983	Species:	Homo sapiens
Sequence 2:	XP_031760372.1	Gene:	kmt2c / 100486829	XenbaseID:	XB-GENE-485111	Length:	5103	Species:	Xenopus tropicalis

Alignment Length:	5299	Identity:	3149/5299 - (59%)
Similarity:	3721/5299 - (70%)	Gaps:	523/5299 - (9%)

- Green bases have known domain annotations that are detailed below.

Human     3 SEEDKSVEQPQPPPPPPEEPGAPAP-SPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDE 66
            |.||||:|.      ..|:||...| ||||.||||||||||||:||.||||||||||||.|:|||
Frog    10 SSEDKSLES------ACEQPGPQGPASPAATDKRPRGRPRKDGSSPLQRARKKPRSRGKAALEDE 68

Human    67 DSMDGLETTETETIVETAEIKEQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKIS 131
            |||||||..|.|...:| :||||..||.|.::.....||.|.||.|:.|||..|..||||:||.|
Frog    69 DSMDGLEGAEPENSADT-DIKEQPVEEGAASDAAGIAQLTPALQHSLLEESERSTASVGVQAKTS 132

Human   132 EQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDNSNGTYEKMQNSA-PRKQRG 195
            |||||||||||:|.||||:||.||.||||.|||:   ::.:..|..||.  |..:||. ..||||
Frog   133 EQLCAFCYCGERSLLGQGELKLFRPTPGFPLPWK---THSETTDTESND--ETCKNSGRTEKQRG 192

Human   196 QRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWS 260
            .||.:|| ||..:|.:.||||:||:.|||.||||..|||.|...|||||:.:|.||||.||.:||
Frog   193 PRKAKSP-QNGGACANASTQTSSDEPAGKFWDELCQVGLLDDFHIQALFEPSGHCWAHLRCAQWS 256

Human   261 LGVCQMEEPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIF 325
            .||.|.||..||:|||||:||||||||:|||||||||||||.|||.||||||||||||||.:.:.
Frog   257 PGVHQNEEQELVSVDKAVLSGSTERCAYCKHLGATIKCCEETCTQTYHYPCAAGAGTFQDLNCLT 321

Human   326 LLCPEHIDQAPERSKEDANCAVCDSPGDLLDQFFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECK 390
            ||||||||||.||||||||||:|||.||||||.|||||||||||||||||||||||||||||:||
Frog   322 LLCPEHIDQALERSKEDANCALCDSSGDLLDQLFCTTCGQHYHGMCLDIAVTPLKRAGWQCPDCK 386

Human   391 VCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSSSQWHHNCL 455
            ||||||.||:|::||||||||||||||||||||.|||||||||||||||.|||||:||.||.|||
Frog   387 VCQNCKHSGDDNQMLVCDTCDKGYHTFCLQPVMDSVPTNGWKCKNCRICTECGTRTSSLWHLNCL 451

Human   456 ICDNCYQQQDNL-CPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCK 519
            :||.|:|||.:| ||.|.|...||||||||||::||||:||:|:|.|::::|.||||:|.|..||
Frog   452 LCDPCFQQQVSLPCPICDKPLQPELQKDMLHCHVCKRWIHLDCEKCTENDIDDQLKEDYACTLCK 516

Human   520 HLGAEMDRLQPGEE---VEIAELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAV 581
            .|..|   .:||:.   :|:.|.......|||::... :..|.::|.|.:        .|.||:.
Frog   517 QLAEE---AEPGDHCVGMEVTESNNVCTGEMEMDTGR-KTTFQDKALNHN--------NIAPDST 569

Human   582 QVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSEDLKMSSEVKHICGEDQIED 646
            .|...|:                  :..|....:||...|:..|.|::    |..|.    :||:
Frog   570 TVCITEE------------------TPLHNEKAKLENDFSHSDDPEEM----ETSHA----EIEN 608

Human   647 KME--VTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESIS 709
            .|.  |.|..|...|.:..|  .:...:.|::|:..|.....|....|.||.:.......|..:.
Frog   609 PMPEGVKEKAERERHLLLPQ--SVSRHDGPKSVLPPETEASVKDKTASKTLEVSHKSPMSESKVE 671

Human   710 LCPEEQLVIERLQGEK--EQKENSEL---STGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETES 769
            .|.:.....:...|.:  .|:.|..|   :..:.:.|.|||.|...:..|....|::|..:..:|
Frog   672 SCSKMAEHFDSTGGHEGTAQENNDPLVPETPHVGEMEATPTSESLTEAGSPFVDKALKSPAGMDS 736

