DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARHGAP22 and si:dkey-191m6.4

DIOPT Version :9

Sequence 1:	XP_011538304.1	Gene:	ARHGAP22 / 58504	HGNCID:	30320	Length:	720	Species:	Homo sapiens
Sequence 2:	XP_683216.5	Gene:	si:dkey-191m6.4 / 555573	ZFINID:	ZDB-GENE-121214-182	Length:	696	Species:	Danio rerio

Alignment Length:	716	Identity:	396/716 - (55%)
Similarity:	489/716 - (68%)	Gaps:	59/716 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    19 RSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKP 83
            ||||:||||.||...|...|.....||||||||||||||||||.||||||.|.||:|||::|.||
Zfish    16 RSKSMVMGEASRGSCRPTSPSLQEGVLKAGWLKKQRSIMKNWQLRWFVLRADHLFFYKDEEETKP 80

Human    84 QGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRR 148
            ||.|||:|:||.||...||:||:|||||.|  |||::|...:.|:.||||::|.||:|||:||||
Zfish    81 QGCISLKGSQVNELTANPEEPGRHLFEILP--AGEKDKAAMSHESFLLMANTQSDMDDWVKAIRR 143

Human   149 VIWAPLGGGTARRSHAHPLEPLPPGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGLTEE 213
            |||||.||                ||||||||:||.:|||:||||||||||||||||||:||.||
Zfish   144 VIWAPFGG----------------GIFGQRLEDTVQYERKFGPRLAPLLVEQCVDFIREQGLDEE 192

Human   214 GLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYEDFLSCAQ 278
            ||||||||||||::||::||||:||.|||.||||||||||||||||||||||||.:|||||:|||
Zfish   193 GLFRMPGQANLVKELQEAFDCGDKPQFDSNTDVHTVASLLKLYLRELPEPVVPFCKYEDFLTCAQ 257

Human   279 LLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLATVFGPNILRPQV 343
            ||||||.||..||.|.|..||.||:|||:||||||||||::|:.|||.|||||||||||:|||::
Zfish   258 LLTKDEEEGIQELGKLVMTLPAANFNLLKYICKFLDEVQSHSHENKMGVQNLATVFGPNMLRPKM 322

Human   344 EDPVTIMEGTSLVQHLMTVLIRKHSQLFT---APVPEGPTSPRGGLQ----CAVGWGSEEVTRDS 401
            ||||.||||||||||||||||.:|.:|:|   :...:..|..:...|    ..|.|.||| ..::
Zfish   323 EDPVAIMEGTSLVQHLMTVLISEHDRLYTEKDSEASQTQTEDQNQQQNQPSTLVDWISEE-DLNT 386

Human   402 QGEPGGPGLPAHRT-SSLDGAAVAVLSRTAPTGPG-SRCSPGKKVQTLPSWKSSFRQ---PRSLS 461
            .|.|.....|:..: ||:||.:.   |:|.|.|.| :..||.|:.:|||.||.:|.:   ||..|
Zfish   387 TGPPTAKNDPSSSSASSVDGVST---SKTMPQGKGETAVSPSKQPKTLPGWKYTFNKGSSPRPQS 448

Human   462 GSPKGGGSSLEVPIISSGGNWLMNGLSSLRGHRRASSGDRLKDSGSVQRLSTYDNVPAPGLVPGI 526
            .  |..||:::|   ||.||||||||||||||||.|||:|.:||||.|||||||||.:...:..:
Zfish   449 A--KVSGSAVDV---SSSGNWLMNGLSSLRGHRRTSSGERSRDSGSSQRLSTYDNVTSSSSLGSV 508

Human   527 PSVASMAWSGASSSESSVGGSLSSCTACRASDSSARSSLHTDWALEPSPLPSSSEDPKSLDL--- 588
            .|:.|..|| :||.|.||..|.|..........:           |||.|...:.|.::...
Zfish   509 LSMDSTPWS-SSSCEISVPDSGSDPLGTEDGPQT-----------EPSVLEERTTDDETKSTGQE 561

Human   589 DHSMDEAGAGASNSEPSEPDSP----TREHARRS-EALQGLVTELRAELCRQRTEYERSVKRIEE 648
            |.|.:...:|...|:.....:|    ..|.|..| .:|..:|.||:.||..|:..||..:|::||
Zfish   562 DSSAEHRASGLFRSDNGNAAAPLIRVVDEDADESTSSLVNVVAELKEELRAQKQTYESRIKKLEE 626

Human   649 GSADLRKRMSRLEEELDQEKKKYIMLEIKLRNSERAREDAERRNQLLQREMEEFFSTLGSLTVGA 713
            .:..|...|.|||:|::|::|:..|||||||||||||||||.||:||::|||:||:|||.|.:|:
Zfish   627 SNTALCAHMERLEQEMEQDRKRKRMLEIKLRNSERAREDAENRNRLLEKEMEDFFATLGDLALGS 691

Human   714 K 714
            :
Zfish   692 R 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARHGAP22	XP_011538304.1	PH_RhoGAP2	42..157	CDD:241529	78/114 (68%)
		RhoGAP_ARHGAP22_24_25	173..371	CDD:239855	158/197 (80%)
		SMC_N	<612..>700	CDD:330553	45/88 (51%)
si:dkey-191m6.4	XP_683216.5	PH-like	39..152	CDD:302622	79/130 (61%)
		PH	41..145	CDD:278594	72/105 (69%)
		RhoGAP_ARHGAP22_24_25	152..350	CDD:239855	158/197 (80%)
		GBP_C	<601..680	CDD:303769	43/78 (55%)
		coiled coil	651..662	CDD:293879	10/10 (100%)
		coiled coil	670..680	CDD:293879	6/9 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194326161
Domainoid	1	1.000	275	1.000	Domainoid score	I8435
eggNOG	1	0.900	-	-		E1_KOG4270
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	727	1.000	Inparanoid score	I4036
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG39673
OrthoDB	1	1.010	-	-		D176935at7742
OrthoFinder	1	1.000	-	-		FOG0001050
OrthoInspector	1	1.000	-	-		oto50740
orthoMCL	1	0.900	-	-		OOG6_106449
Panther	1	1.100	-	-	LDO	PTHR15228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8557
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770