DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment BBS4 and Utx

DIOPT Version :9

Sequence 1:NP_149017.2 Gene:BBS4 / 585 HGNCID:969 Length:519 Species:Homo sapiens
Sequence 2:NP_609368.3 Gene:Utx / 34377 FlyBaseID:FBgn0260749 Length:1136 Species:Drosophila melanogaster


Alignment Length:526 Identity:110/526 - (20%)
Similarity:196/526 - (37%) Gaps:124/526 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    72 VQALIFRLE-----GNIQESLELFQTCAVLSPQSADNLKQVAR--SLFLLGKHKAAIEVYNEAAK 129
            ||..|..|:     |.:.|           |..|:||...:.:  .....|:|     :.|.:::
  Fly    37 VQQTITNLQNYIANGQVHE-----------SKNSSDNKNAIQKFEPSTQAGEH-----MENTSSR 85

Human   130 LNQ--KDWEISHNLGVCYIYLKQFNKAQDQLH-NALNLNRHDLTYIMLGKIHLLEGDLDKAIEVY 191
            .|.  |.:|......|..|.    .|.||:.: |||         ..||.:|||.|:..:|:..|
  Fly    86 NNDDTKPFEQDAKEKVSIIE----EKHQDEHYVNAL---------CKLGHLHLLLGEYSEALSAY 137

Human   192 KKAVEFSPE----NTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNY----KAILAAGSMMQT 248
            :|.:.|...    |...:..:|:.|.:|..::.|.:.....|...| |:    :..|..|.|::.
  Fly   138 QKYLRFRENNYWTNHAFIYGIGVAYFKLRCFKWAIKSFQELLYLSP-NFTCANEVHLRLGLMLKH 201

Human   249 HGDFDVALTKYRVVACAVPESPPLWN------NIGMCFFGKKKYVAA------------ISCLKR 295
            .|:|.:||...::  ..:...|..::      .|...:..:.|:.||            ||...:
  Fly   202 CGEFHIALKHLQL--ALLYTYPSTFSELQVKFQIAHLYEVQNKHKAAKDGYEFLLNEKNISLELK 264

Human   296 ANYLAPFDWKILYN----LGLVHLTMQQYASAFHFLSAAINFQPKMGE-LYML------------ 343
            |:......|  :|:    ||   ...::.|:|.:||..:|...||.|: ||:|            
  Fly   265 ADVYRQLGW--MYHCVECLG---EKKEREANALNFLQKSIEADPKSGQSLYLLGRCYAGINKVHD 324

Human   344 ---------------------LAVALTNLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGE 387
                                 :.|.........:|.:||..||.|||.:.....|..:|..:.|:
  Fly   325 AFLAYRNSVEKSEGNADTWCSIGVLYQQQNQPTDALQAYICAVQLDKDHKAAWTNLGILYESCGQ 389

Human   388 KKNALAQYQEMEKKV-----SLLKDNSSLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKSKH 447
            .::|.|.|....|::     ||::...::....:.:.:::.|...:...|..:...|:....||.
  Fly   390 LRDAYACYLNATKQISFQKSSLIRKKQAIRMKKDTIGLSKGLSQRITFLEGQLSQAPLPSITSKR 454

Human   448 QTTSTSKPASFQQPLGSNQALGQAMSSAAAYRTLPSGAGGTSQFTKPPSLPLEPEPAVESSPTET 512
            :...:.:.| :..|:.......|..::    :.||......|....||  |..|...:..||. .
  Fly   455 RQLCSIEEA-WNLPISLEMNSRQQQTA----QMLPRQVTKQSPVQGPP--PPYPHSQLSQSPI-P 511

Human   513 SEQIRE 518
            |::|:|
  Fly   512 SKRIKE 517

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BBS4NP_149017.2 Required for localization to centrosomes 1..66
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
TPR_11 <18..400 CDD:330823 87/401 (22%)
TPR repeat 36..61 CDD:276809
TPR 1 67..100 7/32 (22%)
TPR repeat 68..95 CDD:276809 6/27 (22%)
Interaction with PCM1. /evidence=ECO:0000269|PubMed:15107855 101..337 59/270 (22%)
TPR repeat 101..129 CDD:276809 5/29 (17%)
TPR repeat 134..164 CDD:276809 9/30 (30%)
TPR repeat 169..196 CDD:276809 9/26 (35%)
TPR repeat 202..229 CDD:276809 4/26 (15%)
TPR repeat 236..264 CDD:276809 7/31 (23%)
TPR repeat 270..298 CDD:276809 8/45 (18%)
TPR repeat 303..333 CDD:276809 9/33 (27%)
Required for localization to centrosomes 338..519 42/220 (19%)
TPR repeat 338..365 CDD:276809 8/60 (13%)
TPR repeat 372..397 CDD:276809 6/24 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..519 17/79 (22%)
UtxNP_609368.3 TPR repeat 147..181 CDD:276809 6/33 (18%)
TPR_11 156..216 CDD:290150 14/62 (23%)
TPR repeat 186..216 CDD:276809 7/31 (23%)
TPR repeat 228..255 CDD:276809 4/26 (15%)
TPR_11 264..337 CDD:290150 16/77 (21%)
TPR repeat 265..300 CDD:276809 9/39 (23%)
TPR repeat 307..334 CDD:276809 3/26 (12%)
TPR_11 339..402 CDD:290150 15/62 (24%)
TPR repeat 339..369 CDD:276809 6/29 (21%)
TPR_1 340..373 CDD:278916 9/32 (28%)
TPR repeat 374..402 CDD:276809 6/27 (22%)
JmjC 870..978 CDD:202224
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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