Human   770 SFSSSADISKADVSSSPTPSSDL-PSHDMLHNYPSALSSSAGNIMPTTYISVTPKIGMGKPAITK 833
            .. :|.|.||..|||||..|.|. ||||:..:.....|.|.||..|||:||||||||||||||||
Frog   737 PV-TSVDTSKTSVSSSPAVSIDFHPSHDLYQSQTPVTSHSTGNAFPTTFISVTPKIGMGKPAITK 800

Human   834 RKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRPR 898
            ||||||||||:|||||:||||||||||||.|||.:|.|.|||.|:..|||||||||||| |||||
Frog   801 RKFSPGRPRSRQGAWSSHNTVSPPSWSPDGSEGWDILKSRQLLGNPYWSIKVGRGSGFP-KRRPR 864

Human   899 GAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVV 963
            |:||||||||||:|||:.|...:.||::|.|:||.|::||.||||||||||.|||||||||||||
Frog   865 GSGLSGRGGRGRAKLKAPINNFIFPGITTFDVSSYKEEEETSMHNTVVLFSRSDKFTLNQDMCVV 929

Human   964 CGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDD 1028
            ||||||||||||||||||||||||||||||||||:|.||||||||||||||||||||||||||||
Frog   930 CGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVILRKGWRCLECTVCEACGKATDPGRLLLCDD 994

Human  1029 CDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYTQCAPCASLSSCPVCYR 1093
            |||||||:||||||||||||||||||||.|.:|.|.:.||||||||||||||||||||:||||.:
Frog   995 CDISYHTFCLDPPLQTVPKGGWKCKWCVSCTNCKAITPGLRCEWQNNYTQCAPCASLSACPVCCQ 1059

Human  1094 NYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVA 1158
            ||.||:||||||||.||.||.|||||||.|||..||.||||:.|:|:     |.|.:..|.::.|
Frog  1060 NYIEEELILQCRQCIRWSHASCQNLNTEAEVELAADSGFDCAACKPF-----VVSHEVIEPTIDA 1119

Human  1159 QIVTKVKELDPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPD 1223
            ||:.|.::.|..||:|||||||||||::||||||:||.|:||||||||||||||||||||||||.
Frog  1120 QIIPKTRDSDVLKTFTQDGVCLTESGLSQLQSLTITVQRKKRSKPKLKLKIINQNSVAVLQTPPY 1184

Human  1224 IQSEHSRDGEMDDSREGELMDCDGKSESSPEREAVDDETKGVEGTDGVKKRKRKPYRPGIGGFMV 1288
            .|||||||||||||||.:|||||.||:||||||.:||::|..|..||:|||||||||||||||||
Frog  1185 PQSEHSRDGEMDDSREVDLMDCDVKSDSSPEREPIDDDSKSTEVMDGLKKRKRKPYRPGIGGFMV 1249

Human  1289 RQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDGWSEQLPDTLVDESVSVTESTEKIKKRYRKRK 1353
            ||||||||||::||:.|||||||:||.||.:|:.||||||:|.:::.:..::.||||||||||:|
Frog  1250 RQRSRTGQGKSRRSLSRKDSSGSVSELLPGKDESWSEQLPETPLEDCIPGSDGTEKIKKRYRKKK 1314

Human  1354 NKLEETFPAYLQEAFFGKDLLDTSRQSKISLDNLSEDGAQLLYKTNMNTGFLDPSLDPLLSSSS- 1417
            |||||||||||||||||::|||||||||.|.:||:||.:.:||:.|:||.|||||.||:|||::
Frog  1315 NKLEETFPAYLQEAFFGRNLLDTSRQSKASTENLTEDTSHILYRANVNTSFLDPSSDPMLSSAAT 1379

Human  1418 -APTKSGTHGPADDPLADISEVLNTDDDILGIISDDL-AKSVDHSGLDLCTFQVESSPFPF---D 1477
             .|:|. :.|...|||||:||||||:|||.||::||. ...:...||||||||||:||.||   |
Frog  1380 FTPSKQ-SEGSTRDPLADLSEVLNTEDDIFGILTDDTNPTGMSTKGLDLCTFQVENSPSPFAGLD 1443

Human  1478 IGPVTDDPSSLPQPNVNQSSRPLSEEQLDGILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFT 1542
            ||.::||.|:|.|.:|.|:||||||:||||||||||||||||||||||:||||||.|||||||||
Frog  1444 IGTMSDDSSALTQSSVAQTSRPLSEDQLDGILSPELDKMVTDGAILGKMYKIPELEGKDVEDLFT 1508

Human  1543 AVLSPANTQPTPLPQPPPP--------TQLLPIHNQ--DAFSRMPLMNGLIGSSPHLPHNSLPPG 1597
            |||||..|.|..|||||||        |||||:|||  ..|.|||::|||:..:.||.||.|.||
Frog  1509 AVLSPLATHPPSLPQPPPPSAHPHPPHTQLLPLHNQGNGFFPRMPMVNGLMPPNSHLQHNPLAPG 1573

Human  1598 SGLGTFSAIAQSSYPDARDKNSAFNPMASDPNNSWTSSAPTVEGENDTMSNAQRSTLKWEKEEAL 1662
            :||||||.:|...|.::|:|...|..|.::|..||.:.|.::|.|.|||||||||||||||||||
Frog  1574 AGLGTFSPLAHPPYAESREKAPLFRSMGNEPAGSWPTQAQSLESEGDTMSNAQRSTLKWEKEEAL 1638

Human  1663 GEMATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQ 1727
            |||||||||||||:||||||:|||||.||||||||||||||||||||||||||||||||||||||
Frog  1639 GEMATVAPVLYTNVNFPNLKDEFPDWATRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQ 1703

Human  1728 MSNDSMKRQQQQDSIDPSSRIDSELFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQ 1792
            |||||:||||.:  |...|||:|:|||||||||||||||||||||||||||||||||||||||||
Frog  1704 MSNDSLKRQQHE--ILEHSRIESDLFKDPLKQRESEHEQEWKFRQQMRQKSKQQAKIEATQKLEQ 1766

Human  1793 VKNEQQQQQQQQFGSQHLLVQSGSDTPSSGIQSPLTPQPGNGNMSPA-QSFHKELFTKQP-PSTP 1855
            ||:|||||||||||||..|.|||||||:||||||||||||:.||||. |.|:|::|:||| |.||
Frog  1767 VKSEQQQQQQQQFGSQQHLSQSGSDTPNSGIQSPLTPQPGSENMSPVQQGFNKDIFSKQPMPGTP 1831

Human  1856 TSTSSDDVFVKPQAPPPPPAPSRIPIQDSLSQAQTSQPPSPQVFSPGSSNSRPPSPMDPYAKMVG 1920
            || .|||||:||||  |||.|:|||:|||...:|:|||||||:||||||||||.||:||||||||
Frog  1832 TS-FSDDVFLKPQA--PPPTPTRIPLQDSYQFSQSSQPPSPQMFSPGSSNSRPTSPVDPYAKMVG 1893

Human  1921 TPRPPPVGHSFSRRNSAAPVENCTPLSSVSRPLQMNETTANRPSPVRDLCSSSTTNNDPYAKPPD 1985
            ||||||.|.:|.||||.:||:.|.  |..|...:||:   ||||||||.| ||...:||..|.|.
Frog  1894 TPRPPPTGQTFHRRNSRSPVDVCP--SRTSSGCEMND---NRPSPVRDSC-SSPVGSDPSLKIPH 1952

Human  1986 TPRPVM-TDQFPKSLGLSRSPVVSEQTAKGPIAAGTSDHFTKPSPRADVFQRQ-----RIPDSYA 2044
            :.|.:| ::...|..|:.|.||.::|..:|.:..|::|.|.:...|:||||||     ::.|.|.
Frog  1953 SQRSLMSSESLSKLTGVGRLPVNADQALEGSLMLGSNDSFARLPSRSDVFQRQQMAHSKVVDQYK 2017

Human  2045 RPLLTPAP--LDSGPGPFKTPMQPPPSSQDPYGSVSQASRRLSVDPYERPALTPRPIDNFSHNQS 2107
            ||.|.|.|  .|....||||||:||.|.|:.|| :|..|||||.||||||.|||||.:||||
Frog  2018 RPPLAPTPGIADGSSAPFKTPMRPPQSPQESYG-LSITSRRLSADPYERPPLTPRPAENFSH--- 2078

Human  2108 NDPYSQPPLTPHPAVNESFAHPSRA---------------------------------------- 2132
             |||||..|:.|||:||.|.||.|.
Frog  2079 -DPYSQSALSSHPALNEPFVHPHRVVRLHNDTISRTNTQDPYAQQPGTPRPVSNPFLQSPRSAVI 2142

Human  2133 ---------------------------------------------FS-------------QPGTI 2139
                                                         ||             ||||
Frog  2143 DHYIQQPSRPPVQPADPYSQPPGTPRPNMGDMFVPPTMSKRHHDPFSPGNSRQVVDPYSQQPGT- 2206

Human  2140 SRPTSQDPYSQPPGTPRPV---------------------------------------------- 2158
            .||.|.|||||||||||||
Frog  2207 PRPVSVDPYSQPPGTPRPVPSDPYAKPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVP 2271

Human  2159 ------------------------------VDSYSQSSGTARS-NTDPYSQPPGTPRPTTVDPYS 2192
                                          .|.|||..||.|. .:||||||||||||...||||
Frog  2272 SDPYSQPPGTPRPIPSDPYSQPPGTPRPIPSDPYSQPPGTPRPIPSDPYSQPPGTPRPVPSDPYS 2336

Human  2193 QQPQTPRP--------------STQTDLFVTPVTNQR--HSDPYAHPPGTPRPGISVPYSQPPAT 2241
            |.|.||||              ...:|.:..|....|  .||||:.|||||||..|.||||||.|
Frog  2337 QPPGTPRPVPSDPYSQPPGTPRPVPSDPYSQPPGTPRPVTSDPYSQPPGTPRPVASDPYSQPPGT 2401

Human  2242 PRPRISEGFTRSSMT-RPV---------------------------LMPNQDPFLQAAQNRGPAL 2278
            |||.:|:.:::...| |||                           |:|||:.|.|.|..|||::
Frog  2402 PRPVLSDPYSQPPRTPRPVLCDPYAQPPRTPMPGILENCSPAIRGGLLPNQEHFRQTAHLRGPSM 2466

Human  2279 PGPLVRPPDTCSQTPRPPGPGLSDTFSRVSPSAARDPYDQSPMTPRSQS-DSFGTSQTAHDVADQ 2342
            ..|.|||.|   |.|||.|||.||.|...|...:.|||||.|||||.|: |.||   .|.:|.|.
Frog  2467 LVPFVRPSD---QNPRPAGPGPSDMFGHSSAGLSHDPYDQPPMTPRMQAVDGFG---DATEVVDP 2525

Human  2343 PRPGSEGSFCASSNSPMHSQGQQFSGVSQLPGPVPTSGVTDTQNTVNMAQADT-EKLRQRQKLRE 2406
            .||..|.:|.|.:....:.|.|.|..:.|     ..:.::|.||::.:.||:: |||||||||||
Frog  2526 QRPIIEEAFVAPAGINANPQVQPFPSMQQ-----GLAVISDAQNSLTLTQAESEEKLRQRQKLRE 2585

Human  2407 IILQQQQQKKIAGRQEKGSQDSPAVPHPGPLQHWQPEN----VNQAFTRPPPPYPGNIRSPVAPP 2467
            :||:|||.|. :.||||...|...:|..|...||||||    .::.|.||||||||:||....|.
Frog  2586 LILRQQQSKH-SVRQEKALLDPLQIPQGGHPTHWQPENPPPVQSEVFNRPPPPYPGSIRVSFGPK 2649

Human  2468 LGPRYAVFPKDQRGPYP-----------PDVASMGMR-PHGFRFGFPGGSHGTMPSQERFLVPPQ 2520
            ..||:.|||||||||:|           .|::||.|| |.|.|..:|....|::...|||:..|.
Frog  2650 GSPRFPVFPKDQRGPFPGNGQFNRPPFSGDMSSMRMRPPQGNRMAYPMVGPGSVLGHERFVGNPL 2714

Human  2521 QIQGSGVSPQLRRSVSVDMPRPLNNSQMNNPVGLPQHFSPQSLPVQQHNILGQAYIELRHRAPDG 2585
            |:|.:|:.||:||.:|:::.||:.::||:|.||||.||..|.:  |||:|.||||||||||.|||
Frog  2715 QMQMTGMQPQMRRDMSIELTRPVGSTQMSNSVGLPLHFPHQGM--QQHSISGQAYIELRHRPPDG 2777

Human  2586 RQRLPFSAPPGSVVEASSNLRHGNFIPRPDFPGPRHTDPMRRPPQGLPNQLPVHPDLEQVPPSQQ 2650
            |.|:.| ||| ::::.|.|:|||.|.||.|..|.|..||.|.|...|||.:.:.|||:|:.|: .
Frog  2778 RPRILF-APP-NLMDGSQNIRHGGFFPRSDCHGQRLMDPSRVPHPDLPNPMQIPPDLDQLIPA-T 2839

Human  2651 EQGH---SVHSSSMVMRTLNHPLGGEFSEAPLSTSVP---SETTSDNLQITTQPSDGLEEKLDSD 2709
            .|||   |.|...:||..:..|.|   :|..|.:|:|   |...:|||.|..|.:.|||.|||.|
Frog  2840 PQGHLLPSDHQPVLVMGGMEPPSG---TETFLQSSLPPMNSHEEADNLPIDGQTNSGLEVKLDPD 2901

Human  2710 DPSVKELDVKDLEGVEVKDLDDEDLENLNLDTEDGKVVELDTLDNLETNDPNLDDLLRSGEFDII 2774
            |||||:||||||.|||||||||:||:|:|||  |.|..|||.|||||||||.|||||:||:||||
Frog  2902 DPSVKDLDVKDLVGVEVKDLDDDDLDNINLD--DAKGDELDALDNLETNDPQLDDLLKSGKFDII 2964

Human  2775 AYTDPELDMGDKKSMFNEELDL--PIDDKLDNQCVSVEPKKKEQENKTLVLSDKHSPQKKST--- 2834
            ||||||||:||||.:|||:|||  |||||||      .|.|.:.     :.:::|..|..||
Frog  2965 AYTDPELDLGDKKDLFNEDLDLGVPIDDKLD------LPSKSDD-----ITTEQHGSQATSTTLL 3018

Human  2835 -------VTNEVKTEVLSPNS----KVESKCE------TEKNDENKDNVDTPCSQASAHSDLNDG 2882
                   |:.|.|.:::|.||    .||.|.|      |:::|||..:|..
Frog  3019 SVPQASGVSLESKGDLMSSNSSDRPSVEVKSELGVEARTQQHDENSASVPL-------------- 3069

Human  2883 EKTSLHPCDPDLFEKRTNRETAGPSANVIQASTQLPAQDVINSCGITGSTPVLSSLLANEKSDNS 2947
                   |..:...||  .:.|.|||::.:.:..||.||:.:|..:..|||||:.||:::||.|:
Frog  3070 -------CSTECSVKR--EKEAHPSAHISEDAIALPEQDIGSSGNLPESTPVLAGLLSSDKSGNA 3125

Human  2948 DIRPSGSPPPPTLPASPSNHVSSLPPFIAPPGRVLDNAMNSNVTVVSRVNHVFSQGVQVNPGLIP 3012
            ::......|...:...|     .:|..:....::::.|:|.::|  .|:||.|.||   :|...|
Frog  3126 EVESLDCAPGAVVATEP-----CIPQDVRTSEQLMEQALNPSMT--PRLNHGFPQG---SPSKSP 3180

Human  3013 GQSTV--NHSLGTGKPATQTGPQTSQSGTSSMSGPQQLMIPQTLAQQNRERPLLLEEQPLLLQDL 3075
            ..|.:  .|:..:|:..:||.|..:|...:.:...||||:     ||:|||||||||||||||||
Frog  3181 FVSALPSGHNFVSGENPSQTIPLPNQPCAAGLPSAQQLML-----QQSRERPLLLEEQPLLLQDL 3240

Human  3076 LDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGMPPMVM 3140
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||:||||:
Frog  3241 LDQERQEQQQQRQMQAMIRQRSEPFFPNIDFDAITDPIMKAKMVALKGINKVMAQNNLGIPPMVI 3305

Human  3141 SRFPFMGQVVTGTQNSEGQNLGPQAIPQDGSITHQISRPNPPNFGPGFVNDSQRKQYEEWLQETQ 3205
            :|||||.|.::..|..:.|::..|||.||||:..|::|||||:||||||||||:|:||:||||||
Frog  3306 NRFPFMAQQMSSAQAPDSQSIVQQAITQDGSLAPQMTRPNPPSFGPGFVNDSQKKKYEDWLQETQ 3370

Human  3206 QLLQMQQKYLEEQIGAHRKSKKALSAKQRTAKKAGREFPEEDAEQLKHVTEQQSMVQKQLEQIRK 3270
            ||||:|||:||||||||||||||||||||.|||.|||||||||||||.|||||||||||||||||
Frog  3371 QLLQIQQKFLEEQIGAHRKSKKALSAKQRAAKKTGREFPEEDAEQLKQVTEQQSMVQKQLEQIRK 3435

Human  3271 QQKEHAELIEDYRIKQQQQCAMAPPTMMPSVQPQPPLIPGATPPTMSQPTFPMVPQQLQHQQHTT 3335
            |||||.||||:||.||.||.::.|  |:|..|.|.|::||..|.:::...||:.  |..|.| ..
Frog  3436 QQKEHTELIEEYRTKQHQQFSITP--MIPGGQHQQPVMPGGAPTSVNPQNFPLA--QTLHPQ-AP 3495

Human  3336 VISGHTSPVRMPSLPGWQ-PNSAPAHLPLNPPRIQPPIAQLPIKTCTPAPGTVSNANPQSGPPPR 3399
            ||.|..:|.||||||||| ||:..|.:..|.||.|           .|....|:|:||.:  |||
Frog  3496 VILGQANPSRMPSLPGWQAPNAPRALVQPNAPRAQ-----------RPTNADVANSNPNA--PPR 3547

Human  3400 VEFDDNNPFSESFQERERKERLREQQERQRIQLMQEVDRQRALQQRMEMEQHGMVGSEISSSRTS 3464
            |||||||||||:|||||||||||||||||||||||||||||.||||:|||||||:|.::::.  |
Frog  3548 VEFDDNNPFSETFQERERKERLREQQERQRIQLMQEVDRQRVLQQRLEMEQHGMIGPDLNNG--S 3610

Human  3465 VSQIPFYSSDLPCDFMQPLGPLQQSPQHQQQMGQVLQQQNIQQGSINSPSTQTFMQTNERRQVGP 3529
            :||:||:||:||.||||...|.||.||....|    .|||:|||.:|||....|:||.||..:|.
Frog  3611 LSQMPFFSSELPSDFMQLPQPSQQPPQASHTM----PQQNLQQGLVNSPPAANFIQTAERSPMGL 3671

Human  3530 PSFVPDSPSIPVGSPNFSSVKQGHGNLSGTSFQQSPVRPSFTPALPAAPPVANSSLPCGQDSTIT 3594
            ..|       ..|:....||:|..|::..|..    .:|.|..::|:|.|.|::.....||::.|
Frog  3672 SPF-------GQGAQPVQSVQQSPGSILSTGH----AKPPFASSVPSASPAADNGHSSEQDNSNT 3725

Human  3595 HGHSYPGSTQSLIQLYSDIIPEEKGKKKRTRKKKRDDDAESTKAPSTPHSDITAPPTPGISETTS 3659
            ..|..|  :||||||||.|||||||||||.||||:||:.||.|:||||.||:|||.||.:|| .|
Frog  3726 SSHQAP--SQSLIQLYSAIIPEEKGKKKRQRKKKKDDETESVKSPSTPRSDMTAPLTPSLSE-AS 3787

Human  3660 TPAVSTPSELPQQADQESVEPVGPSTPNMAAGQLCTELENKLPNSDFSQ---ATPNQQTYANSEV 3721
            ||.|:.|::|..||:..: :.:..||||: .|....|||:.|..:|..|   ..||.:..|..:
Frog  3788 TPTVTAPNDLAYQAEHPN-DFIRSSTPNV-TGNTAVELEDPLVPADVKQRLFQEPNPERTAAGQ- 3849

Human  3722 DKLSMETPA-KTEEIKLEKAETESC--PGQEEPKLEEQNGSKVEGNAVACPVSSAQSPPHSAGAP 3783
               ...|.| |.:.||||:|:.:..  ..|||.|:||...:  ..||::..::|     ..|..|
Frog  3850 ---HHTTEALKIQNIKLERADEDQAVEAAQEEGKMEENKAT--SHNALSMDITS-----QPASGP 3904

Human  3784 AAKGDSGNELLKHLLKNKKSSSLLNQKPEGSICSEDDCTKDNKLVEKQNPAEGLQTLGAQMQGGF 3848
            :.|.:||||||||||||||...:|:||.|.|:.||:.|..:.|:.|.|.....||....:..|.|
Frog  3905 SGKLESGNELLKHLLKNKKDPFMLHQKSEESLRSEEHCPLNVKVPEMQGHLNSLQMPENKEPGCF 3969

Human  3849 GCGNQL-PKTDGGSETKKQRSKRTQRTGEKAAPRSKKRKKDEEEKQAMYSSTDTFTHLKQQLSLL 3912
            .....| .|::...|.||.|:||.||:..||.|||||||||||:|.|:|::.:|||.:|||||||
Frog  3970 NLNQSLFQKSEFEMEKKKPRNKRVQRSEGKATPRSKKRKKDEEQKSAIYANAETFTQIKQQLSLL 4034

Human  3913 PLMEPIIGVNFAHFLPYGSGQFNSGNRLLGTFGSATLEGVSDYYSQLIYKQNNLSNPPTPPASLP 3977
            ||:|||:|:|.|.|||||:|...:|:||.||||||:||||||||||||:||||||||||||||||
Frog  4035 PLIEPIVGMNIAQFLPYGAGSVCTGSRLHGTFGSASLEGVSDYYSQLIFKQNNLSNPPTPPASLP 4099

Human  3978 PTPPPMACQKMANGFATTEELAGKAGVLVSHEVTKTLGPKPFQLPFRPQDDLLARALAQGPKTVD 4042
            |||||::|||:.|||||||||||||.:|..| |||.||||.||||||.||||:|||:.||||:||
Frog  4100 PTPPPVSCQKLVNGFATTEELAGKAAILGGH-VTKALGPKQFQLPFRTQDDLIARAMTQGPKSVD 4163

Human  4043 VPASLPTPPHNNQEELRIQDHCGDRDTPDSFVPSSSPESVVGVEVSRYPDLSLVKEEPPEPVPSP 4107
            |||||||||||||||||.||||..||:|||||||||||||||:|:.|||||||||||||:|..||
Frog  4164 VPASLPTPPHNNQEELRAQDHCDSRDSPDSFVPSSSPESVVGIEIRRYPDLSLVKEEPPDPAQSP 4228

Human  4108 IIPILPSTAGKSSESRRNDIKTE--PGTLYFASPFGPSPNGPRSGLISVAITLHPTAAENISSVV 4170
            |||||||:.||.|..|....|||  |||::|...|..:|:||::||||||||||||||||||.||
Frog  4229 IIPILPSSMGKGSVLRDCAFKTEPPPGTMFFGPQFVQAPSGPKTGLISVAITLHPTAAENISGVV 4293

Human  4171 AAFSDLLHVRIPNSYEVSSAPDVPSMGLVSSHRINPGLEYRQHLLLRGPPPGSANPPRLVSSYRL 4235
            |||:|||.|:||.|||||:|.:..|:.|::.||:||.::|||....:.|.||...|.||:..|.|
Frog  4294 AAFADLLQVQIPTSYEVSNAREPGSVILMNGHRLNPNMDYRQQFFRQRPRPGPLPPGRLIGPYGL 4358

Human  4236 KQPNVPFPPTSNGLSGYKDSSHGIAESAALRPQWCCHCKVVILGSGVRKSFKDLTLLNKDSREST 4300
            :..|:||..:.|   |::.::..|..|..|:|.||||||||:||.|||||.|||:...::...|.
Frog  4359 RPQNLPFLSSDN---GFRHNNSNIESSPVLKPSWCCHCKVVVLGCGVRKSMKDLSFFKQECLRSP 4420

Human  4301 KRVEKDIVFCSNNCFILYSSTAQAKNSENKESIPSLPQSPMRETPSKAFHQYSNNISTLDVHCLP 4365
            .|::.::||||||||:|||: ||:|:.|.|...||.....::|...|:.|||:.|.|||||||||
Frog  4421 GRMDGNLVFCSNNCFLLYSA-AQSKHLEAKRPDPSFLPPSVKEAQPKSCHQYNTNTSTLDVHCLP 4484

Human  4366 QLPEKASPPASPPIAFPP-AFEAAQVEAKPDELKVTVKLKPRLRAVHGGFEDCRPLNKKWRGMKW 4429
            .|.||:|||.||||:||| ||:.|:|||||||||||||||||.||||||::||||.:||||||||
Frog  4485 LLQEKSSPPTSPPISFPPAAFQTAKVEAKPDELKVTVKLKPRPRAVHGGYDDCRPASKKWRGMKW 4549

Human  4430 KKWSIHIVIPKGTFKPPCEDEIDEFLKKLGTSLKPDPVPKDYRKCCFCHEEGDGLTDGPARLLNL 4494
            ||||:.|||||..|||.||:|:.|..::|||||||.|:.|||||||||||||||||||.||||||
Frog  4550 KKWSVQIVIPKMPFKPQCENELAEMFRRLGTSLKPHPLCKDYRKCCFCHEEGDGLTDGSARLLNL 4614

Human  4495 DLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCVFCHKTGATSGCHRFRCTNIYHFTC 4559
            ||||||||||||||||||||||||||||||||||||||||.|||||||||.|||.||||||||||
Frog  4615 DLDLWVHLNCALWSTEVYETQAGALINVELALRRGLQMKCGFCHKTGATSSCHRLRCTNIYHFTC 4679

Human  4560 AIKAQCMFFKDKTMLCPMHKPKGIHEQELSYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGS 4624
            ||||||||||||||||.||||||:|||||:|||||||||||||||||||||||||||||||||||
Frog  4680 AIKAQCMFFKDKTMLCTMHKPKGLHEQELTYFAVFRRVYVQRDEVRQIASIVQRGERDHTFRVGS 4744

Human  4625 LIFHTIGQLLPQQMQAFHSPKALFPVGYEASRLYWSTRYANRRCRYLCSIEEKDGRPVFVIRIVE 4689
            ||||.||||||||||.|||..||||||:||||||||.|||||||||||||||.||.|:||:|::|
Frog  4745 LIFHAIGQLLPQQMQNFHSATALFPVGFEASRLYWSMRYANRRCRYLCSIEENDGLPLFVVRVIE 4809

Human  4690 QGHEDLVLSDISPKGVWDKILEPVACVRKKSEMLQLFPAYLKGEDLFGLTVSAVARIAESLPGVE 4754
            .|||:|||.|.|.||||||||||||..||.||:|:|||.:||||||:|||.|||.||||||||||
Frog  4810 PGHEELVLMDSSLKGVWDKILEPVANCRKGSEILRLFPVFLKGEDLYGLTASAVTRIAESLPGVE 4874

Human  4755 ACENYTFRYGRNPLMELPLAVNPTGCARSEPKMSAHVKRFVLRPHTLNSTSTSKSFQSTVTGELN 4819
            ||||||||||||||||||||:||:|.|||||||::||||||||||||||||||||||||||||||
Frog  4875 ACENYTFRYGRNPLMELPLAINPSGSARSEPKMNSHVKRFVLRPHTLNSTSTSKSFQSTVTGELN 4939

Human  4820 APYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANR 4884
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog  4940 APYSKQFVHSKSSQYRKMKTEWKSNVYLARSRIQGLGLYAARDIEKHTMVIEYIGTIIRNEVANR 5004

Human  4885 KEKLYESQNRGVYMFRMDNDHVIDATLTGGPARYINHSCAPNCVAEVVTFERGHKIIISSSRRIQ 4949
            ||||||||||||||||:||:|||||||||||||||||||||||||||||||:||:|||||:||||
Frog  5005 KEKLYESQNRGVYMFRIDNEHVIDATLTGGPARYINHSCAPNCVAEVVTFEKGHRIIISSNRRIQ 5069

Human  4950 KGEELCYDYKFDFEDDQHKIPCHCGAVNCRKWMN 4983
            |||||.||||||||||||||||||||||||||||
Frog  5070 KGEELSYDYKFDFEDDQHKIPCHCGAVNCRKWMN 5103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KMT2C	XP_005250082.1	ePHD1_KMT2C	248..331	CDD:277166	63/82 (77%)
		PHD1_KMT2C_like	344..389	CDD:276984	41/44 (93%)
		PHD2_KMT2C	391..436	CDD:277069	39/44 (89%)
		PHD3_KMT2C	467..518	CDD:276986	31/51 (61%)
		PHD4_KMT2C	953..1009	CDD:277071	53/55 (96%)
		PHD5_KMT2C_like	1010..1056	CDD:276988	44/45 (98%)
		RanBP2-type Zn finger	1085..1107	CDD:275375	16/21 (76%)
		PHD6_KMT2C	1087..1137	CDD:277073	36/49 (73%)
		HMG-box	1671..1722	CDD:294061	47/50 (94%)
		DUF2962	1709..>1792	CDD:288077	72/82 (88%)
		SYCE1	<3198..3287	CDD:291886	79/88 (90%)
		ePHD2_KMT2C	4474..4578	CDD:277167	98/103 (95%)
		FYRN	4624..4674	CDD:283589	43/49 (88%)
		FYRC	4680..4761	CDD:283590	60/80 (75%)
		SET	<4797..4983	CDD:225491	179/185 (97%)
		SET	4844..4965	CDD:214614	114/120 (95%)
		PostSET	4967..4983	CDD:214703	15/15 (100%)
kmt2c	XP_031760372.1	PHD_SF	244..327	CDD:419867	63/82 (77%)
		PHD1_KMT2C_like	340..385	CDD:276984	41/44 (93%)
		PHD2_KMT2C	387..432	CDD:277069	39/44 (89%)
		PHD3_KMT2C	464..515	CDD:276986	30/50 (60%)
		PHD4_KMT2C	919..975	CDD:277071	53/55 (96%)
		PHD5_KMT2C_like	976..1022	CDD:276988	44/45 (98%)
		PHD_SF	1053..1103	CDD:419867	36/49 (73%)
		HMG	1645..1698	CDD:197700	49/52 (94%)
		PHA03247	<2019..2550	CDD:223021	184/542 (34%)
		Myosin_tail_1	<3363..>3450	CDD:396244	78/86 (91%)
		PHD_SF	4594..4698	CDD:419867	98/103 (95%)
		FYRN	4743..4794	CDD:399155	44/50 (88%)
		FYRC	4801..4884	CDD:399156	63/82 (77%)
		SET_KMT2C_2D	4950..5102	CDD:380948	145/151 (96%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	2242	1.000	Domainoid score	I67
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H46480
Inparanoid	1	1.050	3176	1.000	Inparanoid score	I219
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39671at33208
OrthoFinder	1	1.000	-	-		FOG0002860
OrthoInspector	1	1.000	-	-		oto152034
Panther	1	1.100	-	-	LDO	PTHR45888
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